Toll-like receptor signaling pathway (Danio rerio)

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Description

Toll-like receptors (TLRs) are a critical part of the innate immune response, and are expressed on macrophages and dendritic cells. TLRs are pattern-recognition receptors, and recognize molecules derived from microbes. Once activated, TLRs result in activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP75(r30264) with a 56% conversion rate.

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
142130view07:35, 4 December 2025EgonwModified description
118905view21:50, 3 June 2021EweitzOntology Term : 'signaling pathway pertinent to development' added !
118904view21:50, 3 June 2021EweitzOntology Term : 'Toll-like receptor signaling pathway' added !
87796view11:16, 25 July 2016MirellaKalafatiOntology Term : 'signaling pathway' added !
77485view11:40, 16 September 2014VenemanEnsembl annotation updated
77484view11:30, 16 September 2014VenemanSpecify description
77483view09:58, 16 September 2014Venemantnfa and tnfb added
77479view14:51, 15 September 2014VenemanLepb added
68667view05:25, 6 July 2013MaintBotUpdated to 2013 gpml schema
40839view22:18, 1 March 2011MaintBotRemoved redundant pathway information and comments
34222view21:35, 9 December 2009MaintBotAutomatic update of empty xrefs
32343view13:35, 15 August 2009MaintBotFixed text labels
31959view13:04, 14 August 2009MaintBotFixed group labels
31390view20:45, 13 August 2009MaintBotFixed text labels
31096view01:39, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CCL3GeneProductOriginal kegg element: gene;44;hsa:6348
CCL4GeneProductOriginal kegg element: gene;38;hsa:6351
CCL5GeneProductOriginal kegg element: gene;58;hsa:6352
CD14GeneProductOriginal kegg element: gene;84;hsa:929
CD40GeneProductENSDARG00000054968 (Ensembl) Original kegg element: gene;29;hsa:958
CD80GeneProductOriginal kegg element: gene;69;hsa:941
CD86GeneProductOriginal kegg element: gene;28;hsa:942
CXCL10GeneProductOriginal kegg element: gene;25;hsa:3627
CXCL11GeneProductOriginal kegg element: gene;23;hsa:6373
CXCL9GeneProductOriginal kegg element: gene;24;hsa:4283
IFNA1GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA10GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA13GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA14GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA16GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA17GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA2GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA21GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA4GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA5GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA6GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA7GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNA8GeneProductOriginal kegg element: gene;27;hsa:3439 hsa:3440 hsa:3441 hsa:3442 hsa:3443 hsa:3444 hsa:3445 hsa:3446 hsa:3447 hsa:3448 hsa:3449 hsa:3451 hsa:3452
IFNAR1GeneProductOriginal kegg element: gene;49;hsa:3454 hsa:3455
IFNAR2GeneProductOriginal kegg element: gene;49;hsa:3454 hsa:3455
IFNB1GeneProductOriginal kegg element: gene;1;hsa:3456
IKBKEGeneProduct437024 (Entrez Gene) Original kegg element: gene;54;hsa:9641
IL12AGeneProduct445410 (Entrez Gene) Original kegg element: gene;45;hsa:3592 hsa:3593
IL12BGeneProductOriginal kegg element: gene;45;hsa:3592 hsa:3593
IL1BGeneProduct405770 (Entrez Gene) Original kegg element: gene;51;hsa:3553
IL6GeneProductOriginal kegg element: gene;57;hsa:3569
IL8GeneProductOriginal kegg element: gene;43;hsa:3576
IRF5GeneProduct405811 (Entrez Gene) Original kegg element: gene;21;hsa:3663
LBPGeneProductOriginal kegg element: gene;77;hsa:3929
LOC100004036GeneProduct100004036 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
LOC100149273GeneProduct100149273 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
LOC557176GeneProduct557176 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
LOC560549GeneProduct560549 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
LOC560913GeneProduct560913 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
LOC561737GeneProduct561737 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
LOC563727GeneProduct563727 (Entrez Gene) Original kegg element: gene;13;hsa:1326
LOC792354GeneProduct792354 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
LY96GeneProductOriginal kegg element: gene;71;hsa:23643
LepbGeneProductENSDARG00000045548 (Ensembl) Original kegg element: gene;57;hsa:3569
MAP2K3GeneProductOriginal kegg element: gene;65;hsa:5606 hsa:5608
MAP3K7IP2GeneProduct494163 (Entrez Gene) Original kegg element: gene;61;hsa:23118
MAPK12GeneProduct30681 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
NFKB1GeneProduct565756 (Entrez Gene) Original kegg element: gene;14;hsa:4790
NFKBIAGeneProductOriginal kegg element: gene;64;hsa:4792
SPP1GeneProductENSDARG00000044276 (Ensembl) Original kegg element: gene;15;hsa:6696
TICAM2GeneProductOriginal kegg element: gene;80;hsa:353376
TLR1GeneProduct403127 (Entrez Gene) Original kegg element: gene;75;hsa:7096
TLR3GeneProduct403126 (Entrez Gene) Original kegg element: gene;73;hsa:7098
TLR4GeneProductOriginal kegg element: gene;79;hsa:7099
TLR5aGeneProductENSDARG00000044415 (Ensembl) Original kegg element: gene;72;hsa:7100
TLR5bGeneProductENSDARG00000052322 (Ensembl) Original kegg element: gene;72;hsa:7100
TNFGeneProductOriginal kegg element: gene;66;hsa:7124
akt2GeneProduct378972 (Entrez Gene) Original kegg element: gene;60;hsa:10000 hsa:207 hsa:208
casp8GeneProduct58022 (Entrez Gene) Original kegg element: gene;87;hsa:841
chukGeneProduct393287 (Entrez Gene) Original kegg element: gene;42;hsa:1147
faddGeneProduct562317 (Entrez Gene) Original kegg element: gene;56;hsa:8772
fosGeneProduct394198 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
ikbkbGeneProduct563560 (Entrez Gene) Original kegg element: gene;36;hsa:3551
ikbkgGeneProduct541530 (Entrez Gene) Original kegg element: gene;85;hsa:8517
im:7136778GeneProduct100002318 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
irak1GeneProduct569226 (Entrez Gene) Original kegg element: gene;41;hsa:3654
irak4GeneProduct393132 (Entrez Gene) Original kegg element: gene;86;hsa:51135
irf3GeneProduct564854 (Entrez Gene) Original kegg element: gene;67;hsa:3661
irf7GeneProduct393650 (Entrez Gene) Original kegg element: gene;20;hsa:3665
junGeneProduct335916 (Entrez Gene) Original kegg element: gene;35;hsa:2353 hsa:3725
map2k1GeneProduct406728 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
map2k6GeneProduct65239 (Entrez Gene) Original kegg element: gene;65;hsa:5606 hsa:5608
map3k7GeneProduct553788 (Entrez Gene) Original kegg element: gene;37;hsa:6885
map3k7ip1GeneProduct403084 (Entrez Gene) Original kegg element: gene;59;hsa:10454
mapk10GeneProduct569698 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
mapk1GeneProduct360144 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
mapk14aGeneProduct65237 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300
mapk3GeneProduct399480 (Entrez Gene) Original kegg element: gene;11;hsa:5594 hsa:5595
myd88GeneProduct403145 (Entrez Gene) Original kegg element: gene;47;hsa:4615
nfkb2GeneProduct415100 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
pik3cdGeneProduct394174 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
pik3r2GeneProduct404211 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
pik3r3GeneProduct100000252 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
rac1GeneProduct327204 (Entrez Gene) Original kegg element: gene;48;hsa:5879
relaGeneProduct415099 (Entrez Gene) Original kegg element: gene;10;hsa:4790 hsa:4791 hsa:5970
ripk1lGeneProduct567460 (Entrez Gene) Original kegg element: gene;17;hsa:8737
stat1aGeneProduct30768 (Entrez Gene) Original kegg element: gene;62;hsa:6772
tbk1GeneProduct692289 (Entrez Gene) Original kegg element: gene;52;hsa:29110
ticam1GeneProduct403147 (Entrez Gene) Original kegg element: gene;82;hsa:148022
tirapGeneProduct403148 (Entrez Gene) Original kegg element: gene;83;hsa:114609
tlr1GeneProduct403127 (Entrez Gene) Original kegg element: gene;76;hsa:10333
tlr2GeneProduct403125 (Entrez Gene) Original kegg element: gene;74;hsa:7097
tlr7GeneProduct403129 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
tlr8aGeneProduct403137 (Entrez Gene) Original kegg element: gene;39;hsa:51284 hsa:51311
tlr9GeneProduct403128 (Entrez Gene) Original kegg element: gene;78;hsa:54106
tnfaGeneProductENSDARG00000009511 (Ensembl)
tnfbGeneProductENSDARG00000013598 (Ensembl)
tollipGeneProduct336876 (Entrez Gene) Original kegg element: gene;81;hsa:54472
traf3GeneProduct445119 (Entrez Gene) Original kegg element: gene;16;hsa:7187
traf6GeneProduct554561 (Entrez Gene) Original kegg element: gene;53;hsa:7189
wu:fb92a07GeneProduct100002263 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
zgc:172209GeneProduct562720 (Entrez Gene) Original kegg element: gene;50;hsa:5599 hsa:5601 hsa:5602
zgc:172250GeneProduct100002225 (Entrez Gene) Original kegg element: gene;12;hsa:5604 hsa:5605
zgc:194486GeneProduct568951 (Entrez Gene) Original kegg element: gene;63;hsa:5609 hsa:6416
zgc:77033GeneProduct406598 (Entrez Gene) Original kegg element: gene;55;hsa:23533 hsa:5290 hsa:5291 hsa:5293 hsa:5294 hsa:5295 hsa:5296 hsa:8503
zgc:86905GeneProduct415185 (Entrez Gene) Original kegg element: gene;40;hsa:1432 hsa:5600 hsa:5603 hsa:6300

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1384"
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