Bone morphogenic protein signaling and regulation (Homo sapiens)
From WikiPathways
Description
"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into the nucleus where they interact with other transcription factors, such as Runx2 in osteoblasts." (Chen 2004).
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
- Chen D, Zhao M, Mundy GR; ''Bone morphogenetic proteins.''; Growth Factors, 2004 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
BMP2 | GeneProduct | ENSG00000125845 (Ensembl) | |
BMPR1A | GeneProduct | ENSG00000107779 (Ensembl) | |
BMPR1B | GeneProduct | ENSG00000138696 (Ensembl) | |
BMPR2 | GeneProduct | 659 (Entrez Gene) | |
NOG | GeneProduct | ENSG00000183691 (Ensembl) | |
RUNX2 | GeneProduct | ENSG00000124813 (Ensembl) | |
SMAD1 | GeneProduct | ENSG00000170365 (Ensembl) | |
SMAD4 | GeneProduct | ENSG00000141646 (Ensembl) | |
SMAD6 | GeneProduct | ENSG00000137834 (Ensembl) | |
SMURF1 | GeneProduct | ENSG00000198742 (Ensembl) | |
TOB1 | GeneProduct | ENSG00000141232 (Ensembl) | |
TOB2 | GeneProduct | ENSG00000183864 (Ensembl) |
Annotated Interactions
No annotated interactions