Bone morphogenic protein signaling and regulation (Homo sapiens)

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Andra Waagmeester, Kristina Hanspers, Alexander Pico, Babiker Malik Osman, et al.

Description

"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into the nucleus where they interact with other transcription factors, such as Runx2 in osteoblasts." [Chen 2004](http://www.ncbi.nlm.nih.gov/pubmed/15621726 ). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP1425).

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Ontology Terms

Pathway Ontology : drug pathway altered cholesterol transport pathway altered cholesterol biosynthetic pathway

Cell Type : hepatocyte

Bibliography

Chen D, Zhao M, Mundy GR; ''Bone morphogenetic proteins.''; Growth Factors, 2004 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
137534	view	19:09, 3 March 2025	Khanspers	Modified description
126273	view	16:23, 19 April 2023	Egonw	License is CCZero
123619	view	08:20, 7 August 2022	Egonw	Modified title
116437	view	09:42, 7 May 2021	Eweitz	Modified title
106344	view	21:33, 21 August 2019	Khanspers	Modified description
105545	view	06:09, 9 August 2019	Khanspers	Modified description
86082	view	11:26, 29 June 2016	MirellaKalafati	Modified title
74390	view	22:37, 15 April 2014	Khanspers	Changed OSE2 binding site rectangle to label
73562	view	19:52, 1 February 2014	AlexanderPico	Correcting designation of BMPR1B as a GeneProduct rather than a Pathway data node
69901	view	19:29, 11 July 2013	AlexanderPico	Modified title
68904	view	17:30, 8 July 2013	MaintBot	Updated to 2013 gpml schema
59105	view	22:20, 21 February 2013	MaintBot	Updated Ensembl and UniProt data source
44981	view	14:27, 6 October 2011	MartijnVanIersel	Ontology Term : 'BMP signaling pathway ' added !
42559	view	18:50, 4 April 2011	Babikerosman	Periodical save, work in progress
42558	view	18:40, 4 April 2011	Babikerosman	Periodical save, work in progress
41051	view	23:16, 1 March 2011	MaintBot	Removed redundant pathway information and comments
39169	view	17:28, 26 October 2010	Vfunari	Periodical save, work in progress
38973	view	18:02, 25 September 2010	AlexanderPico	Modified description
38972	view	18:00, 25 September 2010	AlexanderPico	overhaul
38955	view	00:33, 25 September 2010	Khanspers
38954	view	00:32, 25 September 2010	Khanspers	Added nucleus, changed line types
33373	view	14:35, 30 November 2009	MaintBot	Removed group label
33180	view	17:42, 5 November 2009	Khanspers	Modified categories
33113	view	12:21, 19 October 2009	Andra	New pathway

External references

DataNodes

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Name	Type	Database reference
BMP2	GeneProduct	ENSG00000125845 (Ensembl)
BMPR1A	GeneProduct	ENSG00000107779 (Ensembl)
BMPR1B	GeneProduct	ENSG00000138696 (Ensembl)
BMPR2	GeneProduct	659 (Entrez Gene)
NOG	GeneProduct	ENSG00000183691 (Ensembl)
RUNX2	GeneProduct	ENSG00000124813 (Ensembl)
SMAD1	GeneProduct	ENSG00000170365 (Ensembl)
SMAD4	GeneProduct	ENSG00000141646 (Ensembl)
SMAD6	GeneProduct	ENSG00000137834 (Ensembl)
SMURF1	GeneProduct	ENSG00000198742 (Ensembl)
TOB1	GeneProduct	ENSG00000141232 (Ensembl)
TOB2	GeneProduct	ENSG00000183864 (Ensembl)