Bone morphogenic protein signaling and regulation (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none CytoplasmNucleusTarget genesOSE2 binding sitesBMP2BMPR2SMAD1SMURF1SMURF1NOGSMURF1SMAD6SMURF1SMAD6SMAD1SMAD1SMAD4TOB1TOB2BMPR1ABMPR1BSMAD1SMAD1RUNX2Name: Bone morphogenic protein signaling and regulationLast Modified: 2/21/2013Organism: Homo sapiens


Description

"BMP signals are mediated by type I and II BMP receptors and their downstream molecules Smad1, 5 and 8. Phosphorylated Smad1, 5 and 8 proteins form a complex with Smad4 and then are translocated into the nucleus where they interact with other transcription factors, such as Runx2 in osteoblasts." [Chen 2004](http://www.ncbi.nlm.nih.gov/pubmed/15621726 ). Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP1425).

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Quality Tags

Image:Featured.pngReview changes for Featured
Image:Curated.pngApproved version

Ontology Terms

Pathway Ontology : BMP signaling pathway
 

Bibliography

  1. Chen D, Zhao M, Mundy GR; ''Bone morphogenetic proteins.''; Growth Factors, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137534
Approved
view19:09, 3 March 2025KhanspersModified description
126273
Featured
view16:23, 19 April 2023EgonwLicense is CCZero
123619view08:20, 7 August 2022EgonwModified title
116437view09:42, 7 May 2021EweitzModified title
106344view21:33, 21 August 2019KhanspersModified description
105545view06:09, 9 August 2019KhanspersModified description
86082view11:26, 29 June 2016MirellaKalafatiModified title
74390view22:37, 15 April 2014KhanspersChanged OSE2 binding site rectangle to label
73562view19:52, 1 February 2014AlexanderPicoCorrecting designation of BMPR1B as a GeneProduct rather than a Pathway data node
69901view19:29, 11 July 2013AlexanderPicoModified title
68904view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
59105view22:20, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
44981view14:27, 6 October 2011MartijnVanIerselOntology Term : 'BMP signaling pathway ' added !
42559view18:50, 4 April 2011BabikerosmanPeriodical save, work in progress
42558view18:40, 4 April 2011BabikerosmanPeriodical save, work in progress
41051view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
39169view17:28, 26 October 2010VfunariPeriodical save, work in progress
38973view18:02, 25 September 2010AlexanderPicoModified description
38972view18:00, 25 September 2010AlexanderPicooverhaul
38955view00:33, 25 September 2010Khanspers
38954view00:32, 25 September 2010KhanspersAdded nucleus, changed line types
33373view14:35, 30 November 2009MaintBotRemoved group label
33180view17:42, 5 November 2009KhanspersModified categories
33113view12:21, 19 October 2009AndraNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BMP2GeneProductENSG00000125845 (Ensembl)
BMPR1AGeneProductENSG00000107779 (Ensembl)
BMPR1BGeneProductENSG00000138696 (Ensembl)
BMPR2GeneProduct659 (Entrez Gene)
NOGGeneProductENSG00000183691 (Ensembl)
RUNX2GeneProductENSG00000124813 (Ensembl)
SMAD1GeneProductENSG00000170365 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SMAD6GeneProductENSG00000137834 (Ensembl)
SMURF1GeneProductENSG00000198742 (Ensembl)
TOB1GeneProductENSG00000141232 (Ensembl)
TOB2GeneProductENSG00000183864 (Ensembl)

Annotated Interactions

No annotated interactions

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