Target of rapamycin signaling (Homo sapiens)

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1-3, 54Hypoxiahigh AMP:ATPmTORC1Amino acidsmTORC2SurvivalAMPKAKT1S1PRKAB2RRAGBULK1IDI1PRKAA1ULK2RICTORMLST8PRKAG3MAPKAP1TSC2ULK3Actin OrganizationPRR5FKBP1APRKAG2DDIT4LHMGCRAutophagymRNA translationPRKCAInsulin signalingAKT1TSC1MLST8RRAGDMTORRapamycinEIF4EBP1PRKAG1PRKAA2PRKAB1CDC42MyelinationRibosome biogenesisSREPB2RPS6KB1RRAGCCytoskeletal dynamicsRRAGARPTORDDIT4MTORRHEBInsulin signalingPRR5LRAC16666Amino acids


Description

TOR signaling is responsible for a cellular reaction towards nutrient and energy availability and hypoxia/stress. The mammalian Target Of Rapamycin (mTOR), a serine/threonine kinase, is the central regulator that consists in two different complexes: a rapamycin-sensitive complex (mTORC1) consisting of mTOR, Raptor and GbetaL that regulates mRNA translation, ribosome biogenesis and autophagy and a second rapamycin-insensitive complex (mTORC2) consisting of mTOR, Rictor GbetaL, Sin1 and Protor 1/2 that regulates survival and a cytoskeletal response.

TOR signaling is highly integrated in other signaling pathways that respond to external conditions, such as the insulin-signaling cascade and AMPK signaling.

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Bibliography

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  1. Inoki K, Guan KL; ''Complexity of the TOR signaling network.''; Trends Cell Biol, 2006 PubMed Europe PMC Scholia
  2. Yang Q, Guan KL; ''Expanding mTOR signaling.''; Cell Res, 2007 PubMed Europe PMC Scholia
  3. Corradetti MN, Guan KL; ''Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?''; Oncogene, 2006 PubMed Europe PMC Scholia
  4. Sancak Y, Sabatini DM; ''Rag proteins regulate amino-acid-induced mTORC1 signalling.''; Biochem Soc Trans, 2009 PubMed Europe PMC Scholia
  5. Wullschleger S, Loewith R, Hall MN; ''TOR signaling in growth and metabolism.''; Cell, 2006 PubMed Europe PMC Scholia
  6. Norrmén C, Figlia G, Lebrun-Julien F, Pereira JA, Trötzmüller M, Köfeler HC, Rantanen V, Wessig C, van Deijk AL, Smit AB, Verheijen MH, Rüegg MA, Hall MN, Suter U; ''mTORC1 controls PNS myelination along the mTORC1-RXRγ-SREBP-lipid biosynthesis axis in Schwann cells.''; Cell Rep, 2014 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
126354view09:35, 23 April 2023EgonwLicense is CCZero
123616view08:20, 7 August 2022EgonwModified title
120934view09:06, 1 February 2022EgonwMade three pathways clickable
116793view10:00, 14 May 2021EweitzModified title
106444view23:34, 28 August 2019KhanspersModified description
105496view05:50, 8 August 2019KhanspersModified description
94755view15:33, 5 October 2017Mkutmonfix unconnected line
90258view20:01, 27 October 2016AlexanderPicoupdated compartment and graphical object types
86079view10:06, 29 June 2016MirellaKalafatiModified title
82750view03:25, 27 October 2015Jlw9added components of myelination pathway
82749view03:15, 27 October 2015Jlw9Periodical save, work in progress
82748view02:55, 27 October 2015Jlw9Periodical save, work in progress
82747view02:45, 27 October 2015Jlw9Periodical save, work in progress
82219view02:39, 16 September 2015AlexanderPicoclarified interactions for biopax conversion
70031view01:57, 12 July 2013AlexanderPicoModified title
69007view17:46, 8 July 2013MaintBotUpdated to 2013 gpml schema
61698view23:24, 16 April 2013MaintBotremoved data source without identifer
60230view20:12, 14 March 2013EgonwReplaced PubChem-substance with PubChem-compound.
60227view20:10, 14 March 2013EgonwAnnotated 'amino acid' with an ChEBI entry.
59195view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
48241view06:07, 17 May 2012MaintBotUpdating PubChem xrefs
45081view20:42, 6 October 2011KhanspersOntology Term : 'insulin signaling pathway' added !
45080view20:41, 6 October 2011KhanspersOntology Term : 'AMPK signaling pathway' added !
45078view20:40, 6 October 2011KhanspersOntology Term : 'mTOR signaling pathway' added !
41181view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38698view19:08, 23 September 2010AlexanderPicopathway nodes
38691view18:26, 23 September 2010AlexanderPicoadded pathway nodes; altered labels for conditions and phenotypes
36157view16:59, 3 March 2010Pieter GiesbertzSpecify description
36156view15:53, 3 March 2010Pieter GiesbertzModified categories
36155view15:48, 3 March 2010Pieter GiesbertzSpecify description
36140view12:31, 3 March 2010Pieter GiesbertzSpecify description
36139view12:15, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36138view11:44, 3 March 2010Pieter GiesbertzModified description
36137view11:41, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36095view10:09, 3 March 2010Pieter GiesbertzAdded literature
36042view09:17, 3 March 2010Pieter GiesbertzSpecify description
36041view09:06, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36040view08:35, 3 March 2010Pieter GiesbertzPeriodical save, work in progress
36039view16:22, 2 March 2010Pieter GiesbertzSpecify description
36038view16:19, 2 March 2010Pieter GiesbertzSpecify description
36037view16:17, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36035view16:06, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36032view15:40, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36031view15:17, 2 March 2010Pieter GiesbertzSpecify description
36030view15:10, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36029view15:00, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36026view12:55, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36025view12:39, 2 March 2010Pieter GiesbertzSpecify description
36024view12:34, 2 March 2010Pieter GiesbertzPeriodical save, work in progress
36023view12:14, 2 March 2010Pieter GiesbertzPeriodical save, work in progress

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
Actin OrganizationPathway
AutophagyPathway
CDC42GeneProductENSG00000070831 (Ensembl)
Cytoskeletal dynamicsPathway
DDIT4GeneProductENSG00000168209 (Ensembl)
DDIT4LGeneProductENSG00000145358 (Ensembl)
EIF4EBP1GeneProductENSG00000187840 (Ensembl)
FKBP1AGeneProductENSG00000088832 (Ensembl)
HMGCRGeneProduct3156 (Entrez Gene)
IDI1GeneProductENSG00000067064 (Ensembl)
Insulin signalingPathwayWP481 (WikiPathways)
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
MyelinationPathway
PRKAA1GeneProductENSG00000132356 (Ensembl)
PRKAA2GeneProductENSG00000162409 (Ensembl)
PRKAB1GeneProductENSG00000111725 (Ensembl)
PRKAB2GeneProductENSG00000131791 (Ensembl)
PRKAG1GeneProductENSG00000181929 (Ensembl)
PRKAG2GeneProductENSG00000106617 (Ensembl)
PRKAG3GeneProductENSG00000115592 (Ensembl)
PRKCAGeneProductENSG00000154229 (Ensembl)
PRR5GeneProductENSG00000186654 (Ensembl)
PRR5LGeneProductENSG00000135362 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RHEBGeneProductENSG00000106615 (Ensembl)
RICTORGeneProductENSG00000164327 (Ensembl)
RPS6KB1GeneProductENSG00000108443 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
RRAGAGeneProductENSG00000155876 (Ensembl)
RRAGBGeneProductENSG00000083750 (Ensembl)
RRAGCGeneProductENSG00000116954 (Ensembl)
RRAGDGeneProductENSG00000025039 (Ensembl)
RapamycinMetabolite5497196 (PubChem-compound)
Ribosome biogenesisPathway
SREPB2GeneProduct
TSC1GeneProductENSG00000165699 (Ensembl)
TSC2GeneProductENSG00000103197 (Ensembl)
ULK1GeneProductENSG00000177169 (Ensembl)
ULK2GeneProductENSG00000083290 (Ensembl)
ULK3GeneProductENSG00000140474 (Ensembl)
mRNA translationPathwayWP107 (WikiPathways)

Annotated Interactions

No annotated interactions

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