DNA replication (Mus musculus)

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1-3Cdt1UbiquitinOrc33. DNA replication initiationPhosphorylated Cdc6Mcm6Mcm7Mcm7Orc2Mcm 4,6,7 trimer forms andassociates with the replication forkOrc3Orc3RFC Heteropentamer:RNA primer-DNA primerPrimaseProcessive complexCdt1Pre-replicative complexDegraded by proteasome in cytosolOrc2Orc complex5. Leading/lagging strand synthesisOrc complexDNAPolymerase ARFC37Orc complexOrigin1. Assembly of the pre-replicative complexMcm2GemininDegraded byproteasomein cytosolOrc4RNA primer-DNA primerp180DNA polymerase alpha:primase: origin complexUbiquitinRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerCdt12. Activation of the pre-replicative complexMcm4Orc5RNA primer-DNA primer:origin duplex:PCNAOrc1Pre-replicative complexMcm2Ubiquitinated Cdc6Orc complexOrc4p49Ubiquitinated Orc1p70Cdt1RFC404. Switching of origins to post-replicative stateRNA PrimerCdc6Mcm5Mcm4Orc2p58Mcm10RFC140Orc complexPhosphorylation ofMcm 2-7 complexMcm3RNA primer-DNA primerMcm3Orc5Mcm6Orc2Cdc6Orc3DNA polymerase alpha:primase: origin complexOrc5RFC36Cdt1Phosphorylated Orc1Mcm5Cdc6Cdc6Mcm10RFC38Pold4Uba52GmnnPrim1Pole2Rpa1ATPdCTPOrc3lRpa3ATPRfc1Pold2Prim2Pola1dUTPPold3dGTPMcm3Orc1lCdc6Mcm6Cdt1PcnaCTPPold1UTPCdk2dATPRpa2ADPCdc7Rfc3Mcm5Rfc5Rfc2Pola2Mcm4Mcm7Cdc45lGTPPoleADPATPOrc6lOrc5lOrc2lMcm10Dbf4RPA4UbcOrc4lRfc4ATPMcm2


Description

DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "replication" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication. Source: [wikipedia:DNA_replication|Wikipedia]

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 72% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  3. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117872view10:19, 23 May 2021EweitzModified title
107197view14:28, 17 September 2019MaintBotChEBI identifier normalization
106854view13:33, 17 September 2019MaintBotHMDB identifier normalization
69148view18:17, 8 July 2013MaintBotUpdated to 2013 gpml schema
67160view10:14, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41336view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35196view15:36, 11 February 2010ThomasModified description
35195view15:35, 11 February 2010Thomasadded literature
34403view23:03, 9 December 2009MaintBotAutomatic update of empty xrefs
32866view17:56, 16 September 2009MaintBotAdded xrefs
32350view13:38, 15 August 2009MaintBotFixed text labels
31975view13:09, 14 August 2009MaintBotFixed group labels
31398view20:48, 13 August 2009MaintBotFixed text labels
30825view23:59, 29 July 2009MaintBotConverted from Homo sapiens
20997view11:30, 14 November 2008MaintBot[[Pathway:Mus musculus:DNA replication Reactome]] moved to [[Pathway:WP150]]: Moved to stable identifier
7992view13:46, 7 January 2008MaintBot[[Pathway:Mouse:DNA replication Reactome]] moved to [[Pathway:Mus musculus:DNA replication Reactome]]: Renaming species
7620view16:04, 18 December 2007MaintBotfixed category names
7210view12:33, 4 November 2007MaintBotAdded categories to GPML
19418view22:18, 22 May 2007D.Korengpml file for [[Mouse:DNA_replication_Reactome]]
6430view22:18, 22 May 2007Kdahlquistgpml file for [[Mouse:DNA_replication_Reactome]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteHMDB0001341 (HMDB)
ATPMetaboliteHMDB0001532 (HMDB)
CTPMetaboliteHMDB0000998 (HMDB)
Cdc45lGeneProduct12544 (Entrez Gene)
Cdc6GeneProduct23834 (Entrez Gene)
Cdc7GeneProduct12545 (Entrez Gene)
Cdk2GeneProduct12566 (Entrez Gene)
Cdt1GeneProduct67177 (Entrez Gene)
Dbf4GeneProduct27214 (Entrez Gene)
GTPMetaboliteHMDB0001440 (HMDB)
GmnnGeneProduct57441 (Entrez Gene)
Mcm10GeneProduct70024 (Entrez Gene)
Mcm2GeneProduct17216 (Entrez Gene)
Mcm3GeneProduct17215 (Entrez Gene)
Mcm4GeneProduct17217 (Entrez Gene)
Mcm5GeneProduct17218 (Entrez Gene)
Mcm6GeneProduct17219 (Entrez Gene)
Mcm7GeneProduct17220 (Entrez Gene)
Orc1lGeneProduct18392 (Entrez Gene)
Orc2lGeneProduct18393 (Entrez Gene)
Orc3lGeneProduct50793 (Entrez Gene)
Orc4lGeneProduct26428 (Entrez Gene)
Orc5lGeneProduct26429 (Entrez Gene)
Orc6lGeneProduct56452 (Entrez Gene)
PcnaGeneProduct18538 (Entrez Gene)
Pola1GeneProduct18968 (Entrez Gene)
Pola2GeneProduct18969 (Entrez Gene)
Pold1GeneProduct18971 (Entrez Gene)
Pold2GeneProduct18972 (Entrez Gene)
Pold3GeneProduct67967 (Entrez Gene)
Pold4GeneProduct69745 (Entrez Gene)
PoleGeneProduct18973 (Entrez Gene)
Pole2GeneProduct18974 (Entrez Gene)
Prim1GeneProduct19075 (Entrez Gene)
Prim2GeneProduct19076 (Entrez Gene)
RPA4GeneProduct
Rfc1GeneProduct19687 (Entrez Gene)
Rfc2GeneProduct19718 (Entrez Gene)
Rfc3GeneProduct69263 (Entrez Gene)
Rfc4GeneProduct106344 (Entrez Gene)
Rfc5GeneProduct72151 (Entrez Gene)
Rpa1GeneProduct68275 (Entrez Gene)
Rpa2GeneProduct19891 (Entrez Gene)
Rpa3GeneProduct68240 (Entrez Gene)
UTPMetaboliteCHEBI:17625 (ChEBI)
Uba52GeneProduct22186 (Entrez Gene)
UbcGeneProduct22190 (Entrez Gene)
dATPMetaboliteHMDB0001532 (HMDB)
dCTPMetaboliteHMDB0000998 (HMDB)
dGTPMetaboliteHMDB0001440 (HMDB)
dUTPMetaboliteCHEBI:17625 (ChEBI)

Annotated Interactions

No annotated interactions
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