daf-2 or insulin signaling pathway (Caenorhabditis elegans)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Stress resistanceLongevityDauerPDK-1DAF-2/INSRDAF-18/PTENAGE-1/PI-3KDAF-16/FOXOPIPSGK-1AKT-1AKT-2Name: daf-2 or insulin signaling pathwayOrganism: Caenorhabditis elegans


Description

Insulin receptor pathway in C. elegans

Initial version based on review by [Gami and Wolkow](https://www.ncbi.nlm.nih.gov/pubmed/16441841) of pathways that affect ageing.

The DAF-2 gene encodes for the insulin-like growth factor 1 (IGF-1) receptor in the worm Caenorhabditis elegans.

C. elegans with a diet of low glucose, reduced Daf-16 activity and worms lifespan was shortened compared to worms fed on media without glucose.

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Quality Tags

Image:Featured.pngFeatured version
Image:Curated.pngApproved version
Image:Wormbase.pngCommunity: WormBase

Ontology Terms

 

Bibliography

  1. Gami MS, Wolkow CA; ''Studies of Caenorhabditis elegans DAF-2/insulin signaling reveal targets for pharmacological manipulation of lifespan.''; Aging Cell, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137452
Featured
Approved
view13:11, 2 March 2025EgonwModified description
135383view08:12, 3 September 2024EgonwConverted to use Ensembl identifiers
106023view11:54, 16 August 2019MaintBotHMDB identifier normalization
102297view19:34, 17 December 2018KhanspersModified description
102296view19:34, 17 December 2018Khanspersfixed unconnected
96588view18:11, 22 March 2018Asios OliaModified description
96587view18:10, 22 March 2018Asios OliaModified description
72339
WormBase
view22:07, 8 November 2013KyookOntology Term : 'insulin-like growth factor signaling pathway' added !
70500view00:19, 8 August 2013CgroveConnecting lines
70499view00:17, 8 August 2013CgroveConnected lines
68474view20:37, 5 July 2013MaintBotUpdated to 2013 gpml schema
67143view10:12, 26 June 2013Christine ChichesterOntology Term : 'aging pathway' added !
40626view19:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
32939view06:17, 24 September 2009Pieter GiesbertzConnected lines
32817view13:34, 9 September 2009Pieter GiesbertzUpdated title
31983view13:12, 14 August 2009MaintBotFixed group labels
29668view16:07, 25 May 2009MartijnVanIerselAnnotated node
28739view12:27, 2 March 2009MartijnVanIerselCorrected identifiers
20709view11:29, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:daf-2 or insuling signaling pathway]] moved to [[Pathway:WP17]]: Moved to stable identifier
11859view09:16, 7 May 2008MartijnVanIerselModified categories
10674view12:51, 21 February 2008MartijnVanIerseladded annotation for all genes
10669view12:45, 21 February 2008MartijnVanIerselModified description
10666view12:43, 21 February 2008MartijnVanIerselSpecify description
10665view12:41, 21 February 2008MartijnVanIersellabels
10664view12:39, 21 February 2008MartijnVanIerseladded connectors
10662view12:31, 21 February 2008MartijnVanIerseladded main genes
10659view12:29, 21 February 2008MartijnVanIerselfirst version

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AGE-1/PI-3KGeneProductWBGene00000090 (Ensembl)
AKT-1GeneProductWBGene00000102 (Ensembl)
AKT-2GeneProductWBGene00000103 (Ensembl)
DAF-16/FOXOGeneProductWBGene00000912 (Ensembl)
DAF-18/PTENGeneProductWBGene00000913 (Ensembl)
DAF-2/INSRGeneProductWBGene00000898 (Ensembl)
PDK-1GeneProductWBGene00003965 (Ensembl)
PIPMetaboliteHMDB0004249 (HMDB)
SGK-1GeneProductWBGene00004789 (Ensembl)

Annotated Interactions

No annotated interactions

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