Insulin-like Growth Factor-2 mRNA Binding Proteins binding to RNA (Homo sapiens)

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Bibliography

1. Weidensdorfer D, Stöhr N, Baude A, Lederer M, Köhn M, Schierhorn A, Buchmeier S, Wahle E, Hüttelmaier S.; ''Control of c-myc mRNA stability by IGF2BP1-associated cytoplasmic RNPs.''; PubMed Europe PMC Scholia
2. Runge S, Nielsen FC, Nielsen J, Lykke-Andersen J, Wewer UM, Christiansen J.; ''H19 RNA binds four molecules of insulin-like growth factor II mRNA-binding protein.''; PubMed Europe PMC Scholia
3. Noubissi FK, Elcheva I, Bhatia N, Shakoori A, Ougolkov A, Liu J, Minamoto T, Ross J, Fuchs SY, Spiegelman VS.; ''CRD-BP mediates stabilization of betaTrCP1 and c-myc mRNA in response to beta-catenin signalling.''; PubMed Europe PMC Scholia
4. Christiansen J, Kolte AM, Hansen Tv, Nielsen FC.; ''IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes.''; PubMed Europe PMC Scholia
5. Hüttelmaier S, Zenklusen D, Lederer M, Dictenberg J, Lorenz M, Meng X, Bassell GJ, Condeelis J, Singer RH.; ''Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1.''; PubMed Europe PMC Scholia
6. Nielsen FC, Nielsen J, Christiansen J.; ''A family of IGF-II mRNA binding proteins (IMP) involved in RNA trafficking.''; PubMed Europe PMC Scholia
7. Yisraeli JK.; ''VICKZ proteins: a multi-talented family of regulatory RNA-binding proteins.''; PubMed Europe PMC Scholia
8. Lemm I, Ross J.; ''Regulation of c-myc mRNA decay by translational pausing in a coding region instability determinant.''; PubMed Europe PMC Scholia
9. Oberman F, Rand K, Maizels Y, Rubinstein AM, Yisraeli JK.; ''VICKZ proteins mediate cell migration via their RNA binding activity.''; PubMed Europe PMC Scholia
10. Vikesaa J, Hansen TV, Jønson L, Borup R, Wewer UM, Christiansen J, Nielsen FC.; ''RNA-binding IMPs promote cell adhesion and invadopodia formation.''; PubMed Europe PMC Scholia
11. Groenewoud MJ, Dekker JM, Fritsche A, Reiling E, Nijpels G, Heine RJ, Maassen JA, Machicao F, Schäfer SA, Häring HU, 't Hart LM, van Haeften TW.; ''Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.''; PubMed Europe PMC Scholia
12. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T.; ''Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.''; PubMed Europe PMC Scholia
13. Nielsen J, Christiansen J, Lykke-Andersen J, Johnsen AH, Wewer UM, Nielsen FC.; ''A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development.''; PubMed Europe PMC Scholia
14. Chao JA, Patskovsky Y, Patel V, Levy M, Almo SC, Singer RH.; ''ZBP1 recognition of beta-actin zipcode induces RNA looping.''; PubMed Europe PMC Scholia
15. Ioannidis P, Mahaira L, Papadopoulou A, Teixeira MR, Heim S, Andersen JA, Evangelou E, Dafni U, Pandis N, Trangas T.; ''CRD-BP: a c-Myc mRNA stabilizing protein with an oncofetal pattern of expression.''; PubMed Europe PMC Scholia

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External references

DataNodes

Name	Type	Database reference	Comment
Beta-actin mRNA isoform 001	Protein	ENST00000331789 (Ensembl)
CD44 mRNA isoform 201	Protein	ENST00000263398 (Ensembl)
CD44 mRNA isoform 202	Protein	ENST00000278385 (Ensembl)
CD44 mRNA isoform 203	Protein	ENST00000278386 (Ensembl)
CD44 mRNA isoform 204	Protein	ENST00000279452 (Ensembl)
CD44 mRNA isoform 205	Protein	ENST00000352818 (Ensembl)
H19 noncoding RNA	Protein	ENST00000252900 (Ensembl)
IGF2-001 mRNA	Protein	ENST00000381406 (Ensembl)
IGF2-002 mRNA	Protein	ENST00000337883 (Ensembl)
IGF2BP1	Protein	Q9NZI8 (Uniprot-TrEMBL)
IGF2BP1:RNA	Complex	R-HSA-428327 (Reactome)
IGF2BP1	Protein	Q9NZI8 (Uniprot-TrEMBL)
IGF2BP2	Protein	Q9Y6M1 (Uniprot-TrEMBL)
IGF2BP2:RNA	Complex	R-HSA-428335 (Reactome)
IGF2BP2	Protein	Q9Y6M1 (Uniprot-TrEMBL)
IGF2BP3	Protein	O00425 (Uniprot-TrEMBL)
IGF2BP3:RNA	Complex	R-HSA-428310 (Reactome)
IGF2BP3	Protein	O00425 (Uniprot-TrEMBL)
MYC mRNA	Protein	ENST00000613283 (Ensembl)
RNAs bound by IGF2BP1	Complex	R-HSA-428308 (Reactome)
RNAs bound by IGF2BP2	Complex	R-HSA-428328 (Reactome)
RNAs bound by IGF2BP3	Complex	R-HSA-428384 (Reactome)

Annotated Interactions

Source	Target	Type	Database reference	Comment
	IGF2BP1:RNA	Arrow	R-HSA-428296 (Reactome)
IGF2BP1			R-HSA-428296 (Reactome)
	IGF2BP2:RNA	Arrow	R-HSA-428293 (Reactome)
IGF2BP2			R-HSA-428293 (Reactome)
	IGF2BP3:RNA	Arrow	R-HSA-428287 (Reactome)
IGF2BP3			R-HSA-428287 (Reactome)
			R-HSA-428287 (Reactome)	Insulin-like Growth Factor mRNA Binding Factor-3 (IGF2BP3, also known as IMP3 and VICKZ3) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA. Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP3 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).
			R-HSA-428293 (Reactome)	Insulin-like Growth Factor mRNA Binding Factor-2 (IGF2BP2, also known as IMP2 and VICKZ2) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA. Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP2 at the 5' UTR, repressing translation (Other isoforms of IGF2 are constitutive). IGF2BP2 may be a causal factor in type 2 diabetes.
			R-HSA-428296 (Reactome)	Insulin-like Growth Factor mRNA Binding Factor-1 (IGF2BP1, also known as ZBP1, CRD-BP, IMP1, and VICKZ1) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA. Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP1 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive). ZBP1 (IGF2BP1) uses its third and fourth KH domains to recognize the first 28 nts of the 3' UTR of Beta actin mRNA. The KH domains are arranged as an anti-parallel pseudo-dimer that specifically recognize a bipartite element located in this RNA sequence. MYC (c-MYC) and Beta-TRCP1 mRNAs are bound at sites termed Coding Region Determinants (CDRs) in the open reading frame of the message. Binding of the MYC mRNA shields it from degradation and increases its half-life The CD44 mRNA is bound at the 3' UTR. IGF2BP1 also binds the non-coding, imprinted H19 RNA.
RNAs bound by IGF2BP1			R-HSA-428296 (Reactome)
RNAs bound by IGF2BP2			R-HSA-428293 (Reactome)
RNAs bound by IGF2BP3			R-HSA-428287 (Reactome)