Effects of nitric oxide (Homo sapiens)

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1, 2HypoxiaIncreasedmitochondrialefficiency3reduced risk ofcarciovascular diseasecGMPsignallingVasodilationanti-inflammatoryeffectsNOS familyIncreased riskof carcinogenesisformation ofnitrosilatingspeciesNOS3 (endothelial)Nitric oxideAOX1deoxy-hemoglobindeoxy-myoglobinNitrateNOS1 (neuronal)COX1NOS2 (inducible)CitrullineVItamin CNitriteXDHL-ArginineOxygenDiet


NO (Nitric oxide) is an important signalling molecule with vasodilatory and anti-inflammatory effects, indicating a postive role in reducing hypertension and cardiovascular disease. At the same time, NO is also associated with health risks such as increased risk in carcinogenesis, and hypoxia in infants. It has been suggested that NO can also increase mitochondrial efficiency. NO can be formed from L-Arginine through the classic Arginine-NO-Synthase pathway, or it can be formed directly from dietary nitrite by deoxiginated globins.

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  1. Hord NG, Tang Y, Bryan NS; ''Food sources of nitrates and nitrites: the physiologic context for potential health benefits.''; Am J Clin Nutr, 2009 PubMed Europe PMC Scholia
  2. Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR Jr, Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, Weitzberg E; ''Nitrate and nitrite in biology, nutrition and therapeutics.''; Nat Chem Biol, 2009 PubMed Europe PMC Scholia
  3. Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E; ''Dietary inorganic nitrate improves mitochondrial efficiency in humans.''; Cell Metab, 2011 PubMed Europe PMC Scholia


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116455view09:57, 7 May 2021EweitzModified title
106705view13:13, 17 September 2019MaintBotHMDB identifier normalization
88595view19:44, 11 August 2016Mkutmonfix unconnected lines
69910view19:35, 11 July 2013AlexanderPicoReplaced datanodes with labels
69907view19:32, 11 July 2013AlexanderPicoModified title
63176view20:30, 8 May 2013MaintBotUpdating gpml version
59194view19:07, 22 February 2013MaintBotUpdated Ensembl and UniProt data source
44467view20:13, 14 September 2011MaintBotModified categories
43380view13:50, 17 June 2011MartijnVanIerselModified description
43379view13:43, 17 June 2011MartijnVanIerselOntology Term : 'cardiovascular system homeostasis pathway' added !
43377view13:41, 17 June 2011MartijnVanIersellitrefs
43372view11:22, 17 June 2011MartijnVanIerselvarious
43371view11:14, 17 June 2011MartijnVanIerselNew pathway

External references


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NameTypeDatabase referenceComment
AOX1ProteinENSG00000138356 (Ensembl)
COX1GeneProduct4512 (Entrez Gene)
CitrullineMetaboliteHMDB0000904 (HMDB)
L-ArginineMetaboliteHMDB0000517 (HMDB)
NOS1 (neuronal)GeneProduct4842 (Entrez Gene)
NOS2 (inducible)GeneProduct4843 (Entrez Gene)
NOS3 (endothelial)GeneProduct4846 (Entrez Gene)
NitrateMetaboliteHMDB0002878 (HMDB)
Nitric oxideMetaboliteHMDB0003378 (HMDB)
NitriteMetaboliteHMDB0002786 (HMDB)
OxygenMetaboliteHMDB0001377 (HMDB)
VItamin CMetaboliteHMDB0000044 (HMDB)
XDHGeneProductENSG00000158125 (Ensembl)
deoxy-hemoglobinGeneProductENSG00000206172 (Ensembl)
deoxy-myoglobinGeneProduct4151 (Entrez Gene)

Annotated Interactions

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