EGF signaling in vulval development (Caenorhabditis elegans)

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Description

EGF signaling is a key pathway involved in vulval patterning. Vulval precursor cell patterning requires input and cooperation between both EGF LIN-3 graded signaling through LET-23 as well as a sequential, subordinate signal involving DSL ligands acting via LIN-12. See figure 8 here: http://www.wormbook.org/chapters/www_vulvaldev/vulvaldev.pdf

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Quality Tags

Ontology Terms

 

Bibliography

  1. Sternberg PW; ''Vulval development.''; WormBook, 2005 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135393view15:36, 3 September 2024EgonwConverted to use Ensembl identifiers
135298view21:03, 15 August 2024KhanspersModified description
135297view21:02, 15 August 2024Khansperstidy and fix interactions
118368view13:47, 27 May 2021RaatsSfixed unconnected lines
118059view10:37, 24 May 2021EweitzModified title
118058view10:37, 24 May 2021EweitzModified title
68492view20:59, 5 July 2013MaintBotUpdated to 2013 gpml schema
67173view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
49039view19:05, 3 July 2012KyookOntology Term : 'Ras mediated signaling pathway' added !
48969view19:02, 2 July 2012KyookModified description
48968view19:02, 2 July 2012KyookOntology Term : 'EGF/neuregulin signaling pathway' added !
48948view15:53, 30 June 2012MaintBotModified categories
48933view21:42, 29 June 2012Kyookfinished pathway
48932view21:40, 29 June 2012KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
LET-23GeneProductWBGene00002299 (Ensembl)
LET-60GeneProductWBGene00002335 (Ensembl)
LIN-1GeneProductWBGene00002990 (Ensembl)
LIN-31GeneProductWBGene00003017 (Ensembl)
LIN-3GeneProductWBGene00002992 (Ensembl)
LIN-45GeneProductWBGene00003030 (Ensembl)
MEK-2GeneProductWBGene00003186 (Ensembl)
MPK-1GeneProductWBGene00003401 (Ensembl)
SEM-5GeneProductWBGene00004774 (Ensembl)
SOS-1GeneProductWBGene00004947 (Ensembl)
egl-17GeneProductWBGene00001185 (Ensembl)
lin-39GeneProductWBGene00003024 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2221"