Under aerobic conditions, S. cerevisiae is able to utilize glycerol as a sole carbon and energy source. Glycerol degradation is a two-step process; the first step of glycerol phosphorylation occurs in the cytosol, then glycerol-3-phosphate enters the mitochondrion where the second step of conversion to dihydroxyacetone is catalyzed. Dihydroxyacetone is then returned to the cytosol where it enters into either glycolysis or gluconeogenesis. The genes encoding the enzymes catalyzing glycerol catabolism, GUT1 and GUT2, are carbon source regulated; gene expression is repressed when cells are grown on fermentable carbon sources such as glucose and up-regulated on non-fermentable carbon sources such as glycerol or ethanol.
Description source: [YeastPathways](https://pathway.yeastgenome.org/).
Please help improve this pathway by editing the description. You are allowed to use literature references as a source of inspiration, however please write your own text. Remove this tag when completed.
Add references
Please help improve this pathway by adding literature references. Remove this tag when completed.
Approved version
The current version of this pathway was approved for data analysis by Kristina Hanspers.
Annotate nodes
Comment: 6 out of 36 DataNodes have a missing external reference. Check DataNode table at the bottom of the page.
Please help improve this pathway by annotating gene, protein and metabolite nodes.
Saving...
