Synaptic vesicle pathway (Homo sapiens)

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Vesicle releaseMonoaminesSynapsin P+CytoskeletonRAB3AATPL-GlutamineDopamineSYN1SYN2SYN3SYT1VAMP2Early vesicle traffickingAnterograde transportfrom the trans-GolginetworkPresynaptic membraneSTX1BSTX2STX1ASTX3SNAP25Active zone T-SNARESRIMS1STXBP1RAB3ADockingUNC13CPrimingUNC13BUNC13ACPLX3CPLX2CPLX1NSF attachment proteinsNAPANSFCa2+CACNA1ACACNA1BRAB3ASynaptic cleft(upon depolarization)ADPFusionSYPPoreformationCa2+DNM1DNM1LDNM2DNM3CLTACLTCCLTCL1AP2S1AP2A1AP2A2AP2B1AP2M1EndocytosisSLC32A1SLC17A8SLC17A7SLC17A6SLC18A1SLC18A2SLC18A3Neurotransmitter uptakeNeurotransmitterSLC32A1SLC22A3SLC38A1PARK7SLC1A3CLN8SerotoninSLC6A4SLC25A4GlutamateATP1A2Neurotransmitter


Description

Pathway depicting synaptic transmission of neurotransmitters from the presynaptic nerve terminal to the synaptic cleft upon depolarization. Synaptotagmin mediated transport along the nerve cell cytoskeleton indicates the initial step of this process. Originally created by Joanna S. Fong and Nathan Salomonis in the Bruce Conklin laboratory 5/12/2000 for use in GenMAPP. Genes associated with neurotransmitter reuptake from the synaptic left were obtained from the Gene Ontology term GO:0001504. For additional information see: http://en.wikipedia.org/wiki/Synaptic_vesicle. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
128068view00:24, 24 January 2024EweitzOntology Term : 'neuron' added !
128067view00:11, 24 January 2024EweitzFix typo, reduce text overlap, standardize case
117179view09:58, 18 May 2021EweitzModified title
106709view13:14, 17 September 2019MaintBotHMDB identifier normalization
106480view19:44, 3 September 2019KhanspersModified description
105830view23:07, 15 August 2019KhanspersModified description
96972view13:59, 24 April 2018Fehrhartinteractions to graphical lines
96721view12:08, 31 March 2018EgonwConverted the Ca2+ labels to Metabolite DataNodes with Xrefs.
85090view23:48, 12 April 2016EgonwAdded a few metabolite identifiers.
78595view14:51, 7 January 2015MaintBotadded missing graphIds
68907view17:30, 8 July 2013MaintBotUpdated to 2013 gpml schema
61690view22:19, 16 April 2013MaintBotremoved data source without identifer
59106view22:20, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
56444view21:42, 7 January 2013EgonwAdded a missing HMDB data source value.
53133view01:53, 30 October 2012MaintBotModified categories
50424view20:45, 15 August 2012NsalomonisSpecify description
50423view20:42, 15 August 2012NsalomonisSpecify description
50422view20:37, 15 August 2012NsalomonisModified description
50421view20:34, 15 August 2012NsalomonisSpecify description
50420view20:31, 15 August 2012NsalomonisSpecify description
50419view20:28, 15 August 2012NsalomonisPeriodical save, work in progress
50418view20:18, 15 August 2012NsalomonisPeriodical save, work in progress
50411view18:56, 15 August 2012NsalomonisSpecify description
50339view21:12, 12 August 2012NsalomonisOntology Term : 'synaptic vesicle cycle pathway' added !
50338view21:11, 12 August 2012NsalomonisModified description
50337view21:10, 12 August 2012NsalomonisModified description
50336view20:55, 12 August 2012NsalomonisSpecify description
50335view20:53, 12 August 2012NsalomonisPeriodical save, work in progress
50334view20:43, 12 August 2012NsalomonisPeriodical save, work in progress
50333view20:36, 12 August 2012NsalomonisSpecify description
50332view20:33, 12 August 2012NsalomonisPeriodical save, work in progress
50331view20:22, 12 August 2012NsalomonisPeriodical save, work in progress
50330view20:19, 12 August 2012NsalomonisSpecify description
50329view20:16, 12 August 2012NsalomonisSpecify description
50328view20:12, 12 August 2012NsalomonisPeriodical save, work in progress
50327view20:11, 12 August 2012NsalomonisSpecify description
50324view20:02, 12 August 2012NsalomonisPeriodical save, work in progress
50321view19:59, 12 August 2012NsalomonisSpecify description
50320view19:52, 12 August 2012NsalomonisPeriodical save, work in progress
50319view19:47, 12 August 2012NsalomonisSpecify description
50318view19:42, 12 August 2012NsalomonisPeriodical save, work in progress
50317view19:32, 12 August 2012NsalomonisPeriodical save, work in progress
50316view19:21, 12 August 2012NsalomonisSpecify description
50313view19:02, 12 August 2012NsalomonisPeriodical save, work in progress
50312view18:52, 12 August 2012NsalomonisPeriodical save, work in progress
50311view18:42, 12 August 2012NsalomonisPeriodical save, work in progress
50310view18:31, 12 August 2012NsalomonisNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetaboliteCHEBI:16761 (ChEBI)
AP2A1GeneProductENSG00000196961 (Ensembl)
AP2A2GeneProductENSG00000183020 (Ensembl)
AP2B1GeneProductENSG00000006125 (Ensembl)
AP2M1GeneProductENSG00000161203 (Ensembl)
AP2S1GeneProductENSG00000042753 (Ensembl)
ATP1A2GeneProductENSG00000018625 (Ensembl)
ATPMetaboliteCHEBI:15422 (ChEBI)
CACNA1AGeneProductENSG00000141837 (Ensembl)
CACNA1BGeneProductENSG00000148408 (Ensembl)
CLN8GeneProductENSG00000182372 (Ensembl)
CLTAGeneProductENSG00000122705 (Ensembl)
CLTCGeneProductENSG00000141367 (Ensembl)
CLTCL1GeneProductENSG00000070371 (Ensembl)
CPLX1GeneProductENSG00000168993 (Ensembl)
CPLX2GeneProductENSG00000145920 (Ensembl)
CPLX3GeneProductENSG00000213578 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
DNM1GeneProductENSG00000106976 (Ensembl)
DNM1LGeneProductENSG00000087470 (Ensembl)
DNM2GeneProductENSG00000079805 (Ensembl)
DNM3GeneProductENSG00000197959 (Ensembl)
DopamineMetaboliteHMDB0000073 (HMDB)
GlutamateMetaboliteCHEBI:29987 (ChEBI)
L-GlutamineMetaboliteHMDB0000641 (HMDB)
NAPAGeneProductENSG00000105402 (Ensembl)
NSFGeneProductENSG00000073969 (Ensembl)
PARK7GeneProductENSG00000116288 (Ensembl)
RAB3AGeneProductENSG00000105649 (Ensembl)
RIMS1GeneProductENSG00000079841 (Ensembl)
SLC17A6GeneProductENSG00000091664 (Ensembl)
SLC17A7GeneProductENSG00000104888 (Ensembl)
SLC17A8GeneProductENSG00000179520 (Ensembl)
SLC18A1GeneProductENSG00000036565 (Ensembl)
SLC18A2GeneProductENSG00000165646 (Ensembl)
SLC18A3GeneProductENSG00000187714 (Ensembl)
SLC1A3GeneProductENSG00000079215 (Ensembl)
SLC22A3GeneProductENSG00000146477 (Ensembl)
SLC25A4GeneProductENSG00000151729 (Ensembl)
SLC32A1GeneProductENSG00000101438 (Ensembl)
SLC38A1GeneProductENSG00000111371 (Ensembl)
SLC6A4GeneProductENSG00000108576 (Ensembl)
SNAP25GeneProductENSG00000132639 (Ensembl)
STX1AGeneProductENSG00000106089 (Ensembl)
STX1BGeneProductENSG00000099365 (Ensembl)
STX2GeneProductENSG00000111450 (Ensembl)
STX3GeneProductENSG00000166900 (Ensembl)
STXBP1GeneProductENSG00000136854 (Ensembl)
SYN1GeneProductENSG00000008056 (Ensembl)
SYN2GeneProductENSG00000157152 (Ensembl)
SYN3GeneProductENSG00000185666 (Ensembl)
SYPGeneProductENSG00000102003 (Ensembl)
SYT1GeneProductENSG00000067715 (Ensembl)
SerotoninMetaboliteHMDB0000259 (HMDB)
UNC13AGeneProductENSG00000130477 (Ensembl)
UNC13BGeneProductENSG00000198722 (Ensembl)
UNC13CGeneProductENSG00000137766 (Ensembl)
VAMP2GeneProductENSG00000220205 (Ensembl)

Annotated Interactions

No annotated interactions

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