TNF-alpha NF-kB signaling pathway (Mus musculus)

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UbiquitinationGOCY ->NUDesumoylationProteolytic cleavageDPMPalmitoylationNURecruitmentCytoplasmCYMTInhibitionProteins in a complex interactionActivationCY ->NUENLigandControlERReaction through unknown mechanisms/moleculesGolgi apparatusEndosome(Protein-protein interaction)CY ->NUCY ->NUEndoplasmic reticulumMethylationPlasma membraneAutophosphorylationAcetylationEnzyme complexGlycosylationSumoylationMolecular associationDeubiquitinationReceptorPhosphorylationMitochondrionAccession Number: NetPath 9; cellmap:9ECNucleusDeacetylationTranslocationMolecule in the pathwayDemethylationCY ->NUExtracellularDephosphorylationTnfrsf1bTifaTnip2Ube2iMap3k3Rasal2Fkbp5Iqgap2TnfTraf2Gab1Psmc2Cul1Akap8Peg3CyldUsp11Ppp1r13lDpf2TankRnf25Ripk3Psmd7Kpna3Zfand5GeneNlrp4eSmarca4Smarcb1Ddx3xPsmc3RPL6IkbkeTnfrsf8Polr1aCasp8ap2RPL8Pkn1TxlnaGsk3bHdac2RelbRelFlnaRelaMap2k5AlplPsmb5Hdac6RelaPias3Map3k3Smarce1CraddRPL30Polr1dPebp1FaddGm4596Usp2Map3k7ip3Cops3GeneCasp8IkbkgNfkbieNkiras1Tnfaip3UBCH5BBcl3NfkbiaAzi2Gm2423Map3k8Ktn1Map3k14Glg1Nfkb2Trpc4apMap3k7ip1Psmd12Kpna6Nfkb1Pfdn2SrcTraf4Eif4a3Psmd6PmlCasp2Gtf2iRelaChukPsmc1G3bp2Akt1Bag4Casp7Cd3eapHIST3H3Polr2hKPNA2PapolaSKP1APtk2Mark2CSNK2A1Map3k7ip2Polr1cGeneKcnq1DapTraddTnfMcm5Tnfrsf1aSmarcc1IkbkbFblGm10774Nr2c2SUMO1Traf1IkbkgYwhaeBCL7APsmd13Rps6ka5Ripk2Tbk1Commd1Hdac1Tnfrsf1aRPS13Birc3MCCNfkbiaNfkbibNr2c2PrkczGeneTraf2Traf4RelChukBirc2Rps11Traf1Cdc37Actl6aTnip1Ppp2caMtif2TnfRipk1Hsp90ab1Traf6Tnfrsf1bPdcd2TnfNfkb1RelaTraf5Nkiras2YwhabUnc5cl2610301G19RikIkbkapNfkbiaMap3k1Mcm7Birc3Nfkb1Traf2Cdc34TnfCapn3LrpprcCasp3Psmd1Csnk2a2NsmafCASP10TraddNfkbizTbk1Akt2Rnf216Map3k2Birc2Tnfrsf1bTraf3Tnfrsf1aPsmd3YwhazCflarCav1Rpl4TnfFbxw11Ptpn11Faf1TraipFancd2Polr1eCsnk2bBtrcRPS6KB1CrebbpTnfrsf11aPolr1bRipk1Gnb2l1RelbSmarcc2YwhagGene SymbolStat1Hsp90aa1Hspb1PrkacaWdr68Ywhah


Description

NetPath 9 ; cellmap:9 - TNF-alpha/NF-kB Signaling Pathway This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, please cite the Cancer Cell Map and NetPath websites until the pathway is published.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP231(r28972) with a 91% conversion rate.

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Quality Tags

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
118927view14:51, 4 June 2021EgonwModified description
118924view11:15, 4 June 2021Mkutmonupdate description
118923view11:15, 4 June 2021Mkutmonupdate description
116715view09:56, 11 May 2021EweitzModified title
69201view18:24, 8 July 2013MaintBotUpdated to 2013 gpml schema
67701view11:51, 26 June 2013DdiglesOntology Term : 'tumor necrosis factor mediated signaling pathway' added !
41391view00:29, 2 March 2011MaintBotRemoved redundant pathway information and comments
34428view23:23, 9 December 2009MaintBotAutomatic update of empty xrefs
32375view16:51, 15 August 2009MaintBotFixed text labels
32011view13:20, 14 August 2009MaintBotFixed group labels
31412view20:54, 13 August 2009MaintBotFixed text labels
30882view00:17, 30 July 2009MaintBotConverted from Homo sapiens
21197view11:31, 14 November 2008MaintBot[[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:WP246]]: Moved to stable identifier
8448view13:46, 7 January 2008MaintBot[[Pathway:Mouse:TNF-alpha-NF-kB NetPath 9]] moved to [[Pathway:Mus musculus:TNF-alpha-NF-kB NetPath 9]]: Renaming species
7840view16:22, 18 December 2007MaintBotfixed category names
7308view12:42, 4 November 2007MaintBotAdded categories to GPML
6503view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:TNF-alpha-NF-kB_NetPath_9]]

External references

DataNodes

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NameTypeDatabase referenceComment
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Azi2GeneProduct27215 (Entrez Gene)
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CASP10GeneProduct
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Casp7GeneProduct12369 (Entrez Gene)
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Casp8ap2GeneProduct26885 (Entrez Gene)
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Cdc34GeneProduct216150 (Entrez Gene)
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Hsp90ab1GeneProduct15516 (Entrez Gene)
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Iqgap2GeneProduct544963 (Entrez Gene)
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Map3k2GeneProduct26405 (Entrez Gene)
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Map3k7ip1GeneProduct66513 (Entrez Gene)
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Nfkb1GeneProduct18033 (Entrez Gene)
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Nlrp4eGeneProduct446099 (Entrez Gene)
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NsmafGeneProduct18201 (Entrez Gene)
PapolaGeneProduct18789 (Entrez Gene)
Pdcd2GeneProduct18567 (Entrez Gene)
Pebp1GeneProduct23980 (Entrez Gene)
Peg3GeneProduct18616 (Entrez Gene)
Pfdn2GeneProduct18637 (Entrez Gene)
Pias3GeneProduct229615 (Entrez Gene)
Pkn1GeneProduct320795 (Entrez Gene)
PmlGeneProduct18854 (Entrez Gene)
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Polr1bGeneProduct20017 (Entrez Gene)
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Polr1dGeneProduct20018 (Entrez Gene)
Polr1eGeneProduct64424 (Entrez Gene)
Polr2hGeneProduct245841 (Entrez Gene)
Ppp1r13lGeneProduct333654 (Entrez Gene)
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PrkacaGeneProduct18747 (Entrez Gene)
PrkczGeneProduct18762 (Entrez Gene)
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Psmd3GeneProduct22123 (Entrez Gene)
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Psmd7GeneProduct17463 (Entrez Gene)
Ptk2GeneProduct14083 (Entrez Gene)
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RPL30GeneProduct19946 (Entrez Gene)
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RPL8GeneProduct26961 (Entrez Gene)
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Rasal2GeneProduct226525 (Entrez Gene)
RelGeneProduct19696 (Entrez Gene)
RelaGeneProduct19697 (Entrez Gene)
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Ripk1GeneProduct19766 (Entrez Gene)
Ripk2GeneProduct192656 (Entrez Gene)
Ripk3GeneProduct56532 (Entrez Gene)
Rnf216GeneProduct108086 (Entrez Gene)
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Rps11GeneProduct27207 (Entrez Gene)
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SKP1AGeneProduct21402 (Entrez Gene)
SUMO1GeneProduct22218 (Entrez Gene)
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Smarcb1GeneProduct20587 (Entrez Gene)
Smarcc1GeneProduct20588 (Entrez Gene)
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Smarce1GeneProduct57376 (Entrez Gene)
SrcGeneProduct20779 (Entrez Gene)
Stat1GeneProduct20846 (Entrez Gene)
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UBCH5BGeneProduct
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YwhagGeneProduct22628 (Entrez Gene)
YwhahGeneProduct22629 (Entrez Gene)
YwhazGeneProduct22631 (Entrez Gene)
Zfand5GeneProduct22682 (Entrez Gene)

Annotated Interactions

No annotated interactions
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