PDGF pathway (Homo sapiens)

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Description

PDGF belongs to the PDGF/VEGF (vascular endothelial growth factor) family, which is characterized by eight strictly conserved cysteine residues with similar spacing in between (Joukov et al., 1997; Heldin and Westermark, 1999). The A-, B-, C-, and D-chain genes of PDGF are localized to the chromosomes 7p22, 22q13, 4q31, and 11q22, respectively, and their expression is independently regulated. Two forms of the PDGF A-chain, containing 196 and 211 amino acid residues resulting from differential splicing of the transcript, are synthesized, dimerized, proteolytically processed in the Nterminus, and secreted from the cell as a ~30 kDa dimer. The PDGF B chain encoding 241 amino acid residues is dimerized, processed by additional proteolysis, and secreted as a 24 kDa dimer. The homodimers PDGF AA, BB, and the heterodimer AB contain three intrachain disulfide bonds.


Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP2526).

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Hannink M, Donoghue DJ; ''Structure and function of platelet-derived growth factor (PDGF) and related proteins.''; Biochim Biophys Acta, 1989 PubMed Europe PMC Scholia
  2. Smith CL, Tallquist MD; ''PDGF function in diverse neural crest cell populations.''; Cell Adh Migr, 2010 PubMed Europe PMC Scholia
  3. Heldin CH; ''Autocrine PDGF stimulation in malignancies.''; Ups J Med Sci, 2012 PubMed Europe PMC Scholia
  4. Claesson-Welsh L, Heldin CH; ''Platelet-derived growth factor. Three isoforms that bind to two distinct cell surface receptors.''; Acta Oncol, 1989 PubMed Europe PMC Scholia
  5. Kawahara RS, Deng ZW, Deuel TF; ''PDGF and the small inducible gene (SIG) family: roles in the inflammatory response.''; Adv Exp Med Biol, 1991 PubMed Europe PMC Scholia
  6. Heldin CH, Hammacher A, Nistأ©r M, Westermark B; ''Structural and functional aspects of platelet-derived growth factor.''; Br J Cancer, 1988 PubMed Europe PMC Scholia
  7. Farooqi AA, Waseem S, Riaz AM, Dilawar BA, Mukhtar S, Minhaj S, Waseem MS, Daniel S, Malik BA, Nawaz A, Bhatti S; ''PDGF: the nuts and bolts of signalling toolbox.''; Tumour Biol, 2011 PubMed Europe PMC Scholia
  8. Antoniades HN; ''PDGF: a multifunctional growth factor.''; Baillieres Clin Endocrinol Metab, 1991 PubMed Europe PMC Scholia
  9. Heldin CH, Westermark B; ''Platelet-derived growth factors: a family of isoforms that bind to two distinct receptors.''; Br Med Bull, 1989 PubMed Europe PMC Scholia
  10. Andrae J, Gallini R, Betsholtz C; ''Role of platelet-derived growth factors in physiology and medicine.''; Genes Dev, 2008 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
140649view06:17, 28 September 2025EgonwRemoved unfinished part of the sentence
139970view04:45, 14 July 2025EgonwMore unicode
137646view11:42, 6 March 2025EweitzUse gene symbols
137645view11:36, 6 March 2025EweitzEconomize layout
137644view11:29, 6 March 2025EweitzStandardize case
137643view02:21, 6 March 2025EweitzTailor custom node dimensions
137642view02:17, 6 March 2025EweitzTailor node dimensions
137641view02:07, 6 March 2025EweitzEconomize layout
137640view02:05, 6 March 2025EweitzEconomize layout
137639view01:47, 6 March 2025EweitzEconomize layout
137638view01:40, 6 March 2025EweitzEconomize layout
137637view01:36, 6 March 2025EweitzEconomize layout
137636view01:17, 6 March 2025EweitzUse gene symbols
137635view00:57, 6 March 2025EweitzEconomize layout
137578view12:57, 4 March 2025EweitzIncrease font size
137577view12:54, 4 March 2025EweitzUse simpler, straighter lines for interactions
137576view12:49, 4 March 2025EweitzUse simpler, straighter lines for interactions
137107view22:57, 27 February 2025KhanspersModified description
123068view04:20, 23 June 2022EgonwMade a pathway clickable
121697view03:35, 26 February 2022EweitzUse official gene symbol
117815view14:48, 22 May 2021EweitzModified title
107132view14:21, 17 September 2019MaintBotChEBI identifier normalization
106717view13:15, 17 September 2019MaintBotHMDB identifier normalization
106552view00:13, 6 September 2019KhanspersModified description
105476view05:22, 8 August 2019KhanspersModified description
103637view23:03, 22 March 2019AlexanderPicofixed xref datasource
101933view12:40, 18 November 2018EgonwRemoved whitespace in PubMed identifiers.
96312view09:02, 8 March 2018Mkutmonremove outdated pathway attributes
96257view16:14, 2 March 2018EgonwOntology Term : 'platelet-derived growth factor signaling pathway' added !
95977view15:52, 11 February 2018EgonwThese interactions are not mim-conversions.
82681view13:07, 22 October 2015EgonwReplace CAS numbers of CaCl2 with ChEBI identifiers for the actual metabolites.
80006view12:18, 30 April 2015Zariannotated and updated Id for ERK1/2 (MAPK3/MAPK1), H-Ras-1 (Ras) , MAP2K4 (JNKK1)
78551view10:30, 7 January 2015MaintBotadded missing graphIds
76331view08:11, 2 July 2014MkutmonChanged database annotations from "Ensembl Human" to "Ensembl"
72247view21:52, 29 October 2013Khanspersremoved GeneOntology xrefs from data nodes
72152view11:00, 25 October 2013EgonwAdded a ChEBI ID for 'phospholipid'.
72031view13:04, 24 October 2013Mkutmonfixed unconnected lines
71715view20:08, 17 October 2013MaintBotUpdated data sources
70400view23:27, 28 July 2013AmanzoWork in progress
70399view23:24, 28 July 2013AmanzoWork in progress
70398view23:17, 28 July 2013AmanzoPeriodical save, work in progress
70397view22:47, 28 July 2013AmanzoPeriodical save, work in progress
70396view22:37, 28 July 2013AmanzoPeriodical save, work in progress
70395view22:27, 28 July 2013AmanzoPeriodical save, work in progress
70394view22:17, 28 July 2013AmanzoPeriodical save, work in progress
70393view22:07, 28 July 2013AmanzoPeriodical save, work in progress
70294view17:24, 16 July 2013AmanzoReferences added
70293view17:18, 16 July 2013AmanzoPeriodical save, work in progress
70292view17:05, 16 July 2013AmanzoOntology Term : 'cancer' added !
70291view17:05, 16 July 2013AmanzoOntology Term : 'Jak-Stat signaling pathway' added !

External references

DataNodes

View all...
NameTypeDatabase referenceComment

Ca

c h a n n e

l		Protein

Na+/H+

e x c h a n g e

r		Protein
ARFIP2ProteinP53365 (Uniprot-TrEMBL) Synonym: Por1
Actin,

stress fibers

and adhesion		PathwayWP306 (WikiPathways)
Akt pathwayPathway
Arachidonic acidMetaboliteHMDB0001043 (HMDB)
CDC42ProteinP60953 (Uniprot-TrEMBL)
COX2ProteinP00403 (Uniprot-TrEMBL)
Ca²⁺MetaboliteCHEBI:29108 (ChEBI)
Cell migrationPathway
Cell proliferationPathway
DAGMetaboliteLMGL02010000 (LIPID MAPS)
DegradationPathway
ELK1GeneProductP19419 (Uniprot-TrEMBL)
FOSGeneProductP01100 (Uniprot-TrEMBL) Synonym: c-Fos
Filopodia formationPathway
GRB2ProteinP62993 (Uniprot-TrEMBL)
HRASGeneProduct3265 (Entrez Gene) Synonyms: H-Ras-1, Ras
H⁺MetaboliteCHEBI:15378 (ChEBI)
IKKProteinO15111 (Uniprot-TrEMBL)
IP3MetaboliteCHEBI:16595 (ChEBI)
JAK1ProteinP23458 (Uniprot-TrEMBL)
JUNGeneProductP05412 (Uniprot-TrEMBL) Synonyms: AP-1, c-Jun
Lamellipodia formationPathway
MAP2K1GeneProductQ02750 (Uniprot-TrEMBL) Originally: MP2K1 (MEK 1)
MAP2K4GeneProduct6416 (Entrez Gene) Synonym: JNKK1
MAP3K1GeneProductQ13233 (Uniprot-TrEMBL) Synonym: MEKK1
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProductP45983 (Uniprot-TrEMBL) Synonym: JNK1
NFKB1GeneProduct4790 (Entrez Gene)
NFKB1GeneProduct4790 (KEGG Genes)
NFKBIAGeneProductP25963 (Uniprot-TrEMBL) Synonym: IkB alpha
NaMetaboliteCHEBI:29101 (ChEBI)
P

D G F

A		GeneProduct5154 (Entrez Gene)
PAK1ProteinQ13153 (Uniprot-TrEMBL)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRBGeneProductENSG00000113721 (Ensembl)
PGI2MetaboliteHMDB0001335 (HMDB)
PI3KProteinP27986 (Uniprot-TrEMBL)
PIP2[4',5']MetaboliteLMGP08010003 (LIPID MAPS)
PLA2G4AGeneProductENSG00000116711 (Ensembl) Synonym: cPLA2
PLCG1GeneProductENSG00000124181 (Ensembl)
PTN11GeneProductQ06124 (Uniprot-TrEMBL) Synonym: SH-PTP2
Phospholipid (containing arachidonic acid)MetaboliteCHEBI:16247 (ChEBI)
RAC1ProteinP63000 (Uniprot-TrEMBL)
RAF1ProteinP04049 (Uniprot-TrEMBL)
RASA1GeneProductENSG00000145715 (Ensembl) Synonym: GAP
RHOAProteinP61586 (Uniprot-TrEMBL)
SHC1ProteinP29353 (Uniprot-TrEMBL)
SOS1ProteinQ07889 (Uniprot-TrEMBL)
SRCProteinP12931 (Uniprot-TrEMBL) Synonym: c-Src
SRFGeneProductP11831 (Uniprot-TrEMBL)
STAT1ProteinP42224 (Uniprot-TrEMBL)
STAT3ProteinP40763 (Uniprot-TrEMBL)
TIAM1ProteinQ13009 (Uniprot-TrEMBL)
VAV1ProteinP15498 (Uniprot-TrEMBL)
VAV2ProteinP52735 (Uniprot-TrEMBL)
WASLProteinO00401 (Uniprot-TrEMBL)
[Ca²⁺+]iMetaboliteCHEBI:29108 (ChEBI)
cAMPMetaboliteHMDB0000058 (HMDB)

Annotated Interactions

No annotated interactions

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