Colchicine metabolic pathway (Homo sapiens)

Description

P450-mediated biotransformation pathway of colchicine with the CYP3A4, while colchicine inhibits the expression of this enzyme.

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Tateishi T, Soucek P, Caraco Y, Guengerich FP, Wood AJ; ''Colchicine biotransformation by human liver microsomes. Identification of CYP3A4 as the major isoform responsible for colchicine demethylation.''; Biochem Pharmacol, 1997 PubMed Europe PMC Scholia
Dvorak Z, Modriansky M, Pichard-Garcia L, Balaguer P, Vilarem MJ, Ulrichová J, Maurel P, Pascussi JM; ''Colchicine down-regulates cytochrome P450 2B6, 2C8, 2C9, and 3A4 in human hepatocytes by affecting their glucocorticoid receptor-mediated regulation.''; Mol Pharmacol, 2003 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
117685	view	12:08, 22 May 2021	Eweitz	Modified title
92288	view	12:39, 19 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
74479	view	07:42, 25 April 2014	Egonw	Fixed the Uniprot ID.
71707	view	19:59, 17 October 2013	MaintBot	Updated data sources
70549	view	22:27, 10 August 2013	Egonw	Modified description
70548	view	22:26, 10 August 2013	Egonw	Cholchicine decreases the expression of the CYP that metabolises it.
70542	view	12:31, 10 August 2013	Egonw	Indicated the source of the two current conversions.
70518	view	13:08, 9 August 2013	Egonw	Added a related paper, explaining a loop.
70517	view	13:07, 9 August 2013	Egonw	Simplified the diagram.
70513	view	12:41, 9 August 2013	Egonw	Modified description
70512	view	12:40, 9 August 2013	Egonw	Ontology Term : 'phase I biotransformation pathway via cytochrome P450' added !
70511	view	12:38, 9 August 2013	Egonw	Added the ChemSpider IDs for 2DMC and 3DMC.
70510	view	12:35, 9 August 2013	Egonw	New pathway

Name	Type	Database reference
2DMC	Metabolite	22210 (Chemspider)
3DMC	Metabolite	264748 (Chemspider)
CYP3A4	Protein	P08684 (Uniprot-TrEMBL)
Colchicine	Metabolite	5933 (Chemspider)

No annotated interactions