Methapyrilene metabolic pathway (Rattus norvegicus)

Description

No description

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Graham EE, Walsh RJ, Hirst CM, Maggs JL, Martin S, Wild MJ, Wilson ID, Harding JR, Kenna JG, Peter RM, Williams DP, Park BK; ''Identification of the thiophene ring of methapyrilene as a novel bioactivation-dependent hepatic toxicophore.''; J Pharmacol Exp Ther, 2008 PubMed Europe PMC Scholia
Ratra GS, Cottrell S, Powell CJ; ''Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene.''; Toxicol Sci, 1998 PubMed Europe PMC Scholia
Craig A, Sidaway J, Holmes E, Orton T, Jackson D, Rowlinson R, Nickson J, Tonge R, Wilson I, Nicholson J; ''Systems toxicology: integrated genomic, proteomic and metabonomic analysis of methapyrilene induced hepatotoxicity in the rat.''; J Proteome Res, 2006 PubMed Europe PMC Scholia
Uehara T, Kiyosawa N, Hirode M, Omura K, Shimizu T, Ono A, Mizukawa Y, Miyagishima T, Nagao T, Urushidani T; ''Gene expression profiling of methapyrilene-induced hepatotoxicity in rat.''; J Toxicol Sci, 2008 PubMed Europe PMC Scholia
Mercer AE, Regan SL, Hirst CM, Graham EE, Antoine DJ, Benson CA, Williams DP, Foster J, Kenna JG, Park BK; ''Functional and toxicological consequences of metabolic bioactivation of methapyrilene via thiophene S-oxidation: Induction of cell defence, apoptosis and hepatic necrosis.''; Toxicol Appl Pharmacol, 2009 PubMed Europe PMC Scholia

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Revision	Action	Time	User	Comment
116990	view	10:48, 16 May 2021	Eweitz	Modified title
92292	view	12:42, 19 May 2017	Egonw	Ontology Term : 'xenobiotic metabolic pathway' added !
77786	view	08:49, 18 October 2014	Egonw	A few more pointers.
77785	view	08:25, 18 October 2014	Egonw	Extended the pathway. Haven't found specific CYP reactions yet.
70608	view	11:11, 16 August 2013	Egonw	Widened the box.
70606	view	09:53, 16 August 2013	Egonw
70605	view	09:47, 16 August 2013	Egonw
70600	view	09:26, 16 August 2013	Egonw	Added two more metabolite structures.
70595	view	20:08, 15 August 2013	Egonw
70587	view	15:19, 15 August 2013	Egonw	Ontology Term : 'cellular detoxification pathway' added !
70586	view	15:17, 15 August 2013	Egonw	Added a first conversion and a paper discussing the metabolism.
70585	view	15:08, 15 August 2013	Egonw	New pathway

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Name	Type	Database reference	Comment
CYPs	Protein
GSH	Protein
Hepatotoxicity	Pathway
MP-Noxide	Metabolite	138399 (Chemspider)
Methapyrilene	Metabolite	3956 (Chemspider)
Periportal Liver Necrosis	Pathway
demethylated methapyrilene	Metabolite	157251 (PubChem-compound)
methapyrilene-S-oxide glutathion conjugate	Metabolite
methapyrilene-S-oxide	Metabolite	29303354 (Chemspider)	Structure has been submitted to PubChem.

No annotated interactions