RTK/Ras/MAPK - LET-23, EGL-15 independent (Caenorhabditis elegans)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Positive and negative regulators and targets of various RTK/Ras/MAPK signaling pathways in C. elegans.KSR-2LET-60/RasLIN-45/RafMEK-2/MekMPK-1/ErkSOS-1/GEFGTP????ARK-1CDF-1CLR-1CNK-1DAB-1DAF-2DPY-22DPY-23EFL-1EGL-5EGL-15EGL-17EGL-18EGL-19EGL-30ELT-6EOR-1EOR-2GAP-1GAP-2GPA-5KSR-1LET-23LET-92LET-756LIN-1LIN-2LIN-3LIN-7LIN-10LIN-12LIN-25LIN-31LIN-35LIN-39LIP-1LRP-1LRP-2LST-1LST-2LST-3LST-4PAR-1PTP-2ROM-1SEM-4SEM-5SLI-1SOC-1SOC-2SRA-13SUR-2SUR-5SUR-6SUR-7UNC-101VAB-1??Name: RTK/Ras/MAPK - LET-23, EGL-15 independentOrganism: Caenorhabditis elegans


Description

This pathway represents the core elements of Receptor Tyrosine Kinase (RTK)/Ras GTPase/MAP kinase (MAPK) pathways. Many developmental events in C. elegans require this signaling pathway with different RTK's providing activation of the pathway in specific cell-types and under different regulatory controls. Depending on the process, this signaling pathway may interact with the Wnt, Notch, or other pathways during development.

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Quality Tags

Image:Curated.pngApproved version
Image:Wormbase.pngCommunity: WormBase
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : cancer pathway
Disease : cancer
 

Bibliography

  1. Sundaram MV; ''RTK/Ras/MAPK signaling''; WormBook, 2006 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135386
Approved
view12:04, 3 September 2024EgonwRemoved the period at the end of the publication title
135367view05:28, 2 September 2024EgonwConverted to use Ensembl identifiers
78457view10:27, 7 January 2015MaintBotadded missing graphIds
71868view08:32, 19 October 2013EgonwAdded a metabolite ID.
71440view19:06, 17 October 2013MaintBotAutomated update of data sources
70988
WormBase
view23:18, 19 September 2013KyookModified description
70987view23:08, 19 September 2013KyookOntology Term : 'the extracellular signal-regulated Raf/Mek/Erk signaling pathway' added !
70986view23:07, 19 September 2013KyookOntology Term : 'Ras mediated signaling pathway' added !
70985view23:05, 19 September 2013KyookNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
?
??GeneProduct
ARK-1GeneProductWBGene00000186 (Ensembl)
CDF-1GeneProductWBGene00000393 (Ensembl)
CLR-1GeneProductWBGene00000548 (Ensembl)
CNK-1GeneProductWBGene00000564 (Ensembl)
DAB-1GeneProductWBGene00000894 (Ensembl)
DAF-2GeneProductWBGene00000898 (Ensembl)
DPY-22GeneProductWBGene00001081 (Ensembl)
DPY-23GeneProductWBGene00001082 (Ensembl)
EFL-1GeneProductWBGene00001161 (Ensembl)
EGL-15GeneProductWBGene00001184 (Ensembl)
EGL-17GeneProductWBGene00001185 (Ensembl)
EGL-18GeneProductWBGene00001186 (Ensembl)
EGL-19GeneProductWBGene00001187 (Ensembl)
EGL-30GeneProductWBGene00001196 (Ensembl)
EGL-5GeneProductWBGene00001174 (Ensembl)
ELT-6GeneProductWBGene00001253 (Ensembl)
EOR-1GeneProductWBGene00001324 (Ensembl)
EOR-2GeneProductWBGene00001325 (Ensembl)
GAP-1GeneProductWBGene00001515 (Ensembl)
GAP-2GeneProductWBGene00001516 (Ensembl)
GPA-5GeneProductWBGene00001667 (Ensembl)
GTPMetaboliteCHEBI:15996 (ChEBI)
KSR-1GeneProductWBGene00002239 (Ensembl)
KSR-2GeneProductWBGene00002240 (Ensembl)
LET-23GeneProductWBGene00002299 (Ensembl)
LET-60/RasGeneProductWBGene00002335 (Ensembl)
LET-756GeneProductWBGene00002881 (Ensembl)
LET-92GeneProductWBGene00002363 (Ensembl)
LIN-10GeneProductWBGene00002999 (Ensembl)
LIN-12GeneProductWBGene00003001 (Ensembl)
LIN-1GeneProductWBGene00002990 (Ensembl)
LIN-25GeneProductWBGene00003011 (Ensembl)
LIN-2GeneProductWBGene00002991 (Ensembl)
LIN-31GeneProductWBGene00003017 (Ensembl)
LIN-35GeneProductWBGene00003020 (Ensembl)
LIN-39GeneProductWBGene00003024 (Ensembl)
LIN-3GeneProductWBGene00002992 (Ensembl)
LIN-45/RafGeneProductWBGene00003030 (Ensembl)
LIN-7GeneProductWBGene00002996 (Ensembl)
LIP-1GeneProductWBGene00003043 (Ensembl)
LRP-1GeneProductWBGene00003071 (Ensembl)
LRP-2GeneProductWBGene00003072 (Ensembl)
LST-1GeneProductWBGene00003083 (Ensembl)
LST-2GeneProductWBGene00003084 (Ensembl)
LST-3GeneProductWBGene00003085 (Ensembl)
LST-4GeneProductWBGene00003086 (Ensembl)
MEK-2/MekGeneProductWBGene00003186 (Ensembl)
MPK-1/ErkGeneProductWBGene00003401 (Ensembl)
PAR-1GeneProductWBGene00003916 (Ensembl)
PTP-2GeneProductWBGene00004214 (Ensembl)
ROM-1GeneProductWBGene00004400 (Ensembl)
SEM-4GeneProductWBGene00004773 (Ensembl)
SEM-5GeneProductWBGene00004774 (Ensembl)
SLI-1GeneProductWBGene00004829 (Ensembl)
SOC-1GeneProductWBGene00004928 (Ensembl)
SOC-2GeneProductWBGene00004929 (Ensembl)
SOS-1/GEFGeneProductWBGene00004947 (Ensembl)
SRA-13GeneProductWBGene00005039 (Ensembl)
SUR-2GeneProductWBGene00006349 (Ensembl)
SUR-5GeneProductWBGene00006351 (Ensembl)
SUR-6GeneProductWBGene00006352 (Ensembl)
SUR-7GeneProductWBGene00006353 (Ensembl)
UNC-101GeneProductWBGene00006829 (Ensembl)
VAB-1GeneProductWBGene00006868 (Ensembl)

Annotated Interactions

No annotated interactions

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