Gastric acid production (Homo sapiens)

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14, 61G cellFoveolar cellParietal cellECL cellGastric chief cellsVIPSodium chloridePGA3GastrinPotassium chlorideBicarbonate ionsPepsinogenPepsin BHistamineGastric intrinsic factorHydrochloric acidSecretinCCKAcetylcholineMUC6Mucus and bicarbonate secretionParietal cell productionGastric histamine releaseGRP36Pepsin CPGA4PepsinogenPGA5PGCGastrin


Description

Gastric acid forms a protective buffer against pathogenic agents. It is also essential in the digestion of the food. The stomach wall is protected to the high acidity by a mucus layer and bicarbonate ions.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Sandvik AK, Waldum HL; ''CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion.''; Am J Physiol, 1991 PubMed Europe PMC Scholia
  2. Sigurdsson HH, Kirch J, Lehr CM; ''Mucus as a barrier to lipophilic drugs.''; Int J Pharm, 2013 PubMed Europe PMC Scholia
  3. Toribara NW, Roberton AM, Ho SB, Kuo WL, Gum E, Hicks JW, Gum JR Jr, Byrd JC, Siddiki B, Kim YS; ''Human gastric mucin. Identification of a unique species by expression cloning.''; J Biol Chem, 1993 PubMed Europe PMC Scholia
  4. Williams SE, Turnberg LA; ''Demonstration of a pH gradient across mucus adherent to rabbit gastric mucosa: evidence for a 'mucus-bicarbonate' barrier.''; Gut, 1981 PubMed Europe PMC Scholia
  5. Dekker J, Rossen JW, Büller HA, Einerhand AW; ''The MUC family: an obituary.''; Trends Biochem Sci, 2002 PubMed Europe PMC Scholia
  6. Allen A, Garner A; ''Mucus and bicarbonate secretion in the stomach and their possible role in mucosal protection.''; Gut, 1980 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129122view23:38, 11 March 2024EweitzRefine layering
129121view23:02, 11 March 2024EweitzStandardize case
129120view22:55, 11 March 2024EweitzEconomize layout
129113view21:36, 11 March 2024EweitzOntology Term : 'epithelial cell of stomach' added !
129112view21:36, 11 March 2024EweitzOntology Term : 'epithelial cell' added !
129108view20:49, 11 March 2024AlexanderPicomanually fixed ontology encoding
129094view04:00, 11 March 2024EweitzOntology Term : 'gastrin secreting cell' added !
129093view03:53, 11 March 2024EweitzOntology Term : 'peptic cell' added !
129092view03:52, 11 March 2024EweitzOntology Term : 'foveolar cell of stomach' added !
129091view03:51, 11 March 2024EweitzOntology Term : 'type ECL enteroendocrine cell' added !
129090view03:50, 11 March 2024EweitzUnobscure and untangle interactions, economize layout, standardize case
122782view05:30, 17 May 2022EgonwIntegrated WP2599
122781view05:27, 17 May 2022EgonwIntegrated WP2601
115458view08:06, 21 February 2021EgonwMade five pathways clickable
87520view01:54, 25 July 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
72724view15:09, 3 December 2013AndraAdded reference and MUC6
72692view11:52, 2 December 2013AndraSpecify description
72691view11:50, 2 December 2013AndraSpecify description
72689view11:43, 2 December 2013AndraAdded pathway identifier for external pathway
72687view11:34, 2 December 2013AndraAdded literature reference
72686view11:32, 2 December 2013AndraProvided identifier gor teh Gastric Gastrin release pathway
72684view11:25, 2 December 2013Andrasmall improvement
72683view11:24, 2 December 2013AndraImproved layout
72682view11:22, 2 December 2013AndraSpecify description
72679view10:59, 2 December 2013AndraUpdated pathway
72678view10:50, 2 December 2013AndraConnected unconnected line
72662view12:58, 29 November 2013AndraOntology Term : 'stomach enteroendocrine cell' added !
72661view12:56, 29 November 2013AndraOntology Term : 'parietal cell' added !
72650view11:22, 29 November 2013AndraModified description
72649view11:14, 29 November 2013AndraSpecify description
72648view11:10, 29 November 2013AndraPeriodical save, work in progress
72647view11:00, 29 November 2013AndraPeriodical save, work in progress
72646view10:50, 29 November 2013AndraPeriodical save, work in progress
72645view10:40, 29 November 2013AndraPeriodical save, work in progress
72644view10:30, 29 November 2013AndraPeriodical save, work in progress
72643view10:11, 29 November 2013AndraFirst draft
72642view10:02, 29 November 2013AndraPeriodical save, work in progress
72641view09:32, 29 November 2013AndraPeriodical save, work in progress
72640view09:21, 29 November 2013AndraPeriodical save, work in progress
72639view09:11, 29 November 2013AndraPeriodical save, work in progress
72638view09:01, 29 November 2013AndraWork in progress
72637view08:31, 29 November 2013AndraNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AcetylcholineMetabolite182 (Chemspider)
Bicarbonate ionsMetabolite749 (Chemspider)
CCKGeneProduct885 (Entrez Gene)
GRPGeneProduct2922 (Entrez Gene)
Gastric histamine releasePathwayWP2598 (WikiPathways)
Gastric intrinsic factorGeneProductP27352 (Uniprot-TrEMBL)
GastrinGeneProductP01350 (Uniprot-TrEMBL)
Histamine Metabolite753 (Chemspider)
Hydrochloric acidMetabolite307 (Chemspider)
MUC6GeneProduct4588 (Entrez Gene)
Mucus and bicarbonate secretionPathwayWP2600 (WikiPathways)
PGA3GeneProduct643834 (Entrez Gene)
PGA4GeneProduct643847 (Entrez Gene)
PGA5GeneProduct5222 (Entrez Gene)
PGCGeneProduct5225 (Entrez Gene)
Parietal cell production PathwayWP2597 (WikiPathways)
Pepsin BGeneProduct3.4.23.2 (Enzyme Nomenclature)
Pepsin CGeneProduct3.4.23.3 (Enzyme Nomenclature)
PepsinogenGeneProductO95576 (Uniprot-TrEMBL)
Potassium chlorideMetabolite4707 (Chemspider)
SecretinGeneProduct6343 (Entrez Gene)
Sodium chlorideMetabolite5044 (Chemspider)
VIPGeneProduct7432 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2596"
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