Nanoparticle-mediated activation of receptor signaling (Homo sapiens)

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1Receptor-mediated NP uptakeNP-induced extracellular ROS productionAutocrine loopIntegrinAmphiregulinCollagenApoptosisEGFRHRASFibronectinαROSNRASKRASRAFMAP2K1MAP2K2MAPK1JNK1JNK2JNK3MAPK12MAPK13MAPK14MAPK11βTalinPaxillinSrcFAKSosGrbPI3KAKTProliferationInflammationMigrationAngiogenesisDifferentiationROSEndocytosis of NP


Nanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as proliferation, apoptosis, differentiation, and migration. In lung epithelial cells, NPs interact with both EGFR and integrins, leading to cell proliferation via activation of PI3K and AKT. NPs were shown to activate the EGFR, leading in parallel to apoptosis and proliferation, and oncogenic Ras mutations might influence these effects. Interestingly, while integrin-mediated activation of ERK was instrumental for proliferation, apoptosis was mediated via activation of JNK. In addition, NPs (PM2.5) are able to bind the EGFR to activate the MAPK signaling cascade. Activation of ERK leads to the expression and secretion of the epidermal growth factor amphiregulin, thus forming an autocrine loop, which might be instrumental for sustained inflammatory responses. Nanoparticles are depicted as red circles.

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  1. Rauch J, Kolch W, Laurent S, Mahmoudi M; ''Big signals from small particles: regulation of cell signaling pathways by nanoparticles.''; Chem Rev, 2013 PubMed Europe PMC Scholia


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123429view06:39, 26 July 2022EgonwTyped six data nodes
110709view14:36, 28 May 2020LaurentAdded missing DataNode type - changed IDs to WikiPathways IDs
106660view21:19, 12 September 2019KhanspersModified description
105661view05:17, 10 August 2019KhanspersModified description
102132view09:12, 2 December 2018EgonwReplaced Wikipedia with Wikidata identifiers.
95473view08:43, 16 December 2017EgonwOh, there were two nodes :(
95472view08:42, 16 December 2017EgonwReplace a Wikipedia ID with the matching Wikidata ID (with more mappings).
92317view08:50, 20 May 2017EgonwOntology Term : 'nanomaterial response pathway' added !
87898view12:53, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
74251view08:45, 11 April 2014ElisaUsing label type for text elements
74250view08:40, 11 April 2014ElisaUsing label type for text elements
74187view11:00, 3 April 2014Bart SmeetsModified title
74186view11:00, 3 April 2014Bart SmeetsModified description
74185view10:56, 3 April 2014Bart SmeetsModified description
74184view10:55, 3 April 2014Bart SmeetsModified description
74183view10:55, 3 April 2014Bart SmeetsNew pathway

External references


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NameTypeDatabase referenceComment
AKTProteinQ9Y243 (Uniprot-TrEMBL)
AmphiregulinProteinP15514 (Uniprot-TrEMBL)
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
CollagenProteinP02452 (Uniprot-TrEMBL)
DifferentiationPathwayQ210861 (Wikidata)
EGFRProteinP00533 (Uniprot-TrEMBL)
FAKProteinQ05397 (Uniprot-TrEMBL)
FibronectinProteinP02751 (Uniprot-TrEMBL)
GrbProteinP62993 (Uniprot-TrEMBL)
HRASProteinP01112 (Uniprot-TrEMBL)
InflammationPathwayQ101991 (Wikidata)
JNK1ProteinP45983 (Uniprot-TrEMBL)
JNK2ProteinP45984 (Uniprot-TrEMBL)
JNK3ProteinP53779 (Uniprot-TrEMBL)
KRASProteinP01116 (Uniprot-TrEMBL)
MAP2K1ProteinQ02750 (Uniprot-TrEMBL)
MAP2K2ProteinP36507 (Uniprot-TrEMBL)
MAPK11ProteinQ15759 (Uniprot-TrEMBL)
MAPK12ProteinP53778 (Uniprot-TrEMBL)
MAPK13ProteinO15264 (Uniprot-TrEMBL)
MAPK14 ProteinQ16539 (Uniprot-TrEMBL)
MAPK1ProteinP28482 (Uniprot-TrEMBL)
MigrationPathwayQ189092 (Wikidata)
NRASProteinP01111 (Uniprot-TrEMBL)
PI3KProteinO00329 (Uniprot-TrEMBL)
PaxillinProteinP49023 (Uniprot-TrEMBL)
ProliferationPathwayQ189159 (Wikidata)
RAFProteinP04049 (Uniprot-TrEMBL)
ROSMetaboliteQ424361 (Wikidata)
SosProteinQ07889 (Uniprot-TrEMBL)
SrcProteinP12931 (Uniprot-TrEMBL)
TalinProteinQ9Y490 (Uniprot-TrEMBL)
αProteinP56199 (Uniprot-TrEMBL)
βProteinP05556 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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