Lidocaine metabolism (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none 2,6-xylidine3-hydroxymonoethylglycinexylidideglycinexylidideLidocaine2-amino-3-methylbenzoatemonoethylglycinexylidideCYP3A4CYP1A23-hydroxylidocaine4-hydroxy-2,6-dimethylanilineCYP1A2CYP3A4Name: Lidocaine metabolismOrganism: Homo sapiens


Description

Lidocaine is primarily metabolized by CYP1A2 but minor involvement of CYP3A4 is observed too. Based on [KEGG](http://www.genome.jp/kegg-bin/show_pathway?hsa00982).

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

Bibliography

  1. Isohanni MH, Neuvonen PJ, Olkkola KT; ''Effect of fluvoxamine and erythromycin on the pharmacokinetics of oral lidocaine.''; Basic Clin Pharmacol Toxicol, 2006 PubMed Europe PMC Scholia
  2. Wang JS, Backman JT, Wen X, Taavitsainen P, Neuvonen PJ, Kivistö KT; ''Fluvoxamine is a more potent inhibitor of lidocaine metabolism than ketoconazole and erythromycin in vitro.''; Pharmacol Toxicol, 1999 PubMed Europe PMC Scholia
  3. Orlando R, Piccoli P, De Martin S, Padrini R, Floreani M, Palatini P; ''Cytochrome P450 1A2 is a major determinant of lidocaine metabolism in vivo: effects of liver function.''; Clin Pharmacol Ther, 2004 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137745
Approved
view17:54, 7 March 2025KhanspersModified description
106722view13:16, 17 September 2019MaintBotHMDB identifier normalization
94915view00:13, 13 October 2017Khanspersmoved link to KEGG
94737view15:03, 5 October 2017EgonwAdded a missing mim-type.
92384view18:19, 31 May 2017EgonwOntology Term : 'xenobiotic metabolic pathway' added !
74430view15:48, 18 April 2014EgonwAdded a third reference.
74429view15:47, 18 April 2014EgonwModified description
74428view15:43, 18 April 2014EgonwAdded two literature references.
74427view15:36, 18 April 2014EgonwOntology Term : 'phase I biotransformation pathway via cytochrome P450' added !
74424view15:33, 18 April 2014EgonwRemoved a redundant (empty) comment.
74423view15:32, 18 April 2014EgonwNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
2,6-xylidineMetaboliteCHEBI:28738 (ChEBI)
2-amino-3-methylbenzoateMetabolite4161142 (PubChem-compound)
3-hydroxylidocaineMetabolite161824 (PubChem-compound)
3-hydroxymonoethyl glycinexylidideMetaboliteC16572 (KEGG Compound)
4-hydroxy- 2,6-dimethylanilineMetaboliteCHEBI:55545 (ChEBI)
CYP1A2GeneProductENSG00000140505 (Ensembl)
CYP3A4GeneProductENSG00000160868 (Ensembl)
LidocaineMetaboliteHMDB0014426 (HMDB)
glycinexylidideMetaboliteCHEBI:357241 (ChEBI)
monoethyl glycinexylidideMetabolite24415 (PubChem-compound)

Annotated Interactions

No annotated interactions

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