ATF6 (ATF6-alpha) activates chaperone genes (Homo sapiens)

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Bibliography

1. Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K.; ''ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response.''; PubMed Europe PMC Scholia
2. Maki RG, Old LJ, Srivastava PK.; ''Human homologue of murine tumor rejection antigen gp96: 5'-regulatory and coding regions and relationship to stress-induced proteins.''; PubMed Europe PMC Scholia
3. Yoshida H, Haze K, Yanagi H, Yura T, Mori K.; ''Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors.''; PubMed Europe PMC Scholia
4. Thuerauf DJ, Morrison L, Glembotski CC.; ''Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.''; PubMed Europe PMC Scholia
5. Wang Y, Shen J, Arenzana N, Tirasophon W, Kaufman RJ, Prywes R.; ''Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.''; PubMed Europe PMC Scholia
6. Li M, Baumeister P, Roy B, Phan T, Foti D, Luo S, Lee AS.; ''ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1.''; PubMed Europe PMC Scholia
7. Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S, Yoshida K.; ''Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress.''; PubMed Europe PMC Scholia
8. Fox RM, Andrew DJ.; ''Transcriptional regulation of secretory capacity by bZip transcription factors.''; PubMed Europe PMC Scholia
9. Okada T, Yoshida H, Akazawa R, Negishi M, Mori K.; ''Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response.''; PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
ATF4	Protein	P18848 (Uniprot-TrEMBL)
ATF6(1-380)	Protein	P18850 (Uniprot-TrEMBL)
CALR gene	GeneProduct	ENSG00000179218 (Ensembl)
CALR	Protein	P27797 (Uniprot-TrEMBL)
DDIT3 gene	GeneProduct	ENSG00000175197 (Ensembl)
DDIT3	Protein	P35638 (Uniprot-TrEMBL)
HSP90B1 gene	GeneProduct	ENSG00000166598 (Ensembl)
HSP90B1	Protein	P14625 (Uniprot-TrEMBL)
HSPA5 gene	GeneProduct	ENSG00000044574 (Ensembl)
HSPA5	Protein	P11021 (Uniprot-TrEMBL)
NF-Y	Complex	R-HSA-381204 (Reactome)	NF-Y is a ubiquitous heterotrimeric transcription factor comprising subunits NF-Y A, NF-Y B, and NF-Y C. It binds the sequence CCAAT.
NFYA	Protein	P23511 (Uniprot-TrEMBL)
NFYB	Protein	P25208 (Uniprot-TrEMBL)
NFYC	Protein	Q13952 (Uniprot-TrEMBL)
XBP1 gene	GeneProduct	ENSG00000100219 (Ensembl)
XBP1-2	Protein	P17861-2 (Uniprot-TrEMBL)

Annotated Interactions

Source	Target	Type	Database reference	Comment
ATF4		Arrow	R-HSA-1791107 (Reactome)
ATF4		Arrow	R-HSA-1791150 (Reactome)
ATF6(1-380)		Arrow	R-HSA-1791082 (Reactome)
ATF6(1-380)		Arrow	R-HSA-1791107 (Reactome)
ATF6(1-380)		Arrow	R-HSA-1791121 (Reactome)
ATF6(1-380)		Arrow	R-HSA-1791150 (Reactome)
ATF6(1-380)		Arrow	R-HSA-1791163 (Reactome)
CALR gene			R-HSA-1791082 (Reactome)
	CALR	Arrow	R-HSA-1791082 (Reactome)
DDIT3 gene			R-HSA-1791107 (Reactome)
	DDIT3	Arrow	R-HSA-1791107 (Reactome)
HSP90B1 gene			R-HSA-1791163 (Reactome)
	HSP90B1	Arrow	R-HSA-1791163 (Reactome)
HSPA5 gene			R-HSA-1791150 (Reactome)
	HSPA5	Arrow	R-HSA-1791150 (Reactome)
NF-Y		Arrow	R-HSA-1791107 (Reactome)
NF-Y		Arrow	R-HSA-1791121 (Reactome)
NF-Y		Arrow	R-HSA-1791150 (Reactome)
			R-HSA-1791082 (Reactome)	The Calreticulin gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
			R-HSA-1791107 (Reactome)	The DDIT3 (CHOP) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Bartlett et al. 1992, Carlson et al. 1993, Bruhat et al. 1997, Yoshida et al. 2000, Lee et al. 2008, Sikalidis et al. 2011). In response to amino acid starvation, transcription of DDIT3 s enhanced by ATF4 and phosphorylated ATF2 (Bruhat et al. 2000, Averous et al. 2004, Bruhat et al. 2007)
			R-HSA-1791121 (Reactome)	The XBP1 gene is transcribed to yield mRNA, the mRNA is spliced to yield Xbp(s) mRNA, and the mRNA is translated to yield protein.
			R-HSA-1791150 (Reactome)	The BIP (HSPA5) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
			R-HSA-1791163 (Reactome)	The Endoplasmin (HSP90B1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein.
XBP1 gene			R-HSA-1791121 (Reactome)
	XBP1-2	Arrow	R-HSA-1791121 (Reactome)