Matrix metalloproteinases (Rattus norvegicus)

From WikiPathways

Jump to: navigation, search
ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Based on Vu & Werb (2000)Matrix metalloproteinases: effectors ofdevelopment and normal physiology.Genes Dev 14:2123-2133CollagenasesMmp1aMmp8Mmp13GelatinasesMmp2Mmp9StromelysinsMmp10Mmp3Mmp11Membrane-type MMPsMmp14Mmp15Mmp16Mmp17MMP24Mmp25OtherMmp19Mmp28Mmp27Mmp21Mmp23EnamelysinMmp20MatrilysinMmp7MetalloelastaseMmp12InhibitorsTimp2Timp3Timp4Timp1Potential Inducers of TranscriptionBsgTnfTcf20Name: Matrix metalloproteinasesLast Modified: 2/21/2013Organism: Rattus norvegicus


Description

Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily.

Collectively they are capable of degrading all kinds of extracellular matrix proteins, but also can process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands (such as the FAS ligand), and chemokine/cytokine in/activation. MMPs are also thought to play a major role on cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis and host defense.

Source: [Wikipedia](https://en.wikipedia.org/wiki/Matrix_metalloproteinase)

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP129(r20953) with a 87% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Image:NonTypical.pngAnnotated lists
Image:Curated.pngApproved version
Homology Converted

Ontology Terms

Pathway Ontology : chorismate metabolic pathway
 

Bibliography

  1. Vu TH, Werb Z; ''Matrix metalloproteinases: effectors of development and normal physiology.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137001
Approved
view20:30, 26 February 2025KhanspersModified description
116992view10:51, 16 May 2021EweitzModified title
69444view19:05, 8 July 2013MaintBotUpdated to 2013 gpml schema
67452view11:03, 26 June 2013DdiglesOntology Term : 'cell-extracellular matrix signaling pathway' added !
58971view18:45, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41770view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
35330view08:32, 12 February 2010ThomasModified description
35328view08:31, 12 February 2010Thomasmoved reference from comments to bibliography
34765view00:41, 14 January 2010KhanspersUpdated xrefs
34138view19:32, 9 December 2009MaintBotAutomatic update of empty xrefs
32382view16:56, 15 August 2009MaintBotFixed text labels
32025view13:24, 14 August 2009MaintBotFixed group labels
31420view20:57, 13 August 2009MaintBotFixed text labels
31001view01:00, 30 July 2009MaintBotConverted from Homo sapiens
21265view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Matrix Metalloproteinases]] moved to [[Pathway:WP278]]: Moved to stable identifier
8258view13:46, 7 January 2008MaintBot[[Pathway:Rat:Matrix Metalloproteinases]] moved to [[Pathway:Rattus norvegicus:Matrix Metalloproteinases]]: Renaming species
7749view16:15, 18 December 2007MaintBotfixed category names
7430view12:42, 4 November 2007MaintBotAdded categories to GPML
19510view22:20, 22 May 2007M.Ramirezgpml file for [[Rat:Matrix_Metalloproteinases]]
6575view22:20, 22 May 2007Kdahlquistgpml file for [[Rat:Matrix_Metalloproteinases]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
BsgGeneProduct25246 (Entrez Gene)
MMP24GeneProduct83513 (Entrez Gene)
Mmp10GeneProduct117061 (Entrez Gene)
Mmp11GeneProduct25481 (Entrez Gene)
Mmp12GeneProduct117033 (Entrez Gene)
Mmp13GeneProduct171052 (Entrez Gene)
Mmp14GeneProduct81707 (Entrez Gene)
Mmp15GeneProduct291848 (Entrez Gene)
Mmp16GeneProduct65205 (Entrez Gene)
Mmp17GeneProduct288626 (Entrez Gene)
Mmp19GeneProduct304608 (Entrez Gene)
Mmp1aGeneProduct300339 (Entrez Gene)
Mmp20GeneProduct300341 (Entrez Gene)
Mmp21GeneProduct293573 (Entrez Gene)
Mmp23GeneProduct94339 (Entrez Gene)
Mmp25GeneProductENSRNOG00000029621 (Ensembl)
Mmp27GeneProduct300340 (Entrez Gene)
Mmp2GeneProduct81686 (Entrez Gene)
Mmp28GeneProduct303384 (Entrez Gene)
Mmp3GeneProduct171045 (Entrez Gene)
Mmp7GeneProduct25335 (Entrez Gene)
Mmp8GeneProduct63849 (Entrez Gene)
Mmp9GeneProduct81687 (Entrez Gene)
Tcf20GeneProduct366964 (Entrez Gene)
Timp1GeneProduct116510 (Entrez Gene)
Timp2GeneProduct29543 (Entrez Gene)
Timp3GeneProduct25358 (Entrez Gene)
Timp4GeneProduct680130 (Entrez Gene)
TnfGeneProduct24835 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools