Liver X receptor pathway (Homo sapiens)

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5Drug and steroid metabolismOtherTranscription factorsMulti-drug resistanceTranscriptionNR1H310LXR ligandNR1H3LigandGenesTATA boxNR1H3LigandLXRERXRA26, 46RXRA26, 46ABCG8CYP3A410ABCG54110CYP2B6CYP7A141SREBF141FASN41LXR target genes41SCD


Description

The liver X receptor (LXR) is a nuclear receptor involved in the regulation of liver-specific processes, such as cholesterol, fatty acid and glucose homeostasis.


Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

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  15. Marchand A, Tomkiewicz C, Marchandeau JP, Boitier E, Barouki R, Garlatti M; ''2,3,7,8-Tetrachlorodibenzo-p-dioxin induces insulin-like growth factor binding protein-1 gene expression and counteracts the negative effect of insulin.''; Mol Pharmacol, 2005 PubMed Europe PMC Scholia
  16. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  17. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  18. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
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  22. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
  23. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  24. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
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  26. Xu RX, Lambert MH, Wisely BB, Warren EN, Weinert EE, Waitt GM, Williams JD, Collins JL, Moore LB, Willson TM, Moore JT; ''A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer.''; Mol Cell, 2004 PubMed Europe PMC Scholia
  27. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  28. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  29. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
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  31. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  32. Li AC, Glass CK; ''PPAR- and LXR-dependent pathways controlling lipid metabolism and the development of atherosclerosis.''; J Lipid Res, 2004 PubMed Europe PMC Scholia
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  46. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  47. Tachibana K, Kobayashi Y, Tanaka T, Tagami M, Sugiyama A, Katayama T, Ueda C, Yamasaki D, Ishimoto K, Sumitomo M, Uchiyama Y, Kohro T, Sakai J, Hamakubo T, Kodama T, Doi T; ''''; , PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116465view10:06, 7 May 2021EweitzModified title
106631view20:55, 12 September 2019KhanspersModified description
105637view05:06, 10 August 2019KhanspersModified description
94790view23:00, 5 October 2017AlexanderPicoConverted lines
94780view22:20, 5 October 2017AlexanderPicoConverted lines and reconnected interactions
88692view15:56, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
82709view09:24, 23 October 2015EgonwMore specific ChEBI identifier.
79886view13:20, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 15581595)
79885view12:40, 23 April 2015Mkutmonremoved redundant publication xref (pubmed: 15581595)
79599view05:44, 27 March 2015EgonwFixed a bunch of PubMed references (character encodings, messed up Biopax/XML).
79598view05:36, 27 March 2015EgonwProper ChEBI identifier ("ligand" is the chemical term in ChEBI).
79553view12:22, 25 March 2015FehrhartUpdate of GenIDs and comments
79542view15:07, 24 March 2015RiannefijtenModified description
79541view15:06, 24 March 2015Riannefijtenfixed unconnected lines, added reference, changed pathway nodes to labels
79484view13:05, 23 March 2015EgonwAnnotated "ligand" with its ChEBI identifier.
78513view10:29, 7 January 2015MaintBotadded missing graphIds
78254view22:06, 17 December 2014KhanspersModified title
78214view15:03, 14 December 2014MaintBotModified title
78213view14:58, 14 December 2014EgonwChanged GPML schema.
78087view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCG5GeneProduct64240 (Entrez Gene) ATP-binding cassette, sub-family G (WHITE), member 5
ABCG8GeneProduct64241 (Entrez Gene) ATP-binding cassette, sub-family G (WHITE), member 8
CYP2B6GeneProduct1555 (Entrez Gene) cytochrome P450, family 2, subfamily B, polypeptide 6
CYP3A4GeneProduct1576 (Entrez Gene) cytochrome P450, family 3, subfamily A, polypeptide 4
CYP7A1GeneProduct1581 (Entrez Gene) cytochrome P450, family 7, subfamily A, polypeptide 1 , is not affected in human
FASNGeneProduct2194 (Entrez Gene) fatty acid synthase
LXR ligandMetaboliteCHEBI:86029 (ChEBI) T3
LigandMetaboliteCHEBI:86029 (ChEBI)
NR1H3GeneProduct10062 (Entrez Gene) nuclear receptor subfamily 1, group H, member 3
RXRAGeneProduct6256 (Entrez Gene) retinoid X receptor, alpha
SCDGeneProduct6319 (Entrez Gene)
SREBF1GeneProduct6720 (Entrez Gene) sterol regulatory element binding transcription factor 1

Annotated Interactions

No annotated interactions

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