Vitamin D receptor pathway (Homo sapiens)

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56, 10, 13, 14, 18...transcriptionBCL6LPGAT1TREM1STSLRRC25ITGAMGenesTATA boxVDREVDRLigandRXRAVDRVDR ligandRXRAVDRLigandVDR target genes35, 54IRF4HLA-DRB1CLEC16AHSD17B2CDKAL1Col13A1TNFAIP3FGF23CYP24A1CST6DEFB4ACD40PRKCQIRF5IL1RL1HLA-DQA1CLPTM1LCAMPTNFSF4STAMHIF1ACTLA4CLMNMXD1PTHTRPV5TRPV6CYP27B1PTGER4TNFSF11PRDM1RASGRP1SLC34A2CYP7A158CYP2B6CYP2C92121THBDKLCASP5TRAK1LRP5DUSP10SEMA3BKLK6SULT2A1SERPINB1NRIP1CYP3A4SPP1CEACAM1PTHLHS100A2BGLAPASAP2ID4SOSTDC1BTLACD14KLF4ALOX5IL12AADGRE5SLC37A2SATB1CBSLRRC8AMYO9BBDKRB1NINJ1NRIP1CD200CD9TPM1ALPISLC2A4CYP1A1S100GATP2C2SLC8A1CALB1TGFB1STEAP4ADAMTS5TNFRSF11BHILPDAALPGCLDN2ATP2B1SULT1C2S100A9MED9LCE1FABCD1CDX2DACT2KNG1IRF8MX2NOX1TGFB2ORM2EPHB4ABC B1JUNBCYP2S1G6PDS100A8TIMP3CEBPACDC34GXYLT2CYP3A5CASP14ORM1LCE1DABCA11EFNA5TIMP2KRTAP4-1KRT13KRT71KRTAP10-4S100A4SPRR1BS100A6KRTAP10-2KRTAP5-4LCE2BKRT34KRTAP5-1KRT16KRTAP10-7KRT38KRTAP8-1SALL4CRACR2BHNF1ACRACR2ACYP2D6ID1KRTAP10-9DEFB109CKRTAP12-2DEFB132CREG2COLEC11ZNF257CST1CA9PNOCDNERDND1CDKN1ALGALS9CDKN1BIL25SFRP1ADRA1BBMP6IGSF9BADRB2MEG8NFATC2CCND1CDKN2DGADD45ACCNE1CDKN2ACDK2CDKN2BCDKN2CCCNCMYCFOXO1IGFBP1IGFBP3PPARDIGFBP5G0S2


Description

The vitamin D receptor (VDR, a.k.a. NR1I1) is a nuclear receptor that responds to binding of vitamin D and subsequently forms a dimer with RXR to induce transcription of its target genes. It mainly regulates genes cytochrome P450 genes involved in xenobiotic biotransformation. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal.

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Bibliography

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  60. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
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History

View all...
CompareRevisionActionTimeUserComment
119905view14:40, 13 September 2021Alvin kho
119904view14:38, 13 September 2021Alvin kho
119903view14:28, 13 September 2021Alvin kho
119902view14:19, 13 September 2021Alvin kho
119901view14:05, 13 September 2021Alvin kho
117854view15:20, 22 May 2021EweitzModified title
105854view23:17, 15 August 2019KhanspersModified description
94793view23:03, 5 October 2017AlexanderPicoConverted lines
94783view22:35, 5 October 2017AlexanderPicoConverted lines
86976view14:30, 15 July 2016MkutmonOntology Term : 'vitamin D signaling pathway' added !
84568view12:16, 3 March 2016Mkutmonfix literature references
84567view12:11, 3 March 2016Mkutmonfix literature references
84566view11:46, 3 March 2016Mkutmonadded missing graph ids
80091view11:56, 6 May 2015Kim de NooijerAdd literature to the VDR target genes
80090view11:32, 6 May 2015Kim de NooijerLiterature
79998view08:07, 30 April 2015Kim de NooijerAdd VDR target genes
79876view10:36, 23 April 2015Kim de NooijerAdding VDR target genes
79875view10:30, 23 April 2015Kim de NooijerAdding VDR target genes
79534view14:49, 24 March 2015RiannefijtenModified description
79533view14:46, 24 March 2015Riannefijtenadded reference, fixed unconnected lines, changed pathway nodes to labels
79493view13:35, 23 March 2015EgonwAnnotated "ligand" with the ChEBI identifier for 'agonist'.
79478view12:47, 23 March 2015FehrhartUpdate GenID and comments
79477view12:45, 23 March 2015FehrhartUpdate Gen IDs and comments
78514view10:29, 7 January 2015MaintBotadded missing graphIds
78252view22:03, 17 December 2014KhanspersModified title
78224view15:27, 14 December 2014MaintBotUpdated the GPML schema.
78219view15:08, 14 December 2014MaintBotModified title
78090view11:37, 2 December 2014RiannefijtenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABC B1GeneProduct5243 (Entrez Gene)
ABCA11GeneProduct79963 (Entrez Gene)
ABCD1GeneProduct215 (Entrez Gene)
ADAMTS5GeneProduct11096 (Entrez Gene)
ADGRE5GeneProduct976 (Entrez Gene)
ADRA1BGeneProduct147 (Entrez Gene)
ADRB2GeneProduct154 (Entrez Gene)
ALOX5GeneProduct240 (Entrez Gene)
ALPGGeneProduct251 (Entrez Gene)
ALPIGeneProduct248 (Entrez Gene)
ASAP2GeneProduct8853 (Entrez Gene)
ATP2B1GeneProduct490 (Entrez Gene)
ATP2C2GeneProduct9914 (Entrez Gene)
BCL6GeneProduct604 (Entrez Gene)
BDKRB1GeneProduct623 (Entrez Gene)
BGLAPGeneProduct632 (Entrez Gene)
BMP6GeneProduct654 (Entrez Gene)
BTLAGeneProduct151888 (Entrez Gene)
CA9GeneProduct768 (Entrez Gene)
CALB1GeneProduct12307 (Entrez Gene)
CAMPGeneProduct820 (Entrez Gene)
CASP14GeneProduct23581 (Entrez Gene)
CASP5GeneProduct838 (Entrez Gene)
CBSGeneProduct875 (Entrez Gene)
CCNCGeneProduct892 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CCNE1GeneProduct898 (Entrez Gene)
CD14GeneProduct929 (Entrez Gene)
CD200GeneProduct4345 (Entrez Gene)
CD40GeneProduct958 (Entrez Gene)
CD9GeneProduct928 (Entrez Gene)
CDC34GeneProduct997 (Entrez Gene)
CDK2GeneProduct1017 (Entrez Gene)
CDKAL1GeneProduct54901 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CDKN1BGeneProduct1027 (Entrez Gene)
CDKN2AGeneProduct1029 (Entrez Gene)
CDKN2BGeneProduct1030 (Entrez Gene)
CDKN2CGeneProduct1031 (Entrez Gene)
CDKN2DGeneProduct1032 (Entrez Gene)
CDX2GeneProduct1045 (Entrez Gene)
CEACAM1GeneProduct634 (Entrez Gene)
CEBPAGeneProduct1050 (Entrez Gene)
CLDN2GeneProduct9075 (Entrez Gene)
CLEC16AGeneProduct23274 (Entrez Gene)
CLMNGeneProduct79789 (Entrez Gene)
CLPTM1LGeneProduct81037 (Entrez Gene)
COLEC11GeneProduct78989 (Entrez Gene)
CRACR2AGeneProduct84766 (Entrez Gene)
CRACR2BGeneProduct283229 (Entrez Gene)
CREG2GeneProduct200407 (Entrez Gene)
CST1GeneProduct1469 (Entrez Gene)
CST6GeneProduct1474 (Entrez Gene)
CTLA4GeneProduct1493 (Entrez Gene)
CYP1A1GeneProduct1543 (Entrez Gene)
CYP24A1GeneProduct1591 (Entrez Gene)
CYP27B1GeneProduct1594 (Entrez Gene)
CYP2B6GeneProduct1555 (Entrez Gene) cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2C9GeneProduct1559 (Entrez Gene) cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6GeneProduct1565 (Entrez Gene)
CYP2S1GeneProduct29785 (Entrez Gene)
CYP3A4GeneProduct1576 (Entrez Gene)
CYP3A5GeneProduct1577 (Entrez Gene)
CYP7A1GeneProduct1581 (Entrez Gene) cytochrome P450, family 7, subfamily A, polypeptide 1
Col13A1GeneProduct1305 (Entrez Gene)
DACT2GeneProduct168002 (Entrez Gene)
DEFB109CGeneProduct100286963 (Entrez Gene)
DEFB132GeneProduct400830 (Entrez Gene)
DEFB4AGeneProduct1673 (Entrez Gene)
DND1GeneProduct373863 (Entrez Gene)
DNERGeneProduct92737 (Entrez Gene)
DUSP10GeneProduct11221 (Entrez Gene)
EFNA5GeneProduct1946 (Entrez Gene)
EPHB4GeneProduct2050 (Entrez Gene)
FGF23GeneProduct8074 (Entrez Gene)
FOXO1GeneProduct2308 (Entrez Gene)
G0S2GeneProduct50486 (Entrez Gene)
G6PDGeneProduct2539 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
GXYLT2GeneProduct727936 (Entrez Gene)
HIF1AGeneProduct3091 (Entrez Gene)
HILPDAGeneProduct29923 (Entrez Gene)
HLA-DQA1GeneProduct3117 (Entrez Gene)
HLA-DRB1GeneProduct3123 (Entrez Gene)
HNF1AGeneProduct6927 (Entrez Gene)
HSD17B2GeneProduct3294 (Entrez Gene)
ID1GeneProduct3397 (Entrez Gene)
ID4GeneProduct3400 (Entrez Gene)
IGFBP1GeneProduct3484 (Entrez Gene)
IGFBP3GeneProduct3486 (Entrez Gene)
IGFBP5GeneProduct3488 (Entrez Gene)
IGSF9BGeneProduct22997 (Entrez Gene)
IL12AGeneProduct3592 (Entrez Gene)
IL1RL1GeneProduct9173 (Entrez Gene)
IL25GeneProduct64806 (Entrez Gene)
IRF4GeneProduct3662 (Entrez Gene)
IRF5GeneProduct3663 (Entrez Gene)
IRF8GeneProduct3394 (Entrez Gene)
ITGAMGeneProduct3684 (Entrez Gene)
JUNBGeneProduct3726 (Entrez Gene)
KLGeneProduct9365 (Entrez Gene)
KLF4GeneProduct9314 (Entrez Gene)
KLK6GeneProduct5653 (Entrez Gene)
KNG1GeneProduct3827 (Entrez Gene)
KRT13GeneProduct3860 (Entrez Gene)
KRT16GeneProduct3868 (Entrez Gene)
KRT34GeneProduct3885 (Entrez Gene)
KRT38GeneProduct8687 (Entrez Gene)
KRT71GeneProduct112802 (Entrez Gene)
KRTAP10-2GeneProduct386679 (Entrez Gene)
KRTAP10-4GeneProduct386672 (Entrez Gene)
KRTAP10-7GeneProduct386675 (Entrez Gene)
KRTAP10-9GeneProduct386676 (Entrez Gene)
KRTAP12-2GeneProduct353323 (Entrez Gene)
KRTAP4-1GeneProduct85285 (Entrez Gene)
KRTAP5-1GeneProduct387264 (Entrez Gene)
KRTAP5-4GeneProduct387267 (Entrez Gene)
KRTAP8-1GeneProduct337879 (Entrez Gene)
LCE1DGeneProduct353134 (Entrez Gene)
LCE1FGeneProduct353137 (Entrez Gene)
LCE2BGeneProduct26239 (Entrez Gene)
LGALS9GeneProduct3965 (Entrez Gene)
LPGAT1GeneProduct9926 (Entrez Gene)
LRP5GeneProduct4041 (Entrez Gene)
LRRC25GeneProduct126364 (Entrez Gene)
LRRC8AGeneProduct56262 (Entrez Gene)
LigandMetaboliteCHEBI:48705 (ChEBI)
MED9GeneProduct55090 (Entrez Gene)
MEG8GeneProduct79104 (Entrez Gene)
MX2GeneProduct4600 (Entrez Gene)
MXD1GeneProduct4084 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
MYO9BGeneProduct4650 (Entrez Gene)
NFATC2GeneProduct4773 (Entrez Gene)
NINJ1GeneProduct4814 (Entrez Gene)
NOX1GeneProduct27035 (Entrez Gene)
NRIP1GeneProduct8204 (Entrez Gene)
ORM1GeneProduct5004 (Entrez Gene)
ORM2GeneProduct5005 (Entrez Gene)
PNOCGeneProduct5368 (Entrez Gene)
PPARDGeneProduct5467 (Entrez Gene)
PRDM1GeneProduct639 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PTGER4GeneProduct5734 (Entrez Gene)
PTHGeneProduct5741 (Entrez Gene)
PTHLHGeneProduct5744 (Entrez Gene)
RASGRP1GeneProduct10125 (Entrez Gene)
RXRAGeneProduct6256 (Entrez Gene) retinoid X receptor, alpha
S100A2GeneProduct6273 (Entrez Gene)
S100A4GeneProduct6275 (Entrez Gene)
S100A6GeneProduct6277 (Entrez Gene)
S100A8GeneProduct6279 (Entrez Gene)
S100A9GeneProduct6280 (Entrez Gene)
S100GGeneProduct795 (Entrez Gene)
SALL4GeneProduct57167 (Entrez Gene)
SATB1GeneProduct6304 (Entrez Gene)
SEMA3BGeneProduct7869 (Entrez Gene)
SERPINB1GeneProduct1992 (Entrez Gene)
SFRP1GeneProduct6422 (Entrez Gene)
SLC2A4GeneProduct6517 (Entrez Gene)
SLC34A2GeneProduct10568 (Entrez Gene)
SLC37A2GeneProduct219855 (Entrez Gene)
SLC8A1GeneProduct6546 (Entrez Gene)
SOSTDC1GeneProduct25928 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)
SPRR1BGeneProduct6699 (Entrez Gene)
STAMGeneProduct8027 (Entrez Gene)
STEAP4GeneProduct79689 (Entrez Gene)
STSGeneProduct412 (Entrez Gene)
SULT1C2GeneProduct6819 (Entrez Gene)
SULT2A1GeneProduct6822 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
THBDGeneProduct7056 (Entrez Gene)
TIMP2GeneProduct7077 (Entrez Gene)
TIMP3GeneProduct7078 (Entrez Gene)
TNFAIP3GeneProduct7128 (Entrez Gene)
TNFRSF11BGeneProduct4982 (Entrez Gene)
TNFSF11GeneProduct8600 (Entrez Gene)
TNFSF4GeneProduct7292 (Entrez Gene)
TPM1GeneProduct7168 (Entrez Gene)
TRAK1GeneProduct22906 (Entrez Gene)
TREM1GeneProduct54210 (Entrez Gene)
TRPV5GeneProduct56302 (Entrez Gene)
TRPV6GeneProduct55503 (Entrez Gene)
VDR ligandMetaboliteCHEBI:48705 (ChEBI) T3
VDRGeneProduct7421 (Entrez Gene) vitamin D (1,25- dihydroxyvitamin D3) receptor
ZNF257GeneProduct113835 (Entrez Gene)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2877"
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