Role of lipid metabolism (Caenorhabditis elegans)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Fat storageKeyInhibitsWell fed animalsATPLPD-5Unfolded protein response (UPR)LPD-6CCO-1/LPD-4LPD-3SIR-2.1/SIR2.1LPD-9MAC-1LPD-8LPD-7SBP-1CBP-1HSP-4ATGL-1PhosphorylatedAAK-2PAR-4KRI-1lips-7DAF-16CTBP-1DAF-2Proposed to inhibitProposed to stimulateStimulatesDAF-16lipl-4DAF-16 translocation to nucleusStarvationfil-1lips-7Conditional stimulationIRE-1Dauer animalsPhosphorylation ofAAK-2AAK-2RegulatesPhosphorylatesLIFESPANPositivelyinfluencesNegatively influencesName: Role of lipid metabolismOrganism: Caenorhabditis elegans


Description

"Lipases regulate life span in C. elegans. Several lipases, K04A8.5, LIPS-7, FIL-1, FIL-2, and ATGL-1, have been demonstrated to influence the lifespan of C. elegans. The

figure depicts the mechanisms by which these lipases are regulated and the pathways by which they affect longevity. Well fed animals were shown to live longer during germline stem cell (GSC) arrest. This phenotype depends on K04A8.5 lipase activity, which was suggested to be promoted by the KRI-1/DAF-16 signalling pathway. Additionally, a ctbp-1 mutant also displayed increased lifespan during well fed conditions. It was proposed that this NAD(H)-dependent corepressor, CTBP-1, acted downstream of SIR2.1 and DAF-2 but up stream of DAF-16. One of its target genes lips-7 encodes a lipase and is required for the increased life span of ctbp-1 mutants. IRE-1 and HSP-4, which are normally involved in the unfolded protein response, are required for expression of FIL-1 and FIL-2 during starvation. The two transcription regulators, SBP-1 and CBP-1, are likewise required for FIL-1 and FIL-2 induction. The a2 catalytic subunit of AMP-dependent kinase (AMPK) regulates the activity of the C. elegans paralogue of the adipose triglyceride lipase, ATGL-1, during the dauer stage. AMPK is regulated by AMP levels and by phosphorylation by human homologue of LKB1 kinase

PAR-4." Fig 1. Elle, et al., 2010. Fat storage genes identified in McKay et al., 2003.

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Quality Tags

Image:Curated.pngApproved version
Image:Wormbase.pngCommunity: WormBase
Image:Unconnected.pngFix interactions
Image:MissingXref.pngAnnotate nodes

Ontology Terms

 

Bibliography

  1. Elle IC, Olsen LC, Pultz D, Rødkaer SV, Faergeman NJ; ''Something worth dyeing for: molecular tools for the dissection of lipid metabolism in Caenorhabditis elegans.''; FEBS Lett, 2010 PubMed Europe PMC Scholia
  2. McKay RM, McKay JP, Avery L, Graff JM; ''C elegans: a model for exploring the genetics of fat storage.''; Dev Cell, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
135380
Approved
view19:36, 2 September 2024EgonwConverted to use Ensembl identifiers
118329view12:56, 27 May 2021UlasBabayigitturned arrows in legend and lip-4/7 and fil-1 transcription arrows into graphical lines
116501view10:37, 7 May 2021EweitzModified title
107083view14:17, 17 September 2019MaintBotChEBI identifier normalization
87643view08:54, 25 July 2016LindarieswijkOntology Term : 'lipid metabolic pathway' added !
79936view17:42, 27 April 2015Kyookadded WP2578 to UPR node
79874view23:52, 22 April 2015KyookModified description
79873
WormBase
view23:48, 22 April 2015KyookNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AAK-2GeneProductWBGene00020142 (Ensembl)
ATGL-1GeneProductWBGene00015484 (Ensembl)
ATPMetaboliteCHEBI:15422 (ChEBI)
CBP-1GeneProductWBGene00000366 (Ensembl)
CCO-1/LPD-4GeneProductF26E4.9 (WormBase)
CTBP-1GeneProductWBGene00006424 (Ensembl)
DAF-16

translocation

to nucleus
GeneProductWBGene00000912 (Ensembl)
DAF-16GeneProductWBGene00000912 (Ensembl)
DAF-2GeneProductWBGene00000898 (Ensembl)
HSP-4GeneProductWBGene00002008 (Ensembl)
IRE-1GeneProductWBGene00002147 (Ensembl)
KRI-1GeneProductWBGene00013955 (Ensembl)
LIFESPAN
LPD-3GeneProductWBGene00003060 (Ensembl)
LPD-5GeneProductWBGene00003061 (Ensembl)
LPD-6GeneProductWBGene00003062 (Ensembl)
LPD-7GeneProductWBGene00003063 (Ensembl)
LPD-8GeneProductWBGene00003064 (Ensembl)
LPD-9GeneProductWBGene00003065 (Ensembl)
MAC-1GeneProductWBGene00003119 (Ensembl)
PAR-4GeneProductWBGene00003919 (Ensembl)
Phosphorylated AAK-2GeneProductWBGene00020142 (Ensembl)
Phosphorylation of AAK-2GeneProductWBGene00000912 (Ensembl)
SBP-1GeneProductWBGene00004735 (Ensembl)
SIR-2.1/SIR2.1GeneProductR11A8.4 (WormBase)
Unfolded protein response (UPR)PathwayWP2578 (WikiPathways)
fil-1GeneProductWBGene00011321 (Ensembl)
lipl-4GeneProductWBGene00019376 (Ensembl)
lips-7GeneProductWBGene00015645 (Ensembl)

Annotated Interactions

No annotated interactions

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