Interactome of polycomb repressive complex 2 (PRC2) (Homo sapiens)
From WikiPathways
Description
A proposed interactome of Polycomb repressive complex 2 (PRC2), based on proteomics. PRC2 has histone methyltransferase activity and primarily trimethylates histone H3 on lysine 27, a mark of transcriptionally silent chromatin, and is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced.
Based on figure 1B in [Shen et al](https://www.ncbi.nlm.nih.gov/pubmed/20064376).
Quality Tags
Ontology Terms
Pathway Ontology : regulatory pathway
Bibliography
- Bracken CP, Wall SJ, Barré B, Panov KI, Ajuh PM, Perkins ND; ''Regulation of cyclin D1 RNA stability by SNIP1.''; Cancer Res, 2008 PubMed Europe PMC Scholia
- Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH; ''Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.''; Cell, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name ![]() | Type ![]() | Database reference ![]() | Comment ![]() |
---|---|---|---|
AEBP2 | GeneProduct | ENSG00000139154 (Ensembl) ![]() | |
BCLAF1 | GeneProduct | ENSG00000029363 (Ensembl) ![]() | |
EED | GeneProduct | ENSG00000074266 (Ensembl) ![]() | |
ELL | GeneProduct | ENSG00000105656 (Ensembl) ![]() | |
EZH1 | GeneProduct | ENSG00000108799 (Ensembl) ![]() | |
EZH2 | GeneProduct | ENSG00000106462 (Ensembl) ![]() | |
JMJ | GeneProduct | ENSG00000008083 (Ensembl) ![]() | |
MORC3 | GeneProduct | ENSG00000159256 (Ensembl) ![]() | |
MTF2 | GeneProduct | ENSG00000143033 (Ensembl) ![]() | |
RBBP4 | GeneProduct | ENSG00000162521 (Ensembl) ![]() | |
RBBP7 | GeneProduct | ENSG00000102054 (Ensembl) ![]() | |
SETX | GeneProduct | ENSG00000107290 (Ensembl) ![]() | |
STK38 | GeneProduct | ENSG00000112079 (Ensembl) ![]() | |
SUZ12 | GeneProduct | ENSG00000178691 (Ensembl) ![]() | |
THRAP3 | GeneProduct | ENSG00000054118 (Ensembl) ![]() | |
TRIM35 | GeneProduct | ENSG00000104228 (Ensembl) ![]() |
Annotated Interactions
No annotated interactions