Interactome of polycomb repressive complex 2 (PRC2) (Homo sapiens)
From WikiPathways
Description
A proposed interactome of Polycomb repressive complex 2 (PRC2), based on proteomics. PRC2 has histone methyltransferase activity and primarily trimethylates histone H3 on lysine 27, a mark of transcriptionally silent chromatin, and is required for initial targeting of genomic region (PRC Response Elements or PRE) to be silenced.
Based on figure 1B in Shen et al.
Quality Tags
Ontology Terms
Saving...Bibliography
- Bracken CP, Wall SJ, Barré B, Panov KI, Ajuh PM, Perkins ND; ''Regulation of cyclin D1 RNA stability by SNIP1.''; Cancer Res, 2008 PubMed Europe PMC Scholia
- Shen X, Kim W, Fujiwara Y, Simon MD, Liu Y, Mysliwiec MR, Yuan GC, Lee Y, Orkin SH; ''Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.''; Cell, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| AEBP2 | GeneProduct | ENSG00000139154 (Ensembl)  | |
| BCLAF1 | GeneProduct | ENSG00000029363 (Ensembl) | |
| EED | GeneProduct | ENSG00000074266 (Ensembl) | |
| ELL | GeneProduct | ENSG00000105656 (Ensembl) | |
| EZH1 | GeneProduct | ENSG00000108799 (Ensembl) | |
| EZH2 | GeneProduct | ENSG00000106462 (Ensembl) | |
| JMJ | GeneProduct | ENSG00000008083 (Ensembl) | |
| MORC3 | GeneProduct | ENSG00000159256 (Ensembl) | |
| MTF2 | GeneProduct | ENSG00000143033 (Ensembl) | |
| RBBP4 | GeneProduct | ENSG00000162521 (Ensembl) | |
| RBBP7 | GeneProduct | ENSG00000102054 (Ensembl) | |
| SETX | GeneProduct | ENSG00000107290 (Ensembl) | |
| STK38 | GeneProduct | ENSG00000112079 (Ensembl) | |
| SUZ12 | GeneProduct | ENSG00000178691 (Ensembl) | |
| THRAP3 | GeneProduct | ENSG00000054118 (Ensembl) | |
| TRIM35 | GeneProduct | ENSG00000104228 (Ensembl) |
Annotated Interactions
No annotated interactions
