Biotin biosynthesis II (Oryza sativa)

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Description

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Ontology Terms

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History

Compare	Revision	Action	Time	User	Comment
	118128	view	10:34, 25 May 2021	Eweitz	Modified title
	86999	view	14:41, 15 July 2016	Mkutmon	Ontology Term : 'biotin metabolic pathway' added !
	82002	view	14:39, 8 September 2015	Anwesha	fixing title, data source, & tagging incomplete pathways
	80497	view	14:48, 25 June 2015	Anwesha	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
	Metabolite
7,8-diaminopelargonate	Metabolite	CHEBI:2247 (ChEBI)
7-keto-8-aminopelargonate	Metabolite	CHEBI:15830 (ChEBI)
8-amino-7-oxononanoate synthase	Protein	1122039 (Reactome)	Facilitates the combination of L-alanine and pimeloyl-CoA to form 7-keto-8-aminopelargonate.
ADP	Metabolite	CHEBI:16761 (ChEBI)
ATP	Metabolite	CHEBI:15422 (ChEBI)
AdoMet	Metabolite	CHEBI:15414 (ChEBI)
Ala	Metabolite	CHEBI:16977 (ChEBI)
Btn	Metabolite	CHEBI:15956 (ChEBI)
CO2	Metabolite	CHEBI:16526 (ChEBI)
CoA-SH	Metabolite	CHEBI:15346 (ChEBI)
Pi	Metabolite	CHEBI:18367 (ChEBI)
S-adenosyl-4-methylthio-2-oxobutanoate	Metabolite	CHEBI:8944 (ChEBI)
a sulfur donor		1131485 (Reactome)
a sulfurated sulfur donor		1131438 (Reactome)
adenosylmethionine--8-amino-7-oxononanoate transaminase	Protein	1121777 (Reactome)	Facilitates the conversion of 7-keto-8-aminopelargonate to 7,8-diaminopelargonate.
an unsulfurated sulfur acceptor		1132100 (Reactome)
biotin synthase (LOC_OS08G42730.1)	Protein	Q69U93 (Uniprot-TrEMBL)	Facilitates the conversion of dethiobiotin to 9-mercaptodethiobiotin.
dethiobiotin	Metabolite	CHEBI:16691 (ChEBI)
pimeloyl-CoA	Metabolite	CHEBI:15504 (ChEBI)

Annotated Interactions

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Source	Target	Type	Database reference	Comment
			1119870 (Reactome)	7-keto-8-aminopelargonate is converted to 7,8-diaminopelargonate by adenosylmethionine--8-amino-7-oxononanoate aminotransferase.
			1120139 (Reactome)
			1120881 (Reactome)	L-alanine and pimeloyl-CoA are combined by enzymatic activity of 8-amino-7-oxononanoate synthase to form 7-keto-8-aminopelargonate.
			1121121 (Reactome)	Dethiobiotin is converted to 9-mercaptodethiobiotin by enzymatic activity of biotin synthase.
			1121531 (Reactome)	7,8-diaminopelargonate is converted to dethiobiotin by enzymatic activity of an unknown enzyme.
7,8-diaminopelargonate			1121531 (Reactome)
	7,8-diaminopelargonate	Arrow	1119870 (Reactome)
7-keto-8-aminopelargonate			1119870 (Reactome)
	7-keto-8-aminopelargonate	Arrow	1120881 (Reactome)
8-amino-7-oxononanoate synthase		mim-catalysis	1120881 (Reactome)
	ADP	Arrow	1121531 (Reactome)
ATP			1121531 (Reactome)
AdoMet			1119870 (Reactome)
Ala			1120881 (Reactome)
		Arrow	1121121 (Reactome)
	Btn	Arrow	1120139 (Reactome)
CO2			1121531 (Reactome)
	CO2	Arrow	1120881 (Reactome)
	CoA-SH	Arrow	1120881 (Reactome)
	Pi	Arrow	1121531 (Reactome)
	S-adenosyl-4-methylthio-2-oxobutanoate	Arrow	1119870 (Reactome)
a sulfur donor			1121121 (Reactome)
a sulfurated sulfur donor			1121121 (Reactome)
adenosylmethionine--8-amino-7-oxononanoate transaminase		mim-catalysis	1119870 (Reactome)
	an unsulfurated sulfur acceptor	Arrow	1121121 (Reactome)
biotin synthase (LOC_OS08G42730.1)		mim-catalysis	1120139 (Reactome)
biotin synthase (LOC_OS08G42730.1)		mim-catalysis	1121121 (Reactome)
dethiobiotin			1121121 (Reactome)
	dethiobiotin	Arrow	1121531 (Reactome)
pimeloyl-CoA			1120881 (Reactome)