Mevalonate pathway (Arabidopsis thaliana)

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This event has been computationally inferred from an event that has been demonstrated in another species.

The inference is based on Ensembl Compara orthology projection. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped ortholog or paralog are inferred to the other species. High-level events are also inferred for these events to allow for easier navigation.<p>Details of projection methods and parameters may be found <a href="/projection.html">here.</a><p> Source:Plant Reactome.</div>

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Ontology Terms

Bibliography

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History

Compare	Revision	Action	Time	User	Comment
	118203	view	11:40, 26 May 2021	Eweitz	Modified title
	90907	view	00:17, 17 December 2016	AlexanderPico	fixed interactions
	82121	view	14:44, 8 September 2015	Anwesha	fixing title, data source, & tagging incomplete pathways
	80619	view	14:53, 25 June 2015	Anwesha	New pathway

External references

DataNodes

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Name	Type	Database reference	Comment
(R)-mevalonate	Metabolite	CHEBI:25351 (ChEBI)
ACA-CoA	Metabolite	CHEBI:15345 (ChEBI)
ADP	Metabolite	CHEBI:16761 (ChEBI)
AT4G11820	Protein	AT4G11820 (TAIR)
AT5G27450	Protein	AT5G27450 (TAIR)
ATP	Metabolite	CHEBI:15422 (ChEBI)
Ac-CoA	Metabolite	CHEBI:15351 (ChEBI)
CO2	Metabolite	CHEBI:16526 (ChEBI)
CoA-SH	Metabolite	CHEBI:15346 (ChEBI)
DMAPP	Metabolite	CHEBI:16057 (ChEBI)
H2O	Metabolite	CHEBI:15377 (ChEBI)
Homologues of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (LOC_OS08G40180.1)	Protein	5400562 (Reactome)
Homologues of acetyl-CoA acetyltransferase (LOC_OS09G07830.1)	Protein	5399891 (Reactome)
Homologues of hydrolase (LOC_OS07G36190.1)	Protein	5401384 (Reactome)
Homologues of GHMP kinases ATP-binding protein (LOC_OS02G01920.1)	Protein	5399468 (Reactome)
IPPP	Metabolite	CHEBI:16584 (ChEBI)
MVA5P	Metabolite	CHEBI:17436 (ChEBI)
MVA5PP	Metabolite	CHEBI:15899 (ChEBI)
NADP+	Metabolite	CHEBI:18009 (ChEBI)
NADPH	Metabolite	CHEBI:16474 (ChEBI)
Pi	Metabolite	CHEBI:18367 (ChEBI)
bHMG-CoA	Metabolite	CHEBI:15467 (ChEBI)

Annotated Interactions

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Source	Target	Type	Database reference	Comment
(R)-mevalonate	MVA5P	Arrow	5398448 (Reactome)
ACA-CoA	bHMG-CoA	Arrow	5399831 (Reactome)
	ADP	Arrow	5398448 (Reactome)
	ADP	Arrow	5399470 (Reactome)
AT4G11820		mim-catalysis	5399831 (Reactome)
AT5G27450		mim-catalysis	5398448 (Reactome)
ATP			5398448 (Reactome)
ATP			5399470 (Reactome)
Ac-CoA			5399831 (Reactome)
Ac-CoA	ACA-CoA	Arrow	5399893 (Reactome)
	CO2	Arrow	5399470 (Reactome)
	CoA-SH	Arrow	5399831 (Reactome)
	CoA-SH	Arrow	5399893 (Reactome)
	CoA-SH	Arrow	5400564 (Reactome)
H2O			5399831 (Reactome)
Homologues of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (LOC_OS08G40180.1)		mim-catalysis	5400564 (Reactome)
Homologues of acetyl-CoA acetyltransferase (LOC_OS09G07830.1)		mim-catalysis	5399893 (Reactome)
Homologues of hydrolase (LOC_OS07G36190.1)	DMAPP	mim-catalysis	5401386 (Reactome)
Homologues of GHMP kinases ATP-binding protein (LOC_OS02G01920.1)		mim-catalysis	5399470 (Reactome)
IPPP	DMAPP	Arrow	5401386 (Reactome)
MVA5PP	IPPP	Arrow	5399470 (Reactome)
	NADP+	Arrow	5400564 (Reactome)
NADPH			5400564 (Reactome)
	Pi	Arrow	5399470 (Reactome)
bHMG-CoA	(R)-mevalonate	Arrow	5400564 (Reactome)