Serotonin receptor 2 and STAT3 signaling (Bos taurus)

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1, 7, 9, 11, 13...10, 16122-6, 17, 188STAT3serotoninHTR2AJAK2GNAQ


Description

This pathway depicts the downstream signaling of serotonin via receptor 2A, resulting in the activation of STAT3.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP733(74441) with a 100.0% conversion rate.

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Bibliography

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  1. Flowers LO, Subramaniam PS, Johnson HM; ''A SOCS-1 peptide mimetic inhibits both constitutive and IL-6 induced activation of STAT3 in prostate cancer cells.''; Oncogene, 2005 PubMed Europe PMC Scholia
  2. Butts DA, Rokhsar DS; ''The information content of spontaneous retinal waves.''; J Neurosci, 2001 PubMed Europe PMC Scholia
  3. Goppelt-Struebe M, Stroebel M; ''Mechanisms of serotonin-induced Ca2+ responses in mesangial cells.''; Naunyn Schmiedebergs Arch Pharmacol, 1997 PubMed Europe PMC Scholia
  4. Imada-Shirakata Y, Kotera T, Ueda S, Okuma M; ''Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC Scholia
  5. Cox DA, Watts SW, Cohen ML; ''Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.''; J Pharmacol Exp Ther, 1996 PubMed Europe PMC Scholia
  6. Dougalis A, Lees G, Ganellin CR; ''The sleep inducing brain lipid cis-oleamide (cOA) does not modulate serotonergic transmission in the CA1 pyramidal neurons of the hippocampus in vitro.''; Neuropharmacology, 2004 PubMed Europe PMC Scholia
  7. Hattori R, Maulik N, Otani H, Zhu L, Cordis G, Engelman RM, Siddiqui MA, Das DK; ''Role of STAT3 in ischemic preconditioning.''; J Mol Cell Cardiol, 2001 PubMed Europe PMC Scholia
  8. Guillet-Deniau I, Burnol AF, Girard J; ''Identification and localization of a skeletal muscle secrotonin 5-HT2A receptor coupled to the Jak/STAT pathway.''; J Biol Chem, 1997 PubMed Europe PMC Scholia
  9. Waris G, Turkson J, Hassanein T, Siddiqui A; ''Hepatitis C virus (HCV) constitutively activates STAT-3 via oxidative stress: role of STAT-3 in HCV replication.''; J Virol, 2005 PubMed Europe PMC Scholia
  10. Damjanoska KJ, Van de Kar LD, Kindel GH, Zhang Y, D'Souza DN, Garcia F, Battaglia G, Muma NA; ''Chronic fluoxetine differentially affects 5-hydroxytryptamine (2A) receptor signaling in frontal cortex, oxytocin- and corticotropin-releasing factor-containing neurons in rat paraventricular nucleus.''; J Pharmacol Exp Ther, 2003 PubMed Europe PMC Scholia
  11. Murata S, Usuda N, Okano A, Kobayashi S, Suzuki T; ''Occurrence of a transcription factor, signal transducer and activators of transcription 3 (Stat3), in the postsynaptic density of the rat brain.''; Brain Res Mol Brain Res, 2000 PubMed Europe PMC Scholia
  12. Ferrand A, Kowalski-Chauvel A, Bertrand C, Escrieut C, Mathieu A, Portolan G, Pradayrol L, Fourmy D, Dufresne M, Seva C; ''A novel mechanism for JAK2 activation by a G protein-coupled receptor, the CCK2R: implication of this signaling pathway in pancreatic tumor models.''; J Biol Chem, 2005 PubMed Europe PMC Scholia
  13. Lo RK, Wong YH; ''Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediates.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  14. Ni CW, Hsieh HJ, Chao YJ, Wang DL; ''Interleukin-6-induced JAK2/STAT3 signaling pathway in endothelial cells is suppressed by hemodynamic flow.''; Am J Physiol Cell Physiol, 2004 PubMed Europe PMC Scholia
  15. Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y; ''Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling.''; Nat Cell Biol, 2004 PubMed Europe PMC Scholia
  16. Li Q, Muma NA, Battaglia G, Van de Kar LD; ''Fluoxetine gradually increases [125I]DOI-labelled 5-HT2A/2C receptors in the hypothalamus without changing the levels of Gq- and G11-proteins.''; Brain Res, 1997 PubMed Europe PMC Scholia
  17. Boyarsky BK, Haque W, Rouleau MR, Hirschfeld RM; ''Sexual functioning in depressed outpatients taking mirtazapine.''; Depress Anxiety, 1999 PubMed Europe PMC Scholia
  18. Piera MJ, Beaughard M, Michelin MT, Winslow E, Massingham R; ''Lack of efficacy of 5-HT2A receptor antagonists to reduce brain damage after 3 minutes of transient global cerebral ischaemia in gerbils.''; Fundam Clin Pharmacol, 1995 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
125631view01:58, 6 March 2023AlexanderPicoModified description
117602view11:37, 21 May 2021EweitzModified title
101985view21:15, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
80659view15:21, 30 June 2015MkutmonNew pathway

External references

DataNodes

NameTypeDatabase referenceComment
GNAQGeneProductENSBTAG00000009789 (Ensembl)
  • guanine nucleotide binding protein, alpha q polypeptide
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
HTR2AGeneProductENSBTAG00000013498 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 2A
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3356
JAK2GeneProductENSBTAG00000012047 (Ensembl)
  • Janus kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3717
STAT3GeneProductENSBTAG00000021523 (Ensembl)
  • signal transducer and activator of transcription
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6774
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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