Diclofenac metabolic pathway (Bos taurus)

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14'-hydroxydiclofenacdiclofenac5-hydroxydiclofenac3'-HydroxydiclofenacCYP2C9CYP2B6CYP2C84',5-DihydroxydiclofenacMetaboliteCYP2C18CYP2C19CYP2C9


Description

CYP metabolism of the diclofenac drug.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2491(73891) with a 66.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bort R, Macé K, Boobis A, Gómez-Lechón MJ, Pfeifer A, Castell J; ''Hepatic metabolism of diclofenac: role of human CYP in the minor oxidative pathways.''; Biochem Pharmacol, 1999 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
117495view11:03, 21 May 2021EweitzModified title
80717view15:23, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
3'-HydroxydiclofenacMetabolite112230 (PubChem-compound)
4',5-DihydroxydiclofenacMetabolite3052567 (PubChem-compound)
4'-hydroxydiclofenacMetabolite116545 (PubChem-compound)
5-hydroxydiclofenacMetabolite3052566 (PubChem-compound)
CYP2B6ProteinENSBTAG00000003871 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P20813
CYP2C18ProteinENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P33260
CYP2C19ProteinENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P33261
CYP2C8ProteinENSBTAG00000020375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P10632
CYP2C9Protein
MetaboliteMetabolite10065052 (PubChem-compound)
diclofenacMetabolite3033 (PubChem-compound)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP3152"
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