Angiogenesis (Bos taurus)

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3Target GenesTarget genesCytoplasmNucleusVascularPermeabilityVessel StabilizationEPC mobilizationBasement membranedegradationSurvivalHREProliferationMigrationStabilization of newly formedvesselsCell growth and divisionAttraction of pericytes and SMCsUpregulation proteasesCel replicationCapillary tubule formationProliferation and differentiationof ECs, SMCs and fibroblastsExtracellularDNAVascular budding throughEPC recruitionTEKSRCNOS3FGF2MMP9TIMP2MMP9MAPK14HIF1AMAPK1AKT1TEKVEGFAHIF1AKDRANGPT1TIMP3PDGFBPDGFBARNTFGF2MMP9VEGFAPDGFRASMAD1FLT1PTK2MMP9PIK3CAANGPT1CREBBPFGFR2PLCG14, 6, 84, 6, 84, 6, 81, 5, 9, 1112, 144, 6, 87, 9, 131, 5, 9, 114, 6, 89, 104, 6, 89, 1012, 149, 109, 107, 9, 13371, 5, 9, 117, 9, 133, 412, 14Hypoxia


Description

This pathway is a concise and simplified version of the basic proteins involved in angiogenesis. The proces is regulated by hyopoxia, which results in the transcription of eg. VEGF1, FGF2, PDGFbeta, MMP9, MMP2 and Ang1. These proteins bind to their receptors and by doing this they initiate different pathways that result in vessel formation.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1539(79949) with a 100.0% conversion rate.

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Bibliography

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  1. Tomanek RJ, Sandra A, Zheng W, Brock T, Bjercke RJ, Holifield JS; ''Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesis.''; Circ Res, 2001 PubMed Europe PMC Scholia
  2. ''3: Angiogenesis Pathway''; http://www.cst.neb.com/reference/pathway/Angiogenesis.html, 2008
  3. http://www.cst.neb.com/reference/pathway/Angiogenesis.html.; ''Angiogenesis Pathway''; http://www.cst.neb.com/reference/pathway/Angiogenesis.html., 2008
  4. Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D; ''Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
  5. Tomanek RJ, Zheng W, Yue X; ''Growth factor activation in myocardial vascularization: therapeutic implications.''; Mol Cell Biochem, 2004 PubMed Europe PMC Scholia
  6. Renault MA, Losordo DW; ''The matrix revolutions: matrix metalloproteinase, vasculogenesis, and ischemic tissue repair.''; Circ Res, 2007 PubMed Europe PMC Scholia
  7. Novotny NM, Lahm T, Markel TA, Crisostomo PR, Wang M, Wang Y, Tan J, Meldrum DR; ''Angiopoietin-1 in the treatment of ischemia and sepsis.''; Shock, 2009 PubMed Europe PMC Scholia
  8. Burbridge MF, Cogâˆڑأ‰آ¬آ© F, Galizzi JP, Boutin JA, West DC, Tucker GC; ''The role of the matrix metalloproteinases during in vitro vessel formation.''; Angiogenesis, 2002 PubMed Europe PMC Scholia
  9. Kutryk MJ, Stewart DJ; ''Angiogenesis of the heart.''; Microsc Res Tech, 2003 PubMed Europe PMC Scholia
  10. Madeddu P; ''Therapeutic angiogenesis and vasculogenesis for tissue regeneration.''; Exp Physiol, 2005 PubMed Europe PMC Scholia
  11. Millauer B, Wizigmann-Voos S, Schnâˆڑأ‰آ¬آ؛rch H, Martinez R, Mâˆڑأ‰آ¬âˆڈller NP, Risau W, Ullrich A; ''High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis.''; Cell, 1993 PubMed Europe PMC Scholia
  12. Hellberg C, Ostman A, Heldin CH; ''PDGF and vessel maturation.''; Recent Results Cancer Res, 2010 PubMed Europe PMC Scholia
  13. Koblizek TI, Weiss C, Yancopoulos GD, Deutsch U, Risau W; ''Angiopoietin-1 induces sprouting angiogenesis in vitro.''; Curr Biol, 1998 PubMed Europe PMC Scholia
  14. Li J, Wei Y, Liu K, Yuan C, Tang Y, Quan Q, Chen P, Wang W, Hu H, Yang L; ''Synergistic effects of FGF-2 and PDGF-BB on angiogenesis and muscle regeneration in rabbit hindlimb ischemia model.''; Microvasc Res, 2010 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
128739view04:47, 21 February 2024EweitzRemove obsolete availability field
128738view04:46, 21 February 2024EweitzUpgrade disease node
80764view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142208
ANGPT1GeneProductENSBTAG00000014051 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15389
ARNTGeneProductENSBTAG00000021037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:405
CREBBPGeneProductENSBTAG00000026403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1387
FGF2GeneProductENSBTAG00000005691 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138685
FGFR2GeneProductENSBTAG00000014064 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2263
FLT1GeneProductENSBTAG00000016915 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102755
HIF1AGeneProductENSBTAG00000020935 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3091
HypoxiaQ105688 (Wikidata)
KDRGeneProductENSBTAG00000000782 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3791
MAPK14GeneProductENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1432
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
MMP9GeneProductENSBTAG00000020676 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100985
NOS3GeneProductENSBTAG00000017680 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164867
PDGFBGeneProductENSBTAG00000021697 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100311
PDGFRAGeneProductENSBTAG00000007173 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P16234
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5290
PLCG1GeneProductENSBTAG00000017584 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000124181
PTK2GeneProductENSBTAG00000009578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q05397
SMAD1GeneProductENSBTAG00000002835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170365
SRCGeneProductENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197122
TEKGeneProductENSBTAG00000020148 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:7010
TIMP2GeneProductENSBTAG00000010899 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000035862
TIMP3ProteinENSBTAG00000020638 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100234
VEGFAGeneProductENSBTAG00000047561 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P15692

Annotated Interactions

No annotated interactions
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