Liver X receptor pathway (Bos taurus)

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9Transcription factorsTranscriptionDrug and steroid metabolismMulti-drug resistanceOtherNR1H320LXR ligandNR1H3LigandGenesTATA boxNR1H3LigandLXRERXRA5, 24RXRA5, 24ABCG820CYP3A4ABCG52120CYP2B621CYP7A1SREBF12121FASN21LXR target genesSCD


Description

The liver X receptor (LXR) is a nuclear receptor involved in the regulation of liver-specific processes, such as cholesterol, fatty acid and glucose homeostasis.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2874(79886) with a 100.0% conversion rate.

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Ontology Terms

 

Bibliography

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  11. Gao H, Fält S, Sandelin A, Gustafsson JA, Dahlman-Wright K; ''Genome-wide identification of estrogen receptor alpha-binding sites in mouse liver.''; Mol Endocrinol, 2008 PubMed Europe PMC Scholia
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  13. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  14. Weiss C, Faust D, Schreck I, Ruff A, Farwerck T, Melenberg A, Schneider S, Oesch-Bartlomowicz B, Zatloukalová J, Vondrácek J, Oesch F, Dietrich C; ''TCDD deregulates contact inhibition in rat liver oval cells via Ah receptor, JunD and cyclin A.''; Oncogene, 2008 PubMed Europe PMC Scholia
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  17. Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong QH, Owens IS, Negishi M, Sueyoshi T; ''The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.''; Hepatology, 2001 PubMed Europe PMC Scholia
  18. Pascussi JM, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem MJ; ''The expression of CYP2B6, CYP2C9 and CYP3A4 genes: a tangle of networks of nuclear and steroid receptors.''; Biochim Biophys Acta, 2003 PubMed Europe PMC Scholia
  19. Gadaleta RM, van Mil SW, Oldenburg B, Siersema PD, Klomp LW, van Erpecum KJ; ''Bile acids and their nuclear receptor FXR: Relevance for hepatobiliary and gastrointestinal disease.''; Biochim Biophys Acta, 2010 PubMed Europe PMC Scholia
  20. Hashimoto K, Mori M; ''Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond [Review].''; Endocr J, 2011 PubMed Europe PMC Scholia
  21. Handschin C, Meyer UA; ''Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR.''; Arch Biochem Biophys, 2005 PubMed Europe PMC Scholia
  22. Hariparsad N, Chu X, Yabut J, Labhart P, Hartley DP, Dai X, Evers R; ''Identification of pregnane-X receptor target genes and coactivator and corepressor binding to promoter elements in human hepatocytes.''; Nucleic Acids Res, 2009 PubMed Europe PMC Scholia
  23. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  24. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  25. Echchgadda I, Song CS, Roy AK, Chatterjee B; ''Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor.''; Mol Pharmacol, 2004 PubMed Europe PMC Scholia
  26. Rodríguez-Sosa M, Elizondo G, López-Durán RM, Rivera I, Gonzalez FJ, Vega L; ''Over-production of IFN-gamma and IL-12 in AhR-null mice.''; FEBS Lett, 2005 PubMed Europe PMC Scholia
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  28. Pavek P, Dvorak Z; ''Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.''; Curr Drug Metab, 2008 PubMed Europe PMC Scholia
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  31. Timsit YE, Negishi M; ''CAR and PXR: the xenobiotic-sensing receptors.''; Steroids, 2007 PubMed Europe PMC Scholia
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  33. Han S, Chiang JY; ''Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes.''; Drug Metab Dispos, 2009 PubMed Europe PMC Scholia
  34. Cai Y, Konishi T, Han G, Campwala KH, French SW, Wan YJ; ''The role of hepatocyte RXR alpha in xenobiotic-sensing nuclear receptor-mediated pathways.''; Eur J Pharm Sci, 2002 PubMed Europe PMC Scholia
  35. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia
  36. Nilsson S, Gustafsson JÅ; ''Estrogen receptors: therapies targeted to receptor subtypes.''; Clin Pharmacol Ther, 2011 PubMed Europe PMC Scholia
  37. Echchgadda I, Song CS, Oh T, Ahmed M, De La Cruz IJ, Chatterjee B; ''The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase.''; Mol Endocrinol, 2007 PubMed Europe PMC Scholia
  38. Lindsey S, Papoutsakis ET; ''''; , PubMed Europe PMC Scholia
  39. Bock KW; ''From differential induction of UDP-glucuronosyltransferases in rat liver to characterization of responsible ligand-activated transcription factors, and their multilevel crosstalk in humans.''; Biochem Pharmacol, 2011 PubMed Europe PMC Scholia
  40. Smoak KA, Cidlowski JA; ''Mechanisms of glucocorticoid receptor signaling during inflammation.''; Mech Ageing Dev, 2004 PubMed Europe PMC Scholia
  41. Rochette-Egly C, Germain P; ''Dynamic and combinatorial control of gene expression by nuclear retinoic acid receptors (RARs).''; Nucl Recept Signal, 2009 PubMed Europe PMC Scholia
  42. Willson TM, Kliewer SA; ''PXR, CAR and drug metabolism.''; Nat Rev Drug Discov, 2002 PubMed Europe PMC Scholia
  43. Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT; ''Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.''; J Biol Chem, 2003 PubMed Europe PMC Scholia
  44. Maglich JM, Watson J, McMillen PJ, Goodwin B, Willson TM, Moore JT; ''The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
  45. Drocourt L, Ourlin JC, Pascussi JM, Maurel P, Vilarem MJ; ''Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.''; J Biol Chem, 2002 PubMed Europe PMC Scholia
  46. Wang JC, Derynck MK, Nonaka DF, Khodabakhsh DB, Haqq C, Yamamoto KR; ''''; , PubMed Europe PMC Scholia
  47. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
116464view10:06, 7 May 2021EweitzModified title
88693view15:56, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
80770view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCG5GeneProductENSBTAG00000016365 (Ensembl)
  • ATP-binding cassette, sub-family G (WHITE), member 5
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64240
ABCG8GeneProductENSBTAG00000016366 (Ensembl)
  • ATP-binding cassette, sub-family G (WHITE), member 8
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:64241
CYP2B6GeneProductENSBTAG00000003871 (Ensembl)
  • cytochrome P450, family 2, subfamily B, polypeptide 6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1555
CYP3A4GeneProductENSBTAG00000047379 (Ensembl)
  • cytochrome P450, family 3, subfamily A, polypeptide 4
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1576
CYP7A1GeneProductENSBTAG00000005287 (Ensembl)
  • cytochrome P450, family 7, subfamily A, polypeptide 1 , is not affected in human
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:1581
FASNGeneProductENSBTAG00000015980 (Ensembl)
  • fatty acid synthase
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2194
LXR ligandMetaboliteCHEBI:48705 (ChEBI) T3
LigandMetaboliteCHEBI:48705 (ChEBI)
NR1H3GeneProductENSBTAG00000010681 (Ensembl)
  • nuclear receptor subfamily 1, group H, member 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10062
RXRAGeneProductENSBTAG00000017851 (Ensembl)
  • retinoid X receptor, alpha
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6256
SCDGeneProductENSBTAG00000047957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6319
SREBF1GeneProductENSBTAG00000007884 (Ensembl)
  • sterol regulatory element binding transcription factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6720

Annotated Interactions

No annotated interactions
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