Felbamate metabolism (Bos taurus)

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Description

CYP metabolism of felbamate, with the metabolites 2-hydroxyfelbamate, p-hydroxyfelbamate, and 3-Hydroxy-2-phenylpropylcarbamate. The last further metabolizes to 3-carbamoyl-2-phenylpropionaldehyde, atropaldehyde, and 3-carbamoyl-2-phenylpropionic acid.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2816(76465) with a 66.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Glue P, Banfield CR, Perhach JL, Mather GG, Racha JK, Levy RH; ''Pharmacokinetic interactions with felbamate. In vitro-in vivo correlation.''; Clin Pharmacokinet, 1997 PubMed Europe PMC Scholia
  2. Husain Z, Pinto C, Sofia RD, Yunis EJ; ''Felbamate-induced apoptosis of hematopoietic cells is mediated by redox-sensitive and redox-independent pathways.''; Epilepsy Res, 2002 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
142450view18:42, 16 February 2026EgonwModified description
117514view11:06, 21 May 2021EweitzModified title
105961view11:49, 16 August 2019MaintBotHMDB identifier normalization
80772view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1.1.1.1Protein
1.2.1.5Protein
2-hydroxyfelbamateMetabolite8575477 (Chemspider)
3-Hydroxy-2-phenylpropyl carbamateMetabolite184751 (Chemspider)
3-carbamoyl-2-phenyl propionaldehydeMetabolite21350391 (PubChem-compound)
3-carbamoyl-2-phenyl propionic acidMetabolite3025746 (PubChem-compound)
CYP2E1GeneProductENSBTAG00000018365 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130649
CYP3A4GeneProductENSBTAG00000047379 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160868
FelbamateMetaboliteHMDB0015084 (HMDB)
atropaldehydeMetabolite10312 (PubChem-compound)
p-hydroxyfelbamateMetabolite8096945 (Chemspider)

Annotated Interactions

No annotated interactions
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