SREBP signaling (Bos taurus)

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ERNucleus4423, 35213026Golgi COPII coated vesicleLipogenic enzymes11Up regulationSREExact mechanism unknownInhibitionCholesterol effluxstimulationCofactorLegendPositive effectNegative effectCholesterol synthesisCatalysisAMPKTranscription-Translation Cleavage17CholesterolRBP4MBTPS1MTORPRKAG2PRKAB2INSIG1bta-mir-33aPIK3CASIRT1NR1H2SREBF2OxysterolsUFAsPRKAA1GSK3APRKAG1AMFRAKT1PRKAB1SREBF1FGF21NFYAGlutamineHMGCRPRKAG3LPIN1Glucosebta-mir-33bPRKAA2InsulinCDK8KPNB1CATHL3SCAPPRKACAPUFAsRNF139ATF6279168SCAP36, 374013, 391, 38420, 2219332, 28, 32151635242510454134SCAPINSIG2INSIG1INSIG2SREBF112, 31SREBF2SREBF1SREBF2SREBF1SAR1ASCAPSREBF2SREBF1SAR1BSAR1ASAR1BSEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSEC13SEC31ASEC31BSEC13SEC23ASEC23BSEC24ASEC24BSEC24CSEC24DSAR1ASCAPSREBF2SREBF1SAR1BSEC31ASEC31BMBTPS242SCAPSREBF2SREBF1SREBF1GeneSRESREBF2GeneCholesterogenic enzymesLipoprotein metabolismCholesterol uptakeCofactorCREB1SP118NFYACREB1SP1YY16, 14YY1PPARGC1BMED1543MED157LSSHMGCS1MVDIDI1FDPSFDFT1SQLECYP51A1LPLLDLRSCARB1ACACAGPAMFASNDBIACLYMDH1PPARGACSS1SCDFatty aciddegradationFatty acid synthesisSIRT129INSIG1INSIG2SREBF2SREBF1


Description

Sterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcriptional level to maintain cellular lipid homeostasis. In addition, SREBP appears to be involved in a variety of other cellular processes. This pathway of SREBP focusses on the regulation of lipid metabolism by SREBP. The data on which this pathway is based, is derived from a variety of in vitro and in vivo studies using different species, including mouse, rat, hamster and human. This pathway served as the basis for a review about SREBP that was published in Genes and Nutrition: PubMed.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP1982(79943) with a 99.0% conversion rate.

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Bibliography

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  2. Walker AK, Yang F, Jiang K, Ji JY, Watts JL, Purushotham A, Boss O, Hirsch ML, Ribich S, Smith JJ, Israelian K, Westphal CH, Rodgers JT, Shioda T, Elson SL, Mulligan P, Najafi-Shoushtari H, Black JC, Thakur JK, Kadyk LC, Whetstine JR, Mostoslavsky R, Puigserver P, Li X, Dyson NJ, Hart AC, Nأ¤أ¤r AM; ''Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.''; Genes Dev, 2010 PubMed Europe PMC Scholia
  3. Radhakrishnan A, Ikeda Y, Kwon HJ, Brown MS, Goldstein JL; ''Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.''; Proc Natl Acad Sci U S A, 2007 PubMed Europe PMC Scholia
  4. Matsuda M, Korn BS, Hammer RE, Moon YA, Komuro R, Horton JD, Goldstein JL, Brown MS, Shimomura I; ''SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation.''; Genes Dev, 2001 PubMed Europe PMC Scholia
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  40. Irisawa M, Inoue J, Ozawa N, Mori K, Sato R; ''The sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  41. Xia M, Liu Y, Guo H, Wang D, Wang Y, Ling W; ''Retinol binding protein 4 stimulates hepatic SREBP-1 and increases lipogenesis through PGC-1beta-dependent pathway.''; Hepatology, 2013 PubMed Europe PMC Scholia
  42. Ye J, Davأ© UP, Grishin NV, Goldstein JL, Brown MS; ''Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.''; Proc Natl Acad Sci U S A, 2000 PubMed Europe PMC Scholia
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  45. Nagoshi E, Imamoto N, Sato R, Yoneda Y; ''Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip.''; Mol Biol Cell, 1999 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
116414view09:07, 7 May 2021EweitzModified title
106015view11:54, 16 August 2019MaintBotHMDB identifier normalization
80779view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACACAGeneProductENSBTAG00000017567 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000278540
ACLYGeneProductENSBTAG00000016740 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131473
ACSS1GeneProductENSBTAG00000004281 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154930
AKT1GeneProductENSBTAG00000017636 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000142208
AMFRGeneProductENSBTAG00000003798 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159461
ATF6GeneProductENSBTAG00000005227 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118217
CATHL3GeneProductENSBTAG00000031599 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164047
CDK8GeneProductENSBTAG00000016737 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132964
CREB1GeneProductENSBTAG00000005474 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118260
CYP51A1GeneProductENSBTAG00000001992 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001630
CholesterolMetaboliteHMDB0000067 (HMDB)
DBIGeneProductENSBTAG00000009517 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155368
FASNGeneProductENSBTAG00000015980 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169710
FDFT1GeneProductENSBTAG00000012432 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079459
FDPSGeneProductENSBTAG00000003948 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160752
FGF21GeneProductENSBTAG00000011624 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105550
GPAMGeneProductENSBTAG00000011917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000119927
GSK3AGeneProductENSBTAG00000020756 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105723
GlucoseMetaboliteHMDB0000122 (HMDB)
GlutamineMetaboliteHMDB0000641 (HMDB)
HMGCRGeneProductENSBTAG00000007840 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113161
HMGCS1GeneProductENSBTAG00000011839 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112972
IDI1GeneProductENSBTAG00000004075 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067064
INSIG1GeneProductENSBTAG00000001592 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000186480
INSIG2GeneProductENSBTAG00000002112 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125629
InsulinProtein
KPNB1GeneProductENSBTAG00000006586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108424
LDLRGeneProductENSBTAG00000012314 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130164
LPIN1GeneProductENSBTAG00000007689 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134324
LPLGeneProductENSBTAG00000012855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000175445
LSSGeneProductENSBTAG00000018936 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000160285
MBTPS1GeneProductENSBTAG00000010170 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000140943
MBTPS2GeneProductENSBTAG00000008183 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000012174
MDH1GeneProductENSBTAG00000019295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000014641
MED15GeneProductENSBTAG00000018048 (Ensembl)
  • activator recruited cofactor (ARC)-mediator activator complex
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099917
MTORGeneProductENSBTAG00000015325 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198793
MVDGeneProductENSBTAG00000012059 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000167508
NFYAGeneProductENSBTAG00000009905 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000001167
NR1H2GeneProductENSBTAG00000003264 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131408
OxysterolsMetaboliteCHEBI:53030 (ChEBI)
PIK3CAGeneProductENSBTAG00000009232 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121879
PPARGC1BGeneProductENSBTAG00000012943 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155846
PPARGGeneProductENSBTAG00000001333 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132170
PRKAA1GeneProductENSBTAG00000000013 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132356
PRKAA2GeneProductENSBTAG00000018747 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000162409
PRKAB1GeneProductENSBTAG00000005940 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111725
PRKAB2GeneProductENSBTAG00000014387 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131791
PRKACAGeneProductENSBTAG00000006642 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072062
PRKAG1GeneProductENSBTAG00000014426 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000181929
PRKAG2GeneProductENSBTAG00000002917 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106617
PRKAG3GeneProductENSBTAG00000013492 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115592
PUFAsMetaboliteCHEBI:26208 (ChEBI) Inhibition of SREBP1 processing
RBP4GeneProductENSBTAG00000000442 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138207
RNF139GeneProductENSBTAG00000020399 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170881
SAR1AGeneProductENSBTAG00000016858 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000079332
SAR1BGeneProductENSBTAG00000021226 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152700
SCAPGeneProductENSBTAG00000015782 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000114650
SCARB1GeneProductENSBTAG00000014269 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000073060
SCDGeneProductENSBTAG00000047957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000099194
SEC13GeneProductENSBTAG00000017825 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157020
SEC23AGeneProductENSBTAG00000003708 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100934
SEC23BGeneProductENSBTAG00000018295 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101310
SEC24AGeneProductENSBTAG00000018322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113615
SEC24BGeneProductENSBTAG00000010945 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138802
SEC24CGeneProductENSBTAG00000002791 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176986
SEC24DGeneProductENSBTAG00000003619 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000150961
SEC31AGeneProductENSBTAG00000020525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138674
SEC31BGeneProductENSBTAG00000000090 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000075826
SIRT1GeneProductENSBTAG00000014023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000096717
SP1GeneProductENSBTAG00000003021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000185591
SQLEGeneProductENSBTAG00000005498 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000104549
SREBF1GeneProductENSBTAG00000007884 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000072310
SREBF2GeneProductENSBTAG00000014265 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000198911
UFAsMetaboliteCHEBI:26208 (ChEBI)
YY1GeneProductENSBTAG00000020819 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100811
bta-mir-33aRnaENSBTAG00000029975 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Mb:MI0000091
bta-mir-33bRnaENSBTAG00000036437 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = Mb:MI0003646

Annotated Interactions

No annotated interactions
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