Metastatic brain tumor (Bos taurus)

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23, 41CpG hypermethylationMetastasisDNMTsE2H2CDC42TP53MIR29Abta-let-7a-1E2F3CDK6PIK3R1TTPbta-mir-148aMYCbta-mir-34abta-mir-148bbta-mir-101-1bta-mir-101-2bta-mir-34bbta-mir-34cMIR29B1MIR29B2MIR29Cbta-let-7a-2bta-let-7a-3MIRLET7Bbta-let-7cbta-let-7dbta-let-7ebta-let-7f-1bta-let-7f-2bta-let-7g


Description

Interaction between microRNAs (miRNAs) and abnormal methylation to control metastasis.

Tumor growth and metastasis formation through down regulation of their oncogenic targets such as MYC ,E2F3 and cyclin-dependent kinase(CDK6).

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2249(80457) with a 75.0% conversion rate.

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Ontology Terms

 

Bibliography

  1. Hafner M, Landthaler M, Burger L, Khorshid M, Hausser J, Berninger P, Rothballer A, Ascano M Jr, Jungkamp AC, Munschauer M, Ulrich A, Wardle GS, Dewell S, Zavolan M, Tuschl T; ''Transcriptome-wide identification of RNA-binding protein and microRNA target sites by PAR-CLIP.''; Cell, 2010 PubMed Europe PMC Scholia
  2. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  3. Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia
  4. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, Pilpel Y, Nielsen FC, Oren M, Lund AH; ''p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC.''; Cell Death Differ, 2010 PubMed Europe PMC Scholia

History

CompareRevisionActionTimeUserComment
89837view12:11, 6 October 2016MkutmonModified description
87810view11:28, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87809view11:28, 25 July 2016ElisaOntology Term : 'disease pathway' added !
80900view15:30, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CDC42GeneProductENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831
CDK6GeneProductENSBTAG00000044023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105810
E2F3GeneProductENSBTAG00000021045 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000112242
E2H2GeneProduct
MIR29ARna
MIR29B1Rna
MIR29B2Rna
MIR29CRna
MIRLET7BRna
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
PIK3R1ProteinENSBTAG00000010989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P27986
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
TTPGeneProduct
bta-let-7a-1RnaENSBTAG00000029981 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406881
bta-let-7a-2RnaENSBTAG00000029881 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406882
bta-let-7a-3RnaENSBTAG00000029772 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406883
bta-let-7cRnaENSBTAG00000029912 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406885
bta-let-7dRnaENSBTAG00000029853 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406886
bta-let-7eRnaENSBTAG00000029880 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406887
bta-let-7f-1RnaENSBTAG00000029935 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406888
bta-let-7f-2RnaENSBTAG00000029774 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406889
bta-let-7gRnaENSBTAG00000029861 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:406890
bta-mir-101-1RnaENSBTAG00000029855 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199135
bta-mir-101-2RnaENSBTAG00000029932 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199065
bta-mir-148aRnaENSBTAG00000029945 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199085
bta-mir-148bRnaENSBTAG00000029852 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000199122
bta-mir-34aRnaENSBTAG00000029924 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207865
bta-mir-34bRnaENSBTAG00000029856 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207811
bta-mir-34cRnaENSBTAG00000029991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207562

Annotated Interactions

No annotated interactions
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