Chemical compounds to monitor proteins (Homo sapiens)

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Bibliography

1. Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, Plunket KD, Creech KL, Moore LB, Wilson JG, Lewis MC, Jones SA, Willson TM; ''Identification of a chemical tool for the orphan nuclear receptor FXR.''; J Med Chem, 2000 PubMed Europe PMC Scholia
2. Picaud S, Da Costa D, Thanasopoulou A, Filippakopoulos P, Fish PV, Philpott M, Fedorov O, Brennan P, Bunnage ME, Owen DR, Bradner JE, Taniere P, O'Sullivan B, Müller S, Schwaller J, Stankovic T, Knapp S; ''PFI-1, a highly selective protein interaction inhibitor, targeting BET Bromodomains.''; Cancer Res, 2013 PubMed Europe PMC Scholia
3. Pellicciari R, Fiorucci S, Camaioni E, Clerici C, Costantino G, Maloney PR, Morelli A, Parks DJ, Willson TM; ''6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity.''; J Med Chem, 2002 PubMed Europe PMC Scholia
4. Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ; ''The promise and peril of chemical probes.''; Nat Chem Biol, 2015 PubMed Europe PMC Scholia
5. Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, Morse EM, Keates T, Hickman TT, Felletar I, Philpott M, Munro S, McKeown MR, Wang Y, Christie AL, West N, Cameron MJ, Schwartz B, Heightman TD, La Thangue N, French CA, Wiest O, Kung AL, Knapp S, Bradner JE; ''Selective inhibition of BET bromodomains.''; Nature, 2010 PubMed Europe PMC Scholia
6. Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, Robson SC, Chung CW, Hopf C, Savitski MM, Huthmacher C, Gudgin E, Lugo D, Beinke S, Chapman TD, Roberts EJ, Soden PE, Auger KR, Mirguet O, Doehner K, Delwel R, Burnett AK, Jeffrey P, Drewes G, Lee K, Huntly BJ, Kouzarides T; ''Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia.''; Nature, 2011 PubMed Europe PMC Scholia
7. Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB; ''Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC Scholia
8. Ring DB, Johnson KW, Henriksen EJ, Nuss JM, Goff D, Kinnick TR, Ma ST, Reeder JW, Samuels I, Slabiak T, Wagman AS, Hammond ME, Harrison SD; ''Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo.''; Diabetes, 2003 PubMed Europe PMC Scholia

History

External references

DataNodes

Name	Type	Database reference	Comment
(+)-JQ1	Metabolite	46907787 (PubChem-compound)
6-Et CDCA	Metabolite	394730 (Chemspider)
BRD2	GeneProduct	ENSG00000204256 (Ensembl)
BRD3	GeneProduct	ENSG00000169925 (Ensembl)
BRD4	GeneProduct	ENSG00000141867 (Ensembl)
BRDT	GeneProduct	ENSG00000137948 (Ensembl)
CHIR-99021	Metabolite	9956119 (PubChem-compound)
FXR	GeneProduct	NR1H4 (HGNC)
GSK3A	GeneProduct	2931 (Entrez Gene)
GW4064	Metabolite	9893571 (PubChem-compound)
I-BET151	Metabolite	52912189 (PubChem-compound)	http://www.chemicalprobes.org/I-BET151
KOR	GeneProduct	4986 (Entrez Gene)
PFI-1	Metabolite	71271629 (PubChem-compound)
Salvinorin A	Metabolite	113947 (Chemspider)

Annotated Interactions

No annotated interactions