Dual hijack model of Vif in HIV infection (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Gene expressionUbiquitin ligationUbA3GVifELOCELOBCBFBVifRUNX1CBFBCUL5UBBRBX1E2CBFBVifName: Dual hijack model of Vif in HIV infectionOrganism: Homo sapiens


Description

By hijacking CBF-b, Vif (Viral infectivity factor, HIV protein) is manipulating the ubquitination machinery and adversely effecting host transcriptional regulation. This pathways was adapted from figure 3 in [Fraser et al](https://www.ncbi.nlm.nih.gov/pubmed/23352243). Viral proteins are highlighted in yellow.

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access
Image:Featured.pngReview changes for Featured

Ontology Terms

Pathway Ontology : regulatory pathway
 

Bibliography

  1. Fraser JS, Gross JD, Krogan NJ; ''From systems to structure: bridging networks and mechanism.''; Mol Cell, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137950
Approved
view19:05, 10 March 2025KhanspersModified description
102277
Featured
view07:14, 17 December 2018EgonwUpdated Uniprot data source name.
102275view22:50, 16 December 2018Andraupdate vif ids
102274view22:42, 16 December 2018Andraadd uniprot ID
102222view20:56, 11 December 2018KhanspersModified description
102221view20:56, 11 December 2018KhanspersModified description
97835view06:45, 10 June 2018EgonwModified description
97680view13:18, 1 June 2018AMTanOntology Term : 'human immunodeficiency virus infectious disease' added !
87896view12:52, 25 July 2016SusanOntology Term : 'regulatory pathway' added !
85021view19:19, 5 April 2016KhanspersQuick edit to datanode annotation or property
81234view20:25, 6 August 2015Khansperslayout update
81233view19:36, 6 August 2015KhanspersModified description
81232view19:30, 6 August 2015KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
A3GGeneProductENSG00000239713 (Ensembl)
CBFBGeneProductENSG00000067955 (Ensembl)
CUL5GeneProductENSG00000166266 (Ensembl)
E2GeneProductENSG00000067955 (Ensembl)
ELOBGeneProductENSG00000103363 (Ensembl)
ELOCGeneProductENSG00000154582 (Ensembl)
RBX1GeneProductENSG00000100387 (Ensembl)
RUNX1GeneProductENSG00000159216 (Ensembl)
UBBGeneProductENSG00000170315 (Ensembl)
VifGeneProductP69723 (Uniprot-TrEMBL)

Annotated Interactions

No annotated interactions

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