eIF5A regulation in response to inhibition of the nuclear export system (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none NucleusCell survivalSINEEXP4EIF5AIGF2BP1EIF5AEIF5AEIF5AEXP4IGF2BP1XPO1IGF2BP1XPO1Name: eIF5A regulation in response to inhibition of the nuclear export systemOrganism: Homo sapiens


Description

Model of eIF5A regulation in response to inhibition of the nuclear export system. Under normal conditions, IGF2BP1 is exported by XPO1 and binds to eIF5A in cytoplasm. The binding with IGF2BP1 prevents eIF5A from accumulating in mitochondria and inducing apoptosis. SINE (Selective Inhibitors of Nuclear Export) inhibits the nuclear export of IGF2BP1, resulting in decreased cytoplasmic IGF2BP1. Based on figure Figure 6 in Miyake et al (https://europepmc.org/article/MED/25878333)

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Quality Tags

Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

  1. Miyake T, Pradeep S, Wu SY, Rupaimoole R, Zand B, Wen Y, Gharpure KM, Nagaraja AS, Hu W, Cho MS, Dalton HJ, Previs RA, Taylor ML, Hisamatsu T, Kang Y, Liu T, Shacham S, McCauley D, Hawke DH, Wiktorowicz JE, Coleman RL, Sood AK; ''XPO1/CRM1 Inhibition Causes Antitumor Effects by Mitochondrial Accumulation of eIF5A.''; Clin Cancer Res, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
136355view20:25, 29 January 2025KhanspersModified description
136354view20:22, 29 January 2025KhanspersOntology Term : 'cancer pathway' added !
136353view20:21, 29 January 2025Khanspersdecreased board height
136352view20:19, 29 January 2025Khanspersadded Wikidata for SINE, updated layout/logic
123388view06:20, 23 July 2022EgonwMade a pathway clickable
87966view13:14, 25 July 2016SusanOntology Term : 'nuclear protein transport pathway' added !
87384view11:05, 22 July 2016MaintBotadded missing graphids
81679view23:42, 22 August 2015AlexanderPicoAdded pathway node for Apoptosis
81297view00:10, 15 August 2015MaintBotModified description
81296view00:04, 15 August 2015KhanspersNew pathway

External references

DataNodes

Name  ↓Type  ↓Database reference  ↓Comment  ↓
EIF5AGeneProductENSG00000132507 (Ensembl)
EXP4GeneProductENSG00000132953 (Ensembl)
IGF2BP1GeneProductENSG00000159217 (Ensembl)
SINEMetaboliteQ65122840 (Wikidata)
XPO1GeneProductENSG00000082898 (Ensembl)

Annotated Interactions

No annotated interactions

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