Adar1 editing defficiency immune response (Mus musculus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none IFN-aGenes upregulatedby Adar1MitochondrionApol9aOas2Map3k7Tab3Tbk1IkbkeIfi44AdarTicam1Tab2Nlrx1Apol9bMavsIfna1Mx1Oas1gDhx58Gorasp1Tlr3Pydc4IkbkbIfnb1Irf7dsRNAOasl1Tab1Traf3Ddx58Ifih1Irf3Oasl2Mx2IkbkgIsg15Tgtp1Ifnar1Rsad2Slfn4Ifit3Zbp1TankNlrc5Traf6NfkbiaOas3ChukRalbp1Tgtp2Ifit1Irf3Irf7AdarIrf7IkbkgTraf3Traf6dsRNANfkb1Nfkb1Nfkb1Ifngr1Gorasp1Gorasp1CytoplasmnucleusIrf7EndosomeInflamatory genesIFN-BdsRNA (edited)Gm4951Iigp1Cxcl11Gm4955Oas1aUsp18Ddx60Gbp3Gm12185Cxcl10Xaf1Ifnb1Irf7Oas1hGm13822Sp100Ccl5Oas1bGm8696Gbp10Ly6c1Gbp6Gm14446Rtp4Gm5970Ly6aF830016B08Rik4930512H18RikI830012O16Rik9330175E14RikName: Adar1 editing defficiency immune responseOrganism: Mus musculus


Description

RNA editing plays an essential role in mammalian tissue homeostasis and embryonic development and is involved in the pathogenesis of several disorders, i.a. autoimmune and inflammatory diseases. Adar1 is involved in regulation of the innate immune response.

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Quality Tags

Image:NeedsWork.pngNeeds work
Image:MissingXref.pngAnnotate nodes

Ontology Terms

Pathway Ontology : disease pathway
Cell Type : hepatocyte
 

Bibliography

  1. Wang Q, Li X, Qi R, Billiar T; ''RNA Editing, ADAR1, and the Innate Immune Response.''; Genes (Basel), 2017 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
104961view13:10, 27 June 2019Fehrhartadded description and reference for this
104960view13:08, 27 June 2019FehrhartModified description
89963view18:13, 6 October 2016Mkutmonfix unconnected lines
88726view20:27, 12 August 2016MaintBotOntology Term : 'immune response pathway' added !
88725view20:27, 12 August 2016MaintBotOntology Term : 'regulatory pathway' added !
88724view20:26, 12 August 2016MaintBotOntology Term : 'signaling pathway' added !
85388view08:18, 11 May 2016EgonwFixed the NCBI Gene ID.
82889view12:48, 11 November 2015JmeliusCorrect outdated mapping id
81866view04:49, 4 September 2015AlistairchalkPeriodical save, work in progress
81865view04:39, 4 September 2015AlistairchalkPeriodical save, work in progress
81864view04:28, 4 September 2015AlistairchalkPeriodical save, work in progress
81863view04:18, 4 September 2015AlistairchalkPeriodical save, work in progress
81862view04:08, 4 September 2015AlistairchalkPeriodical save, work in progress
81861view03:37, 4 September 2015AlistairchalkPeriodical save, work in progress
81853view07:02, 3 September 2015AlistairchalkPeriodical save, work in progress
81852view07:00, 3 September 2015AlistairchalkdsRNA edited now added.
81851view05:31, 3 September 2015AlistairchalkWith labels.
81850view05:19, 3 September 2015AlistairchalkPeriodical save, work in progress
81849view05:09, 3 September 2015AlistairchalkPeriodical save, work in progress
81848view04:57, 3 September 2015AlistairchalkPeriodical save, work in progress
81847view04:47, 3 September 2015AlistairchalkPeriodical save, work in progress
81846view04:37, 3 September 2015AlistairchalkPeriodical save, work in progress
81842view01:39, 3 September 2015AlistairchalkPeriodical save, work in progress
81841view01:28, 3 September 2015AlistairchalkPeriodical save, work in progress
81840view01:18, 3 September 2015AlistairchalkPeriodical save, work in progress
81839view01:08, 3 September 2015AlistairchalkNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
4930512H18RikGeneProductMGI:1922361 (MGI)
9330175E14RikGeneProduct320377 (Entrez Gene)
AdarGeneProduct56417 (Entrez Gene)
Apol9aGeneProduct223672 (Entrez Gene)
Apol9bGeneProduct71898 (Entrez Gene)
Ccl5GeneProduct20304 (Entrez Gene)
ChukGeneProduct12675 (Entrez Gene)
Cxcl10GeneProduct15945 (Entrez Gene)
Cxcl11GeneProduct56066 (Entrez Gene)
Ddx58GeneProduct230073 (Entrez Gene)
Ddx60GeneProductENSMUSG00000037921 (Ensembl)
Dhx58GeneProduct80861 (Entrez Gene)
F830016B08RikGeneProduct240328 (Entrez Gene)
Gbp10GeneProduct626578 (Entrez Gene)
Gbp3GeneProduct55932 (Entrez Gene)
Gbp6GeneProduct100702 (Entrez Gene)
Gm12185GeneProduct620913 (Entrez Gene)
Gm13822GeneProductMGI:3650351 (MGI)
Gm14446GeneProduct667373 (Entrez Gene)
Gm4951GeneProduct240327 (Entrez Gene)
Gm4955GeneProductMGI:3646410 (MGI)
Gm5970GeneProductMGI:3646761 (MGI)
Gm8696GeneProductMGI:3642963 (MGI)
Gorasp1GeneProduct74498 (Entrez Gene)
I830012O16RikGeneProduct667370 (Entrez Gene)
Ifi44GeneProduct99899 (Entrez Gene)
Ifih1GeneProduct71586 (Entrez Gene)
Ifit1GeneProduct15957 (Entrez Gene)
Ifit3GeneProduct15959 (Entrez Gene)
Ifna1GeneProduct15962 (Entrez Gene)
Ifnar1GeneProduct15975 (Entrez Gene)
Ifnb1GeneProduct15977 (Entrez Gene)
Ifngr1GeneProduct15979 (Entrez Gene)
Iigp1GeneProduct60440 (Entrez Gene)
IkbkbGeneProduct16150 (Entrez Gene)
IkbkeGeneProduct56489 (Entrez Gene)
IkbkgGeneProduct16151 (Entrez Gene)
Irf3GeneProduct54131 (Entrez Gene)
Irf7GeneProduct54123 (Entrez Gene)
Isg15GeneProduct100038882 (Entrez Gene)
Ly6aGeneProduct110454 (Entrez Gene)
Ly6c1GeneProduct17067 (Entrez Gene)
Map3k7GeneProduct26409 (Entrez Gene)
MavsGeneProduct228607 (Entrez Gene)
Mx1GeneProductMGI:97243 (MGI)
Mx2GeneProduct17858 (Entrez Gene)
Nfkb1GeneProduct18033 (Entrez Gene)
NfkbiaGeneProduct18035 (Entrez Gene)
Nlrc5GeneProduct434341 (Entrez Gene)
Nlrx1GeneProduct270151 (Entrez Gene)
Oas1aGeneProduct246730 (Entrez Gene)
Oas1bGeneProduct23961 (Entrez Gene)
Oas1gGeneProduct23960 (Entrez Gene)
Oas1hGeneProduct246729 (Entrez Gene)
Oas2GeneProduct246728 (Entrez Gene)
Oas3GeneProduct246727 (Entrez Gene)
Oasl1GeneProduct231655 (Entrez Gene)
Oasl2GeneProduct23962 (Entrez Gene)
Pydc4GeneProduct623121 (Entrez Gene)
Ralbp1GeneProduct19765 (Entrez Gene)
Rsad2GeneProduct58185 (Entrez Gene)
Rtp4GeneProduct67775 (Entrez Gene)
Slfn4GeneProduct20558 (Entrez Gene)
Sp100GeneProduct20684 (Entrez Gene)
Tab1GeneProduct66513 (Entrez Gene)
Tab2GeneProduct68652 (Entrez Gene)
Tab3GeneProduct66724 (Entrez Gene)
TankGeneProduct21353 (Entrez Gene)
Tbk1GeneProduct56480 (Entrez Gene)
Tgtp1GeneProduct21822 (Entrez Gene)
Tgtp2GeneProduct100039796 (Entrez Gene)
Ticam1GeneProduct106759 (Entrez Gene)
Tlr3GeneProduct142980 (Entrez Gene)
Traf3GeneProduct22031 (Entrez Gene)
Traf6GeneProduct22034 (Entrez Gene)
Usp18GeneProduct24110 (Entrez Gene)
Xaf1GeneProduct327959 (Entrez Gene)
Zbp1GeneProduct58203 (Entrez Gene)
dsRNARna
dsRNA (edited)Rna

Annotated Interactions

No annotated interactions

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