mir-124 predicted interactions with cell cycle and differentiation (Homo sapiens)

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1Neuronal differentiationhsa-miR-124aAMPKSIX4STRADBPTBPKLB1SCP1Cell polarityand differentiationCell cycle progression


Description

Schematic of predicted interactions of miR-124 with cell cycle and cell differentiation machinery. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-124 is selectively toxic, mainly by inducing terminal cell differentiation via its target SIX4.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, Purinton S, Wang Y, Ivan C, Kim HS, Borkowski RJ, Khan S, Rodriguez-Aguayo C, Lopez-Berestein G, Lea J, Gazdar A, Baggerly KA, Sood AK, White MA; ''A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.''; Mol Syst Biol, 2015 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
89883view12:59, 6 October 2016MkutmonModified description
87701view09:00, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
84854view21:53, 28 March 2016Khanspersupdated interactions
83894view00:16, 23 December 2015KhanspersModified description
83889view00:06, 23 December 2015KhanspersNew pathway
83890view00:05, 23 December 2015KhanspersModified description

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AMPKGeneProductENSG00000132356 (Ensembl)
KLB1GeneProductENSG00000118046 (Ensembl)
PTBPGeneProductENSG00000011304 (Ensembl)
SCP1GeneProductENSG00000144579 (Ensembl)
SIX4GeneProductENSG00000100625 (Ensembl)
STRADBGeneProductENSG00000082146 (Ensembl)
hsa-miR-124aRnaMIMAT0000422 (miRBase mature sequence)

Annotated Interactions

No annotated interactions

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