miR-517 relationship with ARCN1 and USP1 (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cell viabilityUSP1ARCN1p21hsa-miR-517a-3pID1ID2Cell cycle progressionName: miR-517 relationship with ARCN1 and USP1Organism: Homo sapiens


Description

Schematic summarizing predicted miR-517a relationships with ARCN1 and USP1.

A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-517a targets a common vulnerability, primarily via its target ARCN1.

Proteins on this pathway have targeted assays available via the [Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3596 CPTAC).

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access

Ontology Terms

Bibliography

  1. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, Purinton S, Wang Y, Ivan C, Kim HS, Borkowski RJ, Khan S, Rodriguez-Aguayo C, Lopez-Berestein G, Lea J, Gazdar A, Baggerly KA, Sood AK, White MA; ''A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.''; Mol Syst Biol, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137164
Approved
view01:03, 28 February 2025KhanspersModified description
105860view23:20, 15 August 2019KhanspersModified description
89884view13:01, 6 October 2016MkutmonModified description
87706view09:05, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
84855view21:54, 28 March 2016Khanspersupdated interactions
83893view00:15, 23 December 2015KhanspersModified description
83891view00:15, 23 December 2015KhanspersNew pathway
83892view00:14, 23 December 2015KhanspersModified description

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ARCN1GeneProductENSG00000095139 (Ensembl)
ID1GeneProductENSG00000125968 (Ensembl)
ID2GeneProductENSG00000115738 (Ensembl)
USP1GeneProductENSG00000162607 (Ensembl)
hsa-miR-517a-3pRnaMIMAT0002852 (miRBase mature sequence)
p21GeneProductENSG00000124762 (Ensembl)

Annotated Interactions

No annotated interactions

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