miR-517 relationship with ARCN1 and USP1 (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cell viabilityUSP1ARCN1p21hsa-miR-517a-3pID1ID2Cell cycle progressionName: miR-517 relationship with ARCN1 and USP1Organism: Homo sapiens


Description

Schematic summarizing predicted miR-517a relationships with ARCN1 and USP1.

A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-517a targets a common vulnerability, primarily via its target ARCN1.

Proteins on this pathway have targeted assays available via the [Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3596 CPTAC).

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access

Ontology Terms

Pathway Ontology : disease pathway
 

Bibliography

  1. Shields BB, Pecot CV, Gao H, McMillan E, Potts M, Nagel C, Purinton S, Wang Y, Ivan C, Kim HS, Borkowski RJ, Khan S, Rodriguez-Aguayo C, Lopez-Berestein G, Lea J, Gazdar A, Baggerly KA, Sood AK, White MA; ''A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression.''; Mol Syst Biol, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137164
Approved
view01:03, 28 February 2025KhanspersModified description
105860view23:20, 15 August 2019KhanspersModified description
89884view13:01, 6 October 2016MkutmonModified description
87706view09:05, 25 July 2016RyanmillerOntology Term : 'regulatory pathway' added !
84855view21:54, 28 March 2016Khanspersupdated interactions
83893view00:15, 23 December 2015KhanspersModified description
83891view00:15, 23 December 2015KhanspersNew pathway
83892view00:14, 23 December 2015KhanspersModified description

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
ARCN1GeneProductENSG00000095139 (Ensembl)
ID1GeneProductENSG00000125968 (Ensembl)
ID2GeneProductENSG00000115738 (Ensembl)
USP1GeneProductENSG00000162607 (Ensembl)
hsa-miR-517a-3pRnaMIMAT0002852 (miRBase mature sequence)
p21GeneProductENSG00000124762 (Ensembl)

Annotated Interactions

No annotated interactions

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