Hepatitis C and hepatocellular carcinoma (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Cell growth and survivalCell migrationBIRC3MAPK14AngiogenesisRRM2WNT signalingCOL4A2RAC1BCL2L1CXCR1BIRC5PI3K signalingMIR34AVAV2STAT3PODXLPTPN11UCHL1MAPK3VEGFAFRZBCell cycle progressionNFKB1 signalingCell proliferationTP53JAK1IL8MMP1MAPK signalingMIR744NFKB1AKT1DNA repairMYOFIL6RBRCA1CD44IL6SOS1CASP9TGFB1CTTNCytoskeleton activationApoptosisE2F2GRB2HIF1AMYCCDKN1ACASP3CASP9CASP7CCND1MYCJUNSMAD3SMAD4Cell migrationAngiogenesisCell proliferationVEGFACCND1IL8MMP1PTGS2NOS2CCND1BIRC3BCL2L1LEF1HNF1AFASLGCDKN1ATNFSS10CCND1MYCMAPK signalingMYCCell proliferationCell proliferationAngiogenesisApoptosisMIR34AMIR155MIR34AMIR155MIR34AMIR155MIR24-1MIR24-2MIR92A1MIR92A2ApoptosisAngiogenesisMIR34AMAPK signalingMAPK8JUNTGFBR1MIR24-1MIR24-2MIR744MAPK signalingApoptosisMIR155Cell proliferationName: Hepatitis C and hepatocellular carcinomaOrganism: Homo sapiens


Description

Pathway model based on hub miRNAs and their putative targets from network analysis.
  • From a set of differentially expressed genes in both chronic HCV (hepatitis C virus) and HCC (hepatocellular carcinoma) samples, a protein-protein network was constructed using [STRING](http://string-db.org/) and [GeneMANIA](http://genemania.org/).
  • After topological analysis and network visualization in Cytoscape, the top hub genes were identified.
  • miRNAs related to hub genes were identified using miRTarBase server and combined with the PPI network to constructed a miRNA-Hubgene network.

Based on Figure 4 from Poortahmasebi et al, How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.

Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3646).

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Quality Tags

Ontology Terms

 

Bibliography

  1. Poortahmasebi V, Poorebrahim M, Najafi S, Jazayeri SM, Alavian SM, Arab SS, Ghavami S, Alavian SE, Rezaei Moghadam A, Amiri M; ''How Hepatitis C Virus Leads to Hepatocellular Carcinoma: A Network-Based Study.''; Hepat Mon, 2016 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137152view23:24, 27 February 2025KhanspersModified description
135169view00:57, 7 August 2024EweitzClear cache to fix board height
135168view00:55, 7 August 2024EweitzEconomize layout
135167view00:49, 7 August 2024EweitzIncrease font size
128258view00:16, 30 January 2024EweitzStandardize case
116732view10:58, 11 May 2021EweitzModified title
111190view07:11, 23 July 2020EgonwMade a few more pathway nodes clickable
107467view18:45, 10 October 2019KhanspersModified description
106591view19:33, 10 September 2019KhanspersModified description
105615view04:56, 10 August 2019KhanspersModified description
103011view15:22, 31 January 2019Mkutmonupdated outdated Ensembl identifier (MIR34A)
102150view18:57, 4 December 2018Khanspersupdated mirna identifiers
97632view10:53, 31 May 2018AMTanOntology Term : 'hepatocellular carcinoma' added !
88640view14:54, 12 August 2016JmeliusOntology Term : 'disease pathway' added !
85722view23:14, 6 June 2016KhanspersModified description
85720view20:53, 6 June 2016KhanspersAdded one final interaction
85719view20:49, 6 June 2016KhanspersModified description
85718view20:48, 6 June 2016KhanspersModified description
85714view20:39, 6 June 2016KhanspersModified description
85713view20:39, 6 June 2016KhanspersModified description
85700view18:34, 6 June 2016KhanspersOntology Term : 'hepatocyte' added !
85699view18:33, 6 June 2016KhanspersOntology Term : 'carcinoma' added !
85698view18:32, 6 June 2016KhanspersOntology Term : 'hepatitis' added !
85697view18:31, 6 June 2016KhanspersModified description
85696view18:28, 6 June 2016Khanspersupdate
85566view22:54, 31 May 2016KhanspersNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductENSG00000142208 (Ensembl)
AngiogenesisPathwayWP1539 (WikiPathways)
ApoptosisPathwayWP254 (WikiPathways)
BCL2L1GeneProductENSG00000171552 (Ensembl)
BIRC3GeneProductENSG00000023445 (Ensembl)
BIRC5GeneProductENSG00000089685 (Ensembl)
BRCA1GeneProductENSG00000012048 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CD44GeneProductENSG00000026508 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
COL4A2GeneProductENSG00000134871 (Ensembl)
CTTNGeneProductENSG00000085733 (Ensembl)
CXCR1GeneProductENSG00000163464 (Ensembl)
Cell cycle progressionPathwayWP45 (WikiPathways)
Cell migrationPathway
Cell proliferationPathway
Cytoskeleton activationPathway
DNA repairPathwayWP707 (WikiPathways)
E2F2GeneProductENSG00000007968 (Ensembl)
FASLGGeneProductENSG00000117560 (Ensembl)
FRZBGeneProductENSG00000162998 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HNF1AGeneProductENSG00000135100 (Ensembl)
IL6GeneProductENSG00000136244 (Ensembl)
IL6RGeneProductENSG00000160712 (Ensembl)
IL8GeneProductENSG00000169429 (Ensembl)
JAK1GeneProductENSG00000162434 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MAPK signalingPathwayWP382 (WikiPathways)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MIR155GeneProductENSG00000283904 (Ensembl)
MIR24-1GeneProductENSG00000284459 (Ensembl)
MIR24-2GeneProductENSG00000284387 (Ensembl)
MIR34AGeneProductENSG00000284357 (Ensembl)
MIR744GeneProductENSG00000266297 (Ensembl)
MIR92A1GeneProductMIR92A1 (HGNC)
MIR92A2GeneProductENSG00000284538 (Ensembl)
MMP1GeneProductENSG00000196611 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MYOFGeneProductENSG00000138119 (Ensembl)
NFKB1 signalingPathway
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
PI3K signalingPathway
PODXLGeneProductENSG00000128567 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
PTPN11GeneProductENSG00000179295 (Ensembl)
RAC1GeneProductENSG00000136238 (Ensembl)
RRM2GeneProductENSG00000171848 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TNFSS10GeneProductENSG00000117560 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
UCHL1GeneProductENSG00000154277 (Ensembl)
VAV2GeneProductENSG00000160293 (Ensembl)
VEGFAGeneProductENSG00000112715 (Ensembl)
WNT signalingPathwayWP428 (WikiPathways)

Annotated Interactions

No annotated interactions

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