Wnt/beta-catenin signaling in leukemia (Homo sapiens)
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Description
The Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-Catenin activation by the Axin/APC/CK1/GSK3B protein complex. This pathway is based on figure 5 from Misaghian et al.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
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Ontology Terms
Bibliography
- Misaghian N, Ligresti G, Steelman LS, Bertrand FE, Bäsecke J, Libra M, Nicoletti F, Stivala F, Milella M, Tafuri A, Cervello M, Martelli AM, McCubrey JA; ''Targeting the leukemic stem cell: the Holy Grail of leukemia therapy.''; Leukemia, 2009 PubMed Europe PMC Scholia
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Annotated Interactions
No annotated interactions