Humoral immune response to fungal and bacterial pathogens (Drosophila melanogaster)

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1Dap Type PPGFungal and Bacterial Virulence FactorsLysine type PPGProteolytic cascadeFungal B-1-3-glucansPlasmatocyteFat Body CellThiolester ProteinsHemolymphJakSPETab2Myd88Tak1spzFaddDomelessimdkeyGNBP1ird5pshRelpllPGRP-SDDiap2TlGNBP3PGRP-SAPGRP-LCimdDiptericinDreddJNK Signalingtubupd3PPStatStatStatStatStatNucleusDifDorsalcactDifDorsalcactPDifDorsalRelPRelDrosomycinAntimicrobial proteins


Description

Pathways regulating Drosophila's humoral response to bacterial and fungal pathogens. Pathogens such as fungal B-1-3-glucans and virulence factors illicit signalling pathways through receptors on body fat cells of Drosophila Melanogaster (Protein Toll, PGRP-LC, and Domeless). The activation of receptors initiates pathways that increase transcription of antimicrobial agents and thioester proteins. This pathway is based on figure 1 from Igboin et al.

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Ontology Terms

 

Bibliography

  1. Igboin CO, Griffen AL, Leys EJ; ''The Drosophila melanogaster host model.''; J Oral Microbiol, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116924view09:44, 16 May 2021EweitzModified title
90080view05:03, 13 October 2016Khanspersoverhaul
90079view23:52, 12 October 2016KhanspersModified title
88668view15:31, 12 August 2016JmeliusOntology Term : 'immune response pathway' added !
88667view15:31, 12 August 2016JmeliusOntology Term : 'PW:0000004' removed !
88666view15:31, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
85929view18:26, 21 June 2016AAR&CoModified description
85823view19:22, 15 June 2016AAR&CoModified description
85822view18:57, 15 June 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Diap2GeneProductFBgn0015247 (Ensembl)
DifGeneProductFBgn0011274 (Ensembl)
DiptericinProteinP24492 (Uniprot-TrEMBL)
DomelessGeneProductFBgn0043903 (Ensembl)
DorsalProteinC7LA93 (Uniprot-TrEMBL) Dorsal Not Specified
DreddGeneProductFBgn0020381 (Ensembl)
DrosomycinProteinP41964 (Uniprot-TrEMBL)
FaddGeneProductFBgn0038928 (Ensembl)
GNBP1GeneProductFBgn0040323 (Ensembl)
GNBP3GeneProductFBgn0040321 (Ensembl)
JNK SignalingPathway
JakGeneProductFBgn0004864 (Ensembl)
Myd88GeneProductFBgn0033402 (Ensembl)
PGRP-LCGeneProductFBgn0035976 (Ensembl)
PGRP-SAGeneProductFBgn0030310 (Ensembl)
PGRP-SDGeneProductFBgn0035806 (Ensembl)
RelGeneProductFBgn0014018 (Ensembl)
SPEGeneProductFBgn0039102 (Ensembl)
StatGeneProductFBgn0016917 (Ensembl)
Tab2GeneProductFBgn0086358 (Ensembl)
Tak1GeneProductFBgn0026323 (Ensembl)
TlGeneProductFBgn0262473 (Ensembl)
cactGeneProductFBgn0000250 (Ensembl)
imdGeneProductFBgn0013983 (Ensembl)
ird5GeneProductFBgn0024222 (Ensembl)
keyGeneProductFBgn0041205 (Ensembl)
pllGeneProductFBgn0010441 (Ensembl)
pshGeneProductFBgn0030926 (Ensembl)
spzGeneProductFBgn0003495 (Ensembl)
tubGeneProductFBgn0003882 (Ensembl)
upd3GeneProductFBgn0053542 (Ensembl)

Annotated Interactions

No annotated interactions

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