IL-1 signaling pathway (Mus musculus)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none InhibitionCY -> NUAcetylationPalmitoylationControlDesumoylationGolgi apparatusCY->EXReceptorDeacetylationActivationCY -> NURecruitmentLigandDSumoylationEnzyme complexProteins in a complex interactionDCY->EXDemethylationAutophosphorylationPhosphorylationMTUbiquitinationCytoplasmMolecular associationDENExtracellularDProteolytic cleavageDNucleusReaction through unknown mechanisms/molecules(Protein-protein interaction)DMolecule in the pathwayPMEndosomeAccession Number: NetPath 13ECPM -> CYCY -> NUGlycosylationNUPlasma membraneGODeubiquitinationMitochondriaTranslocationDephosphorylationMethylationPM -> CYDCYIl1rapSirpaPELI1Irak1Irak2MAPK1Irak4MAP3K14NFKBIAMAP2K1Irak1CHUKMAP3K7RELAIl1bIl1aTraf6Il1r1SirpaIl1rnIRAK3Il1aMAPK3CAPN1MAPK1IRAK4Irak1MAP3K7IP2NFKBIAPLCG1Il1r1Traf6MAP3K14PRKCZMAP3K7IP1MAP3K7IP1Il1aCHUKMAP3K7IP2NFKB1Traf6MAP3K7IP2MAP3K7MAP3K7MAP3K7IP2CAPNS1Irak1Irak1NFKBIBMAP3K7MAP3K7IP2Il1r1Gene SymbolIl1r2Il1r2PTPN11MAPK8Traf6CASP1SQSTM1IKBKAPIl1r2PTPN11RELAIl1bMAP3K7IP1Il1rapIl1rnMAP3K7IP2TOLLIPTraf6AKT1TOLLIPMAP3K7Myd88PELI1Traf6Irak1MAP3K7IRAK4Il1bIl1bIl1aName: IL-1 signaling pathwayOrganism: Mus musculus


Description

The interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor, IL1R2. Upon binding to the ligands, interleukin-1 alpha or beta, IL1R1 interacts with IL-1 receptor accessory protein (IL1RAP) to activate the MAPK/JNK signaling modules. The MAPK pathway leads to activation of NFkB complex. As both IL-1 and TNF alpha stimulate the MAPK signaling module and activate NFkB, they are synergistic and complement each other's activity. Source: [NetPath](http://www.netpath.org/pathways?path_id=NetPath_13)

Comments

GenMAPP notes 
NetPath 13: IL-1 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

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Quality Tags

Image:Unconnected.pngFix interactions
Image:NeedsRef.pngAdd references
Image:Curated.pngApproved version
Image:MissingXref.pngAnnotate nodes

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
138122
Approved
view06:54, 16 March 2025EgonwTwo translocations
138121view06:47, 16 March 2025EgonwModified description
117902view10:28, 23 May 2021EweitzModified title
97052view15:15, 26 April 2018Olivier.traetsLine changes
69141view18:16, 8 July 2013MaintBotUpdated to 2013 gpml schema
67365view10:42, 26 June 2013Christine ChichesterOntology Term : 'interleukin-1 signaling pathway' added !
41331view00:25, 2 March 2011MaintBotRemoved redundant pathway information and comments
35778view06:16, 13 February 2010MaintBotAdded description
20755view11:29, 14 November 2008MaintBot[[Pathway:Mus musculus:IL-1 NetPath 13]] moved to [[Pathway:WP37]]: Moved to stable identifier
8160view13:46, 7 January 2008MaintBot[[Pathway:Mouse:IL-1 NetPath 13]] moved to [[Pathway:Mus musculus:IL-1 NetPath 13]]: Renaming species
7700view16:10, 18 December 2007MaintBotfixed category names
7239view12:41, 4 November 2007MaintBotAdded categories to GPML
6458view22:19, 22 May 2007A.Pandeygpml file for [[Mouse:IL-1_NetPath_13]]

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProduct11651 (Entrez Gene)
CAPN1GeneProduct12333 (Entrez Gene)
CAPNS1GeneProduct12336 (Entrez Gene)
CASP1GeneProduct12362 (Entrez Gene)
CHUKGeneProduct12675 (Entrez Gene)
Gene SymbolGeneProduct
IKBKAPGeneProduct230233 (Entrez Gene)
IRAK3GeneProduct73914 (Entrez Gene)
IRAK4GeneProduct266632 (Entrez Gene)
Il1aGeneProduct16175 (Entrez Gene)
Il1aGeneProductENSMUSG00000027399 (Ensembl)
Il1bGeneProduct16176 (Entrez Gene)
Il1bGeneProductENSMUSG00000027398 (Ensembl)
Il1r1GeneProduct16177 (Entrez Gene)
Il1r2GeneProduct16178 (Entrez Gene)
Il1rapGeneProduct16180 (Entrez Gene)
Il1rnGeneProduct16181 (Entrez Gene)
Irak1GeneProduct16179 (Entrez Gene)
Irak2GeneProduct108960 (Entrez Gene)
Irak4GeneProduct266632 (Entrez Gene)
MAP2K1GeneProduct26395 (Entrez Gene)
MAP3K14GeneProduct53859 (Entrez Gene)
MAP3K7GeneProduct26409 (Entrez Gene)
MAP3K7IP1GeneProduct66513 (Entrez Gene)
MAP3K7IP2GeneProduct68652 (Entrez Gene)
MAPK1GeneProduct26413 (Entrez Gene)
MAPK3GeneProduct26417 (Entrez Gene)
MAPK8GeneProduct26419 (Entrez Gene)
Myd88GeneProduct17874 (Entrez Gene)
NFKB1GeneProduct18033 (Entrez Gene)
NFKBIAGeneProduct18035 (Entrez Gene)
NFKBIBGeneProduct18036 (Entrez Gene)
PELI1GeneProduct67245 (Entrez Gene)
PLCG1GeneProduct18803 (Entrez Gene)
PRKCZGeneProduct18762 (Entrez Gene)
PTPN11GeneProduct19247 (Entrez Gene)
RELAGeneProduct19697 (Entrez Gene)
SQSTM1GeneProduct18412 (Entrez Gene)
SirpaGeneProduct19261 (Entrez Gene)
TOLLIPGeneProduct54473 (Entrez Gene)
Traf6GeneProduct22034 (Entrez Gene)

Annotated Interactions

No annotated interactions
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