Meiotic recombination genes (Saccharomyces cerevisiae)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Early Exchange GenesEarly Synapsis GenesLate Exchange GenesEarly Exchange GenesDouble Strand BreakSynapsis Genespathway convergences**RAD50SPO11MEI4MER2REC102REC104REC114XRS2MRE11HOP1RED1MEK1RAD52RAD57RAD55RAD51RAD50RAD51RAD52RAD57HOP1RED1Name: Meiotic recombination genesOrganism: Saccharomyces cerevisiae


Description

Meiotic double strand breaks are initiated by Spo11, a conserved topoisomerase-derived protein, together with its partner subunits. After the breaks are formed, Spo11 remains covalently attached to the 5 prime strands at both ends of the DNA. It is released through an endonucleolytic cleavage reaction, which is facilitated by MRX (Mre11, Rad50, and Xrs2) and Sae2. This reaction liberates Spo11, which is attached to a short oligonucleotide. The 5 prime strands are further processed by exonucleases, such as Exo1 in yeast, leading to the production of long single-stranded tails. These tails are coated with RPA, an ssDNA-binding protein, before being replaced by recombinases Rad51 and Dmc1. The recombinases form a nucleoprotein filament and search for sequence similarity, which is primarily located on the homologous chromosome. This process leads to the production of D-loop structures.

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Quality Tags

Image:Unconnected.pngFix interactions
Image:NeedsRef.pngAdd references
Image:Curated.pngApproved version

Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
125517
Approved
view03:01, 24 February 2023AlexanderPicoModified description
125512view02:07, 24 February 2023AlexanderPicoadded description
117286view10:57, 20 May 2021EweitzModified title
87533view02:04, 25 July 2016AlexanderPicoOntology Term : 'cell cycle pathway, meiotic' added !
87532view02:03, 25 July 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
69605view20:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
41837view04:50, 2 March 2011MaintBotRemoved redundant pathway information and comments
21471view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Genes of Meiotic Recombination]] moved to [[Pathway:WP377]]: Moved to stable identifier
20392view19:56, 3 November 2008AlexanderPico
8723view14:07, 7 January 2008MaintBotAdded to category $category
8721view14:07, 7 January 2008MaintBotUploaded new pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
HOP1GeneProductS000001334 (SGD)
MEI4GeneProductS000001954 (SGD)
MEK1GeneProductS000005878 (SGD)
MER2GeneProductS000003782 (SGD)
MRE11GeneProductS000004837 (SGD)
RAD50GeneProductS000005194 (SGD)
RAD51GeneProductS000000897 (SGD)
RAD52GeneProductS000004494 (SGD)
RAD55GeneProductS000002483 (SGD)
RAD57GeneProductS000002411 (SGD)
REC102GeneProductS000004321 (SGD)
REC104GeneProductS000001200 (SGD)
REC114GeneProductS000004740 (SGD)
RED1GeneProductS000004253 (SGD)
SPO11GeneProductS000001014 (SGD)
XRS2GeneProductS000002777 (SGD)

Annotated Interactions

No annotated interactions

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