Apoptosis modulation by HSP70 (Homo sapiens)
From WikiPathways
Description
This pathway summarizes the various ways by which HSP70 proteins can inhibit apoptosis. This pathway was originally adapted from rat.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
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- Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY; ''Role of Hsp70 in regulation of stress-kinase JNK: implications in apoptosis and aging.''; FEBS Lett, 1998 PubMed Europe PMC Scholia
- Orsini F, Migliaccio E, Moroni M, Contursi C, Raker VA, Piccini D, Martin-Padura I, Pelliccia G, Trinei M, Bono M, Puri C, Tacchetti C, Ferrini M, Mannucci R, Nicoletti I, Lanfrancone L, Giorgio M, Pelicci PG; ''The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.''; J Biol Chem, 2004 PubMed Europe PMC Scholia
- Schett G, Steiner CW, Gröger M, Winkler S, Graninger W, Smolen J, Xu Q, Steiner G; ''Activation of Fas inhibits heat-induced activation of HSF1 and up-regulation of hsp70.''; FASEB J, 1999 PubMed Europe PMC Scholia
- Jäättelä M, Wissing D, Kokholm K, Kallunki T, Egeblad M; ''Hsp70 exerts its anti-apoptotic function downstream of caspase-3-like proteases.''; EMBO J, 1998 PubMed Europe PMC Scholia
- Garrido C, Schmitt E, Candé C, Vahsen N, Parcellier A, Kroemer G; ''HSP27 and HSP70: potentially oncogenic apoptosis inhibitors.''; Cell Cycle, 2003 PubMed Europe PMC Scholia
- Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES; ''Negative regulation of the Apaf-1 apoptosome by Hsp70.''; Nat Cell Biol, 2000 PubMed Europe PMC Scholia
- Mosser DD, Caron AW, Bourget L, Meriin AB, Sherman MY, Morimoto RI, Massie B; ''The chaperone function of hsp70 is required for protection against stress-induced apoptosis.''; Mol Cell Biol, 2000 PubMed Europe PMC Scholia
- Gurbuxani S, Schmitt E, Cande C, Parcellier A, Hammann A, Daugas E, Kouranti I, Spahr C, Pance A, Kroemer G, Garrido C; ''Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.''; Oncogene, 2003 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
APAF1 | GeneProduct | 317 (Entrez Gene) | |
Apoptosis | Pathway | WP254 (WikiPathways) | |
BID | GeneProduct | 637 (Entrez Gene) | |
CASP2 | GeneProduct | 835 (Entrez Gene) | |
CASP3 | GeneProduct | 836 (Entrez Gene) | |
CASP6 | GeneProduct | 839 (Entrez Gene) | |
CASP7 | GeneProduct | 840 (Entrez Gene) | |
CASP8 | GeneProduct | 841 (Entrez Gene) | |
CASP9 | GeneProduct | 842 (Entrez Gene) | |
CYCS | GeneProduct | 54205 (Entrez Gene) | |
FADD | GeneProduct | 8772 (Entrez Gene) | |
FAS-Ligand | GeneProduct | ENSG00000117560 (Ensembl) | |
FAS | GeneProduct | 355 (Entrez Gene) | |
HSPA1A | GeneProduct | 3303 (Entrez Gene) | |
MAP3K1 | GeneProduct | 4214 (Entrez Gene) | |
MAPK10 | GeneProduct | 5602 (Entrez Gene) | |
NF-kB Pathway | Pathway | ||
NFKB1 | GeneProduct | 4790 (Entrez Gene) | |
PDCD8 | GeneProduct | 9131 (Entrez Gene) | Apoptosis Inducing Factor |
RIPK1 | GeneProduct | 8737 (Entrez Gene) | |
TNF | GeneProduct | ENSG00000204490 (Ensembl) | |
TNFRSF1A | GeneProduct | 7132 (Entrez Gene) |
Annotated Interactions
No annotated interactions