Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Skeletal muscle cellGSK3BPI3K4EPBEIF2B2N-WASPPGC1FoxOAMPKActin polymerization& myofibrillogenesisMyostatinAKT1Integrin B1NEBMAFbxLC3TNFrecMURF1IRS1PLD1TNFrecILKPDK1MTORProtein synthesisS6KAMPKPTENIGF1recTNFJNKIGF1Amino acidIGFBP5ActRIIBNFKB1mTORC2 complexMLST8MAPKAP1RICTORMTORmTORC1 complexMLST8AKT1S1RPTORDEPTORMTORSMAD3SMAD2TWEAKTNFProtein degradationProtein synthesisName: Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signalingOrganism: Homo sapiens


Description

The signaling pathway that involves insulin-like growth factor 1 (IGF1), and a variety of other components that affect the pathway, plays an important role in the regulation of skeletal muscle growth. The kinase Akt, or protein kinase B (PKB), is a central component in the pathway and is involved in both muscle synthesis, through mammalian target of rapmycin (mTOR) and glycogen synthase kinase 3B (GSK3B), and muscle degradation, through the transcription factors of the FoxO family. The pathway also involves several feedback loops such as the negative feedback of S6K, phosphorylated by mTORC1, which inhibits IRS, or the positive feedback of mTORC2, which is necessary to maximize the activation of Akt. A variety of other factors and pathways also influence the IGF1-Akt signaling pathway at various points. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3850)

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access
Image:MissingXref.pngAnnotate nodes

Ontology Terms

 

Bibliography

  1. Schiaffino S, Mammucari C; ''Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models.''; Skelet Muscle, 2011 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137217
Approved
view08:58, 1 March 2025EgonwModified description
135064view12:56, 2 August 2024EweitzRefine cell type label position
135063view12:55, 2 August 2024EweitzFix identifier, standardize case
135062view12:54, 2 August 2024EweitzEconomize layout
135061view12:51, 2 August 2024EweitzEconomize layout
121711view04:51, 26 February 2022EweitzRefine graphics
121710view04:51, 26 February 2022EweitzUse gene symbol
110688view13:38, 28 May 2020Fehrhartaddec complex nodes and IDs
110686view13:30, 28 May 2020Fehrhartreplaced mTORC1 and 2 complex labels with complexes
106412view21:57, 28 August 2019KhanspersModified description
105592view04:46, 10 August 2019KhanspersModified description
88165view08:32, 29 July 2016Mkutmonunconnected line
87350view20:50, 21 July 2016AlexanderPicoOntology Term : 'cell of skeletal muscle' added !
87349view20:50, 21 July 2016AlexanderPicoOntology Term : 'CL:0000188' removed !
87125view18:40, 18 July 2016AlexanderPicoOntology Term : 'cell of skeletal muscle' added !
87124view18:40, 18 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87123view18:39, 18 July 2016AlexanderPicoOntology Term : 'insulin-like growth factor signaling pathway' added !
87121view18:39, 18 July 2016AlexanderPicoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
4EPBGeneProductENSG00000151247 (Ensembl) EIF4E
AKT1GeneProductENSG00000142208 (Ensembl)
AKT1S1GeneProductENSG00000204673 (Ensembl)
AMPKGeneProductENSG00000111725 (Ensembl)
ActRIIBGeneProductENSG00000114739 (Ensembl)
Actin polymerization & myofibrillogenesisPathway
Amino acid MetaboliteCHEBI:33709 (ChEBI)
DEPTORGeneProductENSG00000155792 (Ensembl)
EIF2B2GeneProductENSG00000119718 (Ensembl)
FoxO GeneProductfamily of transcription factors
GSK3BGeneProductENSG00000082701 (Ensembl)
IGF1GeneProductENSG00000017427 (Ensembl)
IGF1rec GeneProductENSG00000140443 (Ensembl)
IGFBP5GeneProductENSG00000115461 (Ensembl) most important of grup of IGF binding proteins that inhibit binding of IGF1 to its receptor
ILKGeneProductENSG00000166333 (Ensembl)
IRS1GeneProductENSG00000169047 (Ensembl) not sure, because also 2, 3, 4
Integrin B1GeneProductENSG00000150093 (Ensembl)
JNKProteinA0A087WVY6 (Uniprot-TrEMBL)
LC3GeneProductENSG00000101460 (Ensembl)
MAFbxGeneProductENSG00000156804 (Ensembl) FBXO32/atrogin-1
MAPKAP1GeneProductENSG00000119487 (Ensembl)
MLST8GeneProductENSG00000167965 (Ensembl)
MTORGeneProductENSG00000198793 (Ensembl)
  • effect of AKT on MTOR is indirect
  • Part of two multiprotein complexes, TORC 1 and TORC 2
MURF1 GeneProductENSG00000158022 (Ensembl) TRIM63
MyostatinGeneProductENSG00000138379 (Ensembl)
N-WASPGeneProductENSG00000106299 (Ensembl)
NEBGeneProductENSG00000183091 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
PDK1GeneProductENSG00000152256 (Ensembl)
PGC1 GeneProductENSG00000109819 (Ensembl)
PI3KGeneProductENSG00000105851 (Ensembl) phosphatidlinositol 3-kinase
PLD1GeneProductENSG00000075651 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
Protein degradation Pathway
Protein synthesisPathway
RICTORGeneProductENSG00000164327 (Ensembl)
RPTORGeneProductENSG00000141564 (Ensembl)
S6KGeneProductENSG00000108443 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
TNFGeneProductENSG00000228978 (EcoGene)
TNFGeneProductENSG00000228978 (Ensembl)
TNFrecGeneProductENSG00000067182 (Ensembl)
TWEAKGeneProductENSG00000125657 (Ensembl)
mTORC1 complexComplexCPX-503 (Complex Portal)
mTORC2 complexComplexCPX-4402 (Complex Portal)

Annotated Interactions

No annotated interactions

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