ERK pathway in Huntington's disease (Homo sapiens)

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1Signal transducersTranscription factorsLigandsReceptorsApoptotic moleculesDownstreamkinasesDownstream targetsMAPK1CREBCASP3GlutamateRAF1CASP7ELK1GRM1BDNFEGFRNTRK2RASHTTMSK1EGFMAP2K1MAP2K2MAPK3


Description

This ERK pathway is implicated in Huntington's disease. The ligands BDNF, EGF, and Glu bind to their respective receptors (TrkB, EGFR, mGluR) and start a signal transduction pathway starting with RAS and RAF1, which leads to the stimulation of MEK then ERK. ERK promotes function of MSK1 (a downstream kinase), ElK1 and CREB (transcription factors), and caspases 3/7 (apoptotic molecules). These downstream targets are implicated in producing the effects of Huntington's disease at the cellular level. This pathway is based on Figure 1 from Bodai et al. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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Ontology Terms

 

Bibliography

  1. Bodai L, Marsh JL; ''A novel target for Huntington's disease: ERK at the crossroads of signaling. The ERK signaling pathway is implicated in Huntington's disease and its upregulation ameliorates pathology.''; Bioessays, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
129064view02:18, 10 March 2024EweitzModified description
128359view21:17, 2 February 2024Ash iyerFixed interation of HTT
128350view07:02, 2 February 2024KhanspersAdded xrefs, updated HTT, added interaction from HTT to ERK
120593view20:48, 17 December 2021EweitzUse gene symbols
120592view20:42, 17 December 2021EweitzTighten graphics, fix case
117714view12:28, 22 May 2021EweitzModified title
108057view09:40, 27 November 2019NirupamaWe added the disease-causing mutation in HTT that inhibits BDNF and EGF, and activates Glutamate.
106752view13:23, 17 September 2019MaintBotHMDB identifier normalization
106395view21:29, 28 August 2019KhanspersModified description
105575view06:30, 9 August 2019KhanspersModified description
97672view11:12, 1 June 2018AMTanOntology Term : 'Huntington's disease' added !
89748view23:55, 29 September 2016KhanspersModified title
89643view23:38, 22 September 2016Khanspersupdated xrefs
88611view23:04, 11 August 2016AAR&CoOntology Term : 'Huntington disease pathway' added !
88596view19:45, 11 August 2016Mkutmonfix unconnected lines
87413view11:30, 22 July 2016MkutmonOntology Term : 'disease pathway' added !
87412view11:30, 22 July 2016MkutmonOntology Term : 'signaling pathway' added !
87203view13:50, 19 July 2016AAR&CoModified description
87202view13:43, 19 July 2016AAR&CoModified title
87201view13:43, 19 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BDNFGeneProductENSG00000176697 (Ensembl)
CASP3GeneProductENSG00000164305 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
GRM1GeneProductENSG00000152822 (Ensembl)
GlutamateMetaboliteHMDB0000148 (HMDB)
HTTGeneProductENSG00000197386 (Ensembl) mutant Huntingtin
MAP2K1GeneProductMAP2K1 (HGNC)
MAP2K2GeneProductMAP2K2 (HGNC)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductMAPK3 (HGNC)
MSK1GeneProductENSG00000100784 (Ensembl)
NTRK2GeneProductENSG00000148053 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RASGeneProductENSG00000174775 (Ensembl)

Annotated Interactions

No annotated interactions

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