TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition (Homo sapiens)

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ArcPathVisio Brace Ellipse EndoplasmicReticulum GolgiApparatus HexagonPathVisio MimDegradation Mitochondria Octagon PentagonPathVisio Rectangle RoundedRectangle SarcoplasmicReticulum TriangleEquilateralEast TrianglePathVisio none Thyroid cellNucleusEpithelial MarkersCDH16E-CADMesenchymal MarkersN-CADTNCFN1CDH6VIMLate Response TFEMT Transcription FactorsRUNX2ID1SNAI1SNAI2Early Response TFSMAD PathwaysPPPTGF-BPSMAD3SMAD4PSMAD2PMAPK3PMAPK1PAKT2PAKT1PAKT3Non-SMAD PathwayMAPKPI3KName: TGF-beta signaling in thyroid cells for epithelial-mesenchymal transitionOrganism: Homo sapiens


Description

This pathway is based on the Figure 7 of "Cadherin 6 Is a New RUNX2 Target in TGF-β Signalling Pathway" (see bibliography). TGF-B is a target gene in thyroid cells in the causation of cancer. When TGF-B is activated, the pathway can take 2 directions, through a SMAD pathway or a Non-Smad pathway. Through the SMAD pathway, SMAD separates into SMAD2/3, SMAD4, and involves phosphates into the nuclear signalling. Through the Non-SMAD pathway, the activation of MAPK and Pi3k causes the activation of ERK, AKT and phosphates, and then into the nuclear signalling. Within the nuclear signalling, EMT-TF has two responses, early and late. With the early response, EMT-TF signals to Id1 and RUNX2, and with the late response, EMT-TF signals to Snai1 and Snai2. Depending on the response also dictates the type of marker that will follow. If early, N-CAD,FN1,VIM,TNC, and CDH6 all cause the activation of the Mesenchymal markers. If late, E-CAD, and CDH16 cause the inhibition of the Epithelial Markers. Proteins on this pathway have targeted assays available via the [CPTAC Assay Portal](https://assays.cancer.gov/available_assays?wp_id=WP3859).

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Quality Tags

Image:Curated.pngApproved version
Image:PLoS_OpenAccess.pngOpen Access
Image:Wplogo_31.pngCommunity: CPTAC

Ontology Terms

No Tags!
 

Bibliography

  1. Sancisi V, Gandolfi G, Ragazzi M, Nicoli D, Tamagnini I, Piana S, Ciarrocchi A; ''Cadherin 6 is a new RUNX2 target in TGF-β signalling pathway.''; PLoS One, 2013 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
137179
Approved
view08:25, 28 February 2025EgonwMade a pathway clickable
137137view23:13, 27 February 2025KhanspersModified description
128360
CPTAC
view21:32, 2 February 2024Ash iyerAdded protein complex oject and added pathway identifier for SMAD pathway
128349view06:46, 2 February 2024Khanspersspecified gene product node xrefs, layout, clarification
117840view15:13, 22 May 2021EweitzModified title
117837view15:11, 22 May 2021EweitzModified title
106478view19:42, 3 September 2019KhanspersModified description
105460view05:09, 8 August 2019KhanspersModified description
90120view00:17, 14 October 2016Khanspersupdated layout and interactions
89942view13:56, 6 October 2016EgonwModified description
88619view02:02, 12 August 2016AAR&CoAdded Data Nodes
88618view02:01, 12 August 2016AAR&CoPeriodical save, work in progress
87420view11:32, 22 July 2016MkutmonOntology Term : 'signaling pathway' added !
87310view21:17, 20 July 2016AAR&CoModified description
87306view20:51, 20 July 2016AAR&CoOntology Term : 'thyroid cancer' added !
87305view20:48, 20 July 2016AAR&CoNew pathway

External references

DataNodes

View all...
Name  ↓Type  ↓Database reference  ↓Comment  ↓
AKT1GeneProductENSG00000142208 (Ensembl) AKT Not Specified
AKT2GeneProductAKT2 (HGNC)
AKT3GeneProductAKT3 (HGNC)
CDH16GeneProductENSG00000166589 (Ensembl)
CDH6GeneProductENSG00000113361 (Ensembl)
E-CADGeneProductP12830 (Uniprot-TrEMBL)
FN1GeneProductENSG00000115414 (Ensembl)
ID1GeneProductENSG00000125968 (Ensembl)
MAPK1GeneProductMAPK1 (HGNC)
MAPK3GeneProductMAPK3 (HGNC) ERK Not Specified
N-CADProteinA0A024RC42 (Uniprot-TrEMBL)
RUNX2GeneProductENSG00000124813 (Ensembl)
SMAD PathwaysPathwayWP3859 (WikiPathways)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
TGF-BGeneProductP01137 (Uniprot-TrEMBL)
TNCGeneProductENSG00000041982 (Ensembl)
VIMGeneProductENSG00000026025 (Ensembl)

Annotated Interactions

No annotated interactions

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