T-cell antigen receptor (TCR) pathway during Staphylococcus aureus infection (Homo sapiens)

From WikiPathways

AAR&Co, Kristina Hanspers, Martina Kutmon, Chris Evelo, Egon Willighagen, et al.

Description

This pathway is based on Figure 4 of "A Model of an Integrated Immune System Pathway in Homo sapiens and Its Interaction with Superantigen Producing Expression Regulatory Pathway in Staphylococcus aureus: Comparing Behavior of Pathogen Perturbed and Unperturbed Pathway"(see bibliography). The pathway displays the T-cell receptors of homo sapiens when infected with the disease Staphylococcus Enterotoxin B. The binding of a superantigen to the T cell receptor results in a protein signaling pathway resulting in cell proliferation, differentiation, and immune response due to altered DNA expression. SEB refers to Staphylococcal Enterotoxin B.

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Ontology Terms

Pathway Ontology : infectious disease pathway immune response pathway

Disease : toxic shock syndrome

Cell Type : T cell

Bibliography

Tomar N, De RK; ''A model of an integrated immune system pathway in Homo sapiens and its interaction with superantigen producing expression regulatory pathway in Staphylococcus aureus: comparing behavior of pathogen perturbed and unperturbed pathway.''; PLoS One, 2013 PubMed Europe PMC Scholia

History

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Revision	Action	Time	User	Comment
127932	view	23:07, 17 January 2024	Khanspers	improved layout
121717	view	15:08, 26 February 2022	Eweitz	Fix IDs, use gene symbols
121707	view	04:41, 26 February 2022	Eweitz	Use gene symbol
120420	view	13:10, 30 November 2021	Eweitz	Fix incorrectly-cased symbols, and update some others to Ensembl preferred label
116778	view	09:50, 14 May 2021	Eweitz	Modified title
116777	view	09:49, 14 May 2021	Eweitz	Modified title
106753	view	13:23, 17 September 2019	MaintBot	HMDB identifier normalization
97627	view	10:08, 31 May 2018	AMTan	Ontology Term : 'T cell' added !
90702	view	11:53, 13 December 2016	Evelo	Modified title
90701	view	11:53, 13 December 2016	Evelo	Modified title
90029	view	19:38, 8 October 2016	AlexanderPico	Modified description
89739	view	23:37, 29 September 2016	Khanspers	Modified title
89738	view	23:36, 29 September 2016	Khanspers	Modified description
89737	view	23:35, 29 September 2016	Khanspers	corrected label
89641	view	23:03, 22 September 2016	Khanspers	minor layout
89607	view	09:09, 20 September 2016	Egonw	Reverted a premature change I made. Clearly human now.
88763	view	19:06, 14 August 2016	AAR&Co	Modified description
88762	view	18:59, 14 August 2016	AAR&Co	Added Data Nodes
88759	view	18:51, 14 August 2016	AAR&Co	Edited Annotations
88758	view	18:47, 14 August 2016	AAR&Co	Modified Datanodes
88752	view	18:38, 14 August 2016	AAR&Co	Periodical save, work in progress
88747	view	18:28, 14 August 2016	AAR&Co	Periodical save, work in progress
88742	view	18:18, 14 August 2016	AAR&Co	Periodical save, work in progress
88549	view	01:34, 11 August 2016	AAR&Co	Periodical save, work in progress
88537	view	00:54, 11 August 2016	AAR&Co	Periodical save, work in progress
88533	view	00:44, 11 August 2016	AAR&Co	Periodical save, work in progress
88529	view	00:24, 11 August 2016	AAR&Co	Periodical save, work in progress
88523	view	00:07, 11 August 2016	AAR&Co	Modified Datanodes
88508	view	23:18, 10 August 2016	AAR&Co	Periodical save, work in progress
88503	view	23:00, 10 August 2016	AAR&Co	Modified Datanode
88498	view	22:57, 10 August 2016	AAR&Co	Periodical save, work in progress
88496	view	22:53, 10 August 2016	AAR&Co	Modified Datanodes
88489	view	22:33, 10 August 2016	AAR&Co	Periodical save, work in progress
88483	view	22:23, 10 August 2016	AAR&Co	Periodical save, work in progress
88480	view	22:12, 10 August 2016	AAR&Co	Periodical save, work in progress
88193	view	23:42, 30 July 2016	AAR&Co	Modified Datanode
88192	view	23:40, 30 July 2016	AAR&Co	Modified Datanode Gene ID
88189	view	23:34, 30 July 2016	AAR&Co	Modified Database
88174	view	14:34, 29 July 2016	Mkutmon	Ontology Term : 'infectious disease pathway' added !
88167	view	08:41, 29 July 2016	Mkutmon	unconnected lines
87424	view	11:33, 22 July 2016	Mkutmon	Ontology Term : 'immune response pathway' added !
87344	view	17:39, 21 July 2016	AAR&Co	Modified title
87343	view	17:39, 21 July 2016	AAR&Co	Added Datanodes
87342	view	17:27, 21 July 2016	AAR&Co	Modified description
87341	view	17:26, 21 July 2016	AAR&Co	Ontology Term : 'toxic shock syndrome' added !
87340	view	17:22, 21 July 2016	AAR&Co	Added Datanodes
87339	view	17:21, 21 July 2016	AAR&Co	Periodical save, work in progress
87338	view	17:14, 21 July 2016	AAR&Co	Added Data Nodes
87337	view	17:10, 21 July 2016	AAR&Co	Periodical save, work in progress
87336	view	17:05, 21 July 2016	AAR&Co	Added Datanodes

External references

DataNodes

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Name	Type	Database reference	Comment
AHSA1	GeneProduct	ENSG00000100591 (Ensembl)
AKT	GeneProduct	ENSG00000142208 (Ensembl)
AP1	GeneProduct	ENSG00000177606 (Ensembl)
BCL10	GeneProduct	ENSG00000142867 (Ensembl)
CARMA1	GeneProduct	ENSG00000198286 (Ensembl)
CBL	GeneProduct	ENSG00000110395 (Ensembl)
CD28	GeneProduct	ENSG00000178562 (Ensembl)
CD3D	GeneProduct	ENSG00000167286 (Ensembl)	CD3 Not Specified
CD40L	GeneProduct	ENSG00000102245 (Ensembl)
CD4	GeneProduct	ENSG00000010610 (Ensembl)
CD8A	GeneProduct	ENSG00000153563 (Ensembl)	CD8 Not Specified
CDK4	GeneProduct	ENSG00000135446 (Ensembl)
CHP1	GeneProduct	ENSG00000187446 (Ensembl)
CHUK	GeneProduct	ENSG00000213341 (Ensembl)
COT	GeneProduct	ENSG00000107968 (Ensembl)
CSF2	GeneProduct	ENSG00000164400 (Ensembl)
CTLA4	GeneProduct	ENSG00000163599 (Ensembl)
Calcium	Metabolite	HMDB0000464 (HMDB)
Calmodulin	Protein	ENSG00000198668 (Ensembl)
Calmodulin	Protein	P62204 (Uniprot-TrEMBL)
DAG1	GeneProduct	ENSG00000173402 (Ensembl)	Dag Not Specified
DLGH1	GeneProduct	ENSG00000075711 (Ensembl)
ERK	GeneProduct	ENSG00000102882 (Ensembl)
FOS	GeneProduct	ENSG00000170345 (Ensembl)
FYN	GeneProduct	ENSG00000010810 (Ensembl)
GADS	GeneProduct	ENSG00000100351 (Ensembl)
GRB2	GeneProduct	ENSG00000177885 (Ensembl)
GRP1	GeneProduct	O08967 (Uniprot-TrEMBL)
GSK3B	GeneProduct	ENSG00000082701 (Ensembl)
ICOS	GeneProduct	ENSG00000163600 (Ensembl)
IFNG	GeneProduct	ENSG00000111537 (Ensembl)
IKBKB	GeneProduct	ENSG00000104365 (Ensembl)
IKBKG	GeneProduct	ENSG00000269335 (Ensembl)
IL10	GeneProduct	ENSG00000136634 (Ensembl)
IL2	GeneProduct	ENSG00000109471 (Ensembl)
IL4	GeneProduct	ENSG00000113520 (Ensembl)
IL5	GeneProduct	ENSG00000113525 (Ensembl)
IP3	Metabolite	439456 (PubChem-compound)
ITK	GeneProduct	ENSG00000113263 (Ensembl)
JNK2	GeneProduct	ENSG00000050748 (Ensembl)
JUN	GeneProduct	ENSG00000177606 (Ensembl)
LAT	GeneProduct	ENSG00000213658 (Ensembl)
LCK	GeneProduct	ENSG00000182866 (Ensembl)
MALT1	GeneProduct	ENSG00000172175 (Ensembl)
MEK1	GeneProduct	ENSG00000169032 (Ensembl)
MEK2	GeneProduct	ENSG00000126934 (Ensembl)
MKK7	GeneProduct	ENSG00000076984 (Ensembl)
NCK	GeneProduct	ENSG00000158092 (Ensembl)
NFAT	GeneProduct	ENSG00000101096 (Ensembl)	General Name for Transcription Factors
NFKB1	GeneProduct	ENSG00000109320 (Ensembl)
NFKBIA	GeneProduct	ENSG00000100906 (Ensembl)	Ikb Not Specified
NIK	GeneProduct	ENSG00000006062 (Ensembl)
PAK	GeneProduct	ENSG00000149269 (Ensembl)
PD1	GeneProduct	ENSG00000188389 (Ensembl)
PDK1	GeneProduct	ENSG00000152256 (Ensembl)
PI3K	GeneProduct	ENSG00000121879 (Ensembl)
PIP3	Metabolite	HMDB0010147 (HMDB)
PLCG1	GeneProduct	ENSG00000124181 (Ensembl)
PRKCQ	GeneProduct	ENSG00000065675 (Ensembl)
PTPRC	GeneProduct	ENSG00000081237 (Ensembl)
RAF	GeneProduct	ENSG00000132155 (Ensembl)
RAS	GeneProduct	ENSG00000126458 (Ensembl)
SHP1	GeneProduct	ENSG00000111679 (Ensembl)
SLP76	GeneProduct	ENSG00000043462 (Ensembl)
SOS	GeneProduct	ENSG00000115904 (Ensembl)
TAK1	GeneProduct	ENSG00000135341 (Ensembl)
TNF	GeneProduct	ENSG00000232810 (Ensembl)
TRAJ10	GeneProduct	ENSG00000211879 (Ensembl)
TRBJ1-4	GeneProduct	ENSG00000281958 (Ensembl)
ZAP70	GeneProduct	ENSG00000115085 (Ensembl)