RIOK1 and RIOK2 in EGFR- and PI3K-mediated tumorigenesis (Homo sapiens)
From WikiPathways
Description
This pathway is based on figure 7 from Read et al. When over-expressed the RIOK1 and RIOK2 proteins signal downstream of Akt to induce tumorigensis. RIOK2 also regulates signaling upstream of AKT through stimulation of the mTORC2 complex (indicated by red interactions). In the absence of RIOK1 and RIOK2 (indicated by blue interactions) the p53-dependent ribosomal stress checkpoint via RPL1 is induced.
Quality Tags
Ontology Terms
Bibliography
- Read RD, Fenton TR, Gomez GG, Wykosky J, Vandenberg SR, Babic I, Iwanami A, Yang H, Cavenee WK, Mischel PS, Furnari FB, Thomas JB; ''A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma.''; PLoS Genet, 2013 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
AKT1 | GeneProduct | AKT1 (HGNC) | AKT Not Specified |
AKT2 | GeneProduct | AKT2 (HGNC) | AKT Not Specified |
AKT3 | GeneProduct | AKT3 (HGNC) | AKT Not Specified |
Apoptosis | Pathway | WP31 (WikiPathways) | |
Cell Cycle Arrest | Pathway | WP31 (WikiPathways) | |
EGFR | GeneProduct | ENSG00000146648 (Ensembl) | |
FOXO3 | GeneProduct | FOXO3 (HGNC) | |
MAPKAP1 | GeneProduct | MAPKAP1 (HGNC) | |
MLST8 | GeneProduct | MLST8 (HGNC) | |
MTOR | GeneProduct | MTOR (HGNC) | |
PIK3CA | GeneProduct | PIK3CA (HGNC) | |
PTEN | GeneProduct | PTEN (HGNC) | |
RICTOR | GeneProduct | RICTOR (HGNC) | |
RIOK1 | GeneProduct | RIOK1 (HGNC) | |
RIOK2 | GeneProduct | RIOK2 (HGNC) | |
RPL11 | GeneProduct | RPL11 (HGNC) | |
TP53 | GeneProduct | TP53 (HGNC) |
Annotated Interactions
No annotated interactions